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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 9, Issue: June
Article Id: JPRS-MB-0000831
Title: Impact of am fungi on growth and biochemical content of pea during salt stress
Category: Microbiology
Section: Research Article
Country: India
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The present study was carried out to evaluate the impact of AM fungi on some physiological and biochemical parameters of Pea plant (Pisum sativum L.).To study the impact AM fungi on salt tolerance an experiment was conducted. The plants were exposed to the increasing concentration of NaCl salt: 50 mM, 75 mM and 100 mM NaCl. The salt stress treatment was started after one month at the interval of five days. For each treatment, five replicates were maintained. Results showed that AMF-inoculated plants had shown better resistance to salt stress than non-inoculated plants. Salinity stress had caused a significant decrease in the fresh and dry weight of root, shoot and number of leaves. Also, the amount of chlorophyll a, chlorophyll b and total chlorophylls has decreased significantly. However, biosynthesis of proline in leaves has activated. The results showed that salinity stress reduced the growth and chlorophyll amount but an increase in proline was noted in the leaf and seed of pea. The AM fungi used for pot culture were Acaulospora gerdemannii, Glomus fasciculatum, Glomus intraradices and Scutellospora heterogama.

Cite this article as: Shinde B. P. and Jaya Thakur,Impact of am fungi on growth and biochemical content of pea during salt stress,Journal of Pharmacy Research 2015,9(6),402-407

Journal: Journal of Pharmacy Research , Volume: 9, Issue: June
Article Id: JPRS-PC-0000800
Title: 3D QSAR Studies on Substituted Arylaminopyrimidine Derivatives as Anaplastic Lymphoma Kinase (ALK) Inhibitors
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Background: Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a promising new target for therapy of certain cancers. Methods: In the present study, 3D QSAR analyses on 45 ALK inhibitors were performed by comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods to rationalize the structural requirements responsible for the inhibitory activity of these compounds. The alignment strategy was used for these compounds by means of Distill function defined in SYBYL X 1.2. Results and Discussion: The best CoMFA and CoMSIA models obtained for the 32 training set molecules were statistically significant with q2 of 0.700 and 0.681, cross-validated coefficient (r2cv) of 0.680 and 0.601, and conventional coefficients (r2) of 0.998 and 0.988, respectively. Both the models were validated by an external test set of 13 compounds giving satisfactory prediction (r2pred) of 0.873 and 0.891for CoMFA and CoMSIA models, respectively. Conclusion: The CoMFA and CoMSIA models developed in this study would provide useful information for the design of novel inhibitors with better ALK inhibitory activity.

Cite this article as: Palak K. Parikh, Manjunath Ghate, Kinjal Patel,3D QSAR Studies on Substituted Arylaminopyrimidine Derivatives as Anaplastic Lymphoma Kinase (ALK) Inhibitors,Journal of Pharmacy Research 2015,9(6),383-395.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: June
Article Id: JPRS-PB-0000799
Title: Cyclin-Dependent Kinases as valid targets for cancer treatment.
Category: Pharmaceutical Biotechnology
Section: Review Article
Country: India
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Ineffectiveness of conventional chemotherapeutic drugs and appearance of several side effects such as hair loss and anemia, nausea, vomiting, diarrhea, infections, fatigue and destruction of the immune system, due to inability to discriminate normal cells and cancerous cells, have led to development of new anti proliferative drugs with less side effect and more efficacy .Cell cycle and cell regulation play significant role in drug discovery as they provide new opportunities for discovery of new drug target for treatment of cancers. CDKs are introduced as significant target for anticancer drugs as they are directly and indirectly involved in cell cycle events such as progression, transcription and DNA repair, so development of Cdk inhibitors become goal of many drug discovery companies and researchers, for treatment of cancers. In this paper we focused on Cdks , their regulatory role in cell cycle and their prominent characteristics as valid target for drug discovery . Finally, we have reviewed 14 upcoming anticancer candidates whose target is CDKs .These anticancer drugs are such as Flavopiridol, Roscovitine, Dinaciclib, SNS032, AT7519, PD0332991, RGB-286638, P276-00, BAY-1000394, TG02/SG1317, EM-1421. PHA-848125. LEE-011 and LY2835219 which are currently under investigation for treatment of cancer. We hope this paper gives informative background for understanding importance of Cdks as effective targets for cancer therapy with high effective results and minimum side effect .

Cite this article as: Mahin Ghorbani , Hamed Karimi,Cyclin-Dependent Kinases as valid targets for cancer treatment,Journal of Pharmacy Research 2015,9(6),377-382

Journal: Journal of Pharmacy Research , Volume: 9, Issue: June
Article Id: JPRS-PB-0000798
Title: Study of Physiochemical Parameters for Optimizing Tyrosinase Activity in Rhodococcus ruber C4 and Pseudomonas geniculata C7/C10
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Background: Tyrosinase is an enzyme of industrial potential. Methods: The production of tyrosinase on the “tyro” media was estimated under variable physiochemical parameters for Rhodococcus ruber C4 (RR4), Pseudomonas geniculata C7 (PG7) and Pseudomonas geniculata C10 (PG10). Results and Discussion: The study highlighted that the pH 7 shown the optimum activity of tyrosinase in all three cultures. The temperature set at 30?C further enhanced the tyrosinase activity with 72 hours of incubation and having starch as a carbon source in all three cultures investigated. Conclusion: The Tyro Media and conditions were optimized for maximum tyrosinase activity using the given cultures.

Cite this article as: Sapna S. Ingle, Chandrahas N. Khobragade, Study of Physiochemical Parameters for Optimizing Tyrosinase Activity in Rhodococcus ruber C4 and Pseudomonas geniculata C7/C10,Journal of Pharmacy Research 2015,9(6),372-376

Journal: Journal of Pharmacy Research , Volume: 9, Issue: June
Article Id: JPRS-MB-0000797
Title: Evidence of pathogenic mechanism that cause diabetes and therapeutic implications
Category: Microbiology
Section: Research Article
Country: India
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Backgound: The aim of this paper is to review the cellular process that potentially link diabetes. Diabetes Mellitus is a metabolic disorder characterized by hyperglycemia due to defect in insulin secretion, insulin action or both. Methods: The major cause of death and illness is due to the complications caused by increased glucose concentrations. All the accessible antidiabetic drugs are associated with side effects. Results: The combination therapy could be a novel and highly effective healing strategy to manage hyperglycemia. Combination of viable drugs with phytochemicals may reduce the side effects caused by these synthetic drugs. Conclusion: Herbal products have been thought to be inherently safe, because of their natural origin and traditional use rather than based on systemic studies.

Cite this article as: Rajeswari Anburaj,Evidence of pathogenic mechanism that cause diabetes and therapeutic implications,Journal of Pharmacy Research 2015,9(6),365-371

Journal: Journal of Pharmacy Research , Volume: 9, Issue: June
Article Id: JPRS-BGSA-0000795
Title: Mycobacterium Kansasii Hypothetical Proteins Capable of Coding Enzymes
Category: Bioinformatics (Genome & Sequence Analysis )
Section: Research Article
Country: India
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Background: Mycobacterium kansasii known as Nontuberculous mycobacterium is genetically linked to M.tuberculosis. The genome of M. kansasii highlighted several genes coding hypothetical proteins and these were investigated further for functionality. Methods: The results brought up by CDD BLAST, INTERPROSCAN, PFAM and CATH domain search programs facilitated to search inherent enzyme functions based on available conserved domains in several hypothetical proteins. Results and Discussion: M. kansasii showcased 128 probable enzyme coding hypothetical proteins based on conserved domains analysis. Conclusion: Some M. kansasii hypothetical proteins codes for enzymes and possibly may function in cellular metabolism as investigated by insilico approach.

Cite this article as: Rajni Mishra, Dilip Gore and Avinash Upadhyay,Mycobacterium Kansasii Hypothetical Proteins Capable of Coding Enzymes,Journal of Pharmacy Research 2015,9(6),359-364

Journal: Journal of Pharmacy Research , Volume: 9, Issue: June
Article Id: JPRS-PC-0000794
Title: In vivo neuroprotection study of two 1,2,4-triazole derivatives in Drosophila melanogaster Oregon K flies
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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This study presents the neuroprotective effect of two 1,2,4-triazole derivatives namely,     4-amino-3-(4-hydroxybenzyl)-1H-1,2,4-triazole-5(4H)-thione (C1) and 4-amino-3-(3- methoxybenzyl)-1H-1,2,4-triazole-5(4H)-thione (C2) assayed in vivo using Drosophila melanogaster (oregon K strain) as a model for neuroprotection studies. Oxidative stress was induced by paraquat, a neuro toxin. The antioxidant efficacy of the molecules was evaluated through the determination of malondialdehyde (MDA), glutathione (GSH), antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT) in the homogenate of the flies. The induced oxidative stress by paraquat exposure was evidenced by significant increase in the level of MDA and declining in the level of GSH. In case of C1 and C2 pretreated flies, a significant diminish in the level of MDA, re-establishment of GSH level and modulatory effect on antioxidant enzymes were seen. The compound C1 exhibited better level of protective ability against the stress compared to C2.

Cite this article as: Balladka Kunhanna Sarojini, Padmanabha Savithri Manjula, Channa Govindaraju Darshan Raj ,In vivo neuroprotection study of two 1,2,4-triazole derivatives in Drosophila melanogaster Oregon K flies,Journal of Pharmacy Research 2015,9(6),351-358

Journal: Journal of Pharmacy Research , Volume: 9, Issue: June
Article Id: JPRS-BGSA-0000793
Title: Shigella boydii database: A Functional Genomic Approach
Category: Bioinformatics (Genome & Sequence Analysis )
Section: Research Article
Country: India
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Background: Shigella boydii as a pathogen is important to study with respect to its virulence control. The genome sequence analysis helps us in understanding the mode of action of the organism. Methodology: In our study, a detail analysis of the previously sequenced S. boydii available at NCBI database were linked with the genomic as well as proteomic datasets to create a single access point database using Microsoft Access, which could be retrieved from www.saibioinfosys.in or even by emailing. Result and Conclusion: Study created the detailed database of the S. boydii which could be downloaded completely with detailed datasets.

 

Cite this article as:Priyanka Patel, Dilip Gore, Jitendra Shivhare, Ankita Thapak,Shigella boydii database: A Functional Genomic Approach,Journal of Pharmacy Research 2015,9(6),348-350.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: June
Article Id: JPRS-P'Col-0000792
Title: Antioxidant activity of methanolic root extract of Gynochthodes ridsdalei Razafim. & B.Bremer (Rubiaceae), an endemic, endangered medicinal plant of Southern Western Ghats, India
Category: Pharmacology
Section: Research Article
Country: India
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Antioxidant activity of methanolic root extract of Gynochthodes ridsdalei ( Syn: Morinda reticulata) was studied for its free radical scavenging property on different in vitro models such as Reducing power, DPPH, nitric oxide radical scavenging, hydroxyl radical scavenging and superoxide radical scavenging assays. The extract showed good free radical scavenging ability in all in vitro models except in superoxide scavenging assays, which showed only 43.3% in 1000µg/ml. IC 50 values were found to be 0.12, 0.43, 0.33 mg/l in DPPH, Nitric oxide, superoxide respectively.

 

Cite this article as: Renji R.Nair and A.Gangaprasad,Antioxidant activity of methanolic root extract of Gynochthodes ridsdalei Razafim. & B.Bremer (Rubiaceae), an endemic, endangered medicinal plant of Southern Western Ghats, India,Journal of Pharmacy Research 2015,9(6),343-347