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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 9, Issue: July
Article Id: JPRS-PB-00001027
Title: Rapid Micropropagation of Lepidium sativum L. - A Medicinal Herb for Folklore Remedies
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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An efficient protocol has been developed for regeneration of Lepidium sativumplantlets using shoot tip, cotyledonary leaf and internodes as explants. Proliferation of shoots was achieved on MS medium supplemented with various concentrations of IAA with BAP alone or kinetin MS medium with BAP (5.0mg/l + IAA (2.0mg/l) was optimum for inducing the maximum number of shoots from shoot tip (6.55) followed by cotyledonary leaves (4.45) and internode (0.60). Hundred percent callusing was achieved on MS medium supplemented with 2, 4-D (1.0, 1.5&2.0 mg/l) along with kinetin (1.0mg/l& 0.5mg/l), respectively.MS medium having 2, 4-D (1.0 mg/l and 1.5 mg/l in combination with BAP (1.0mg/l &1.5mg/l), respectively also showed 100% callusing for shoot tip and cotyledonary leaves. The best rooting media were with [IAA(2.0 mg/l) + BAP (5.0 mg/l&2.0 mg/l),) and IAA (2.0 mg/land 3.0 mg/l + kinetin (0.5 mg/l)]. Rooted plantlets were transferred to thermocol cups filled with a mixture of soil and sand (3:1). The rooted seedlings were acclimatized to soil conditions with 80% survival rate.

Cite this article as:Pragya Bhasin, Dinesh Bansal, Anita Grewal, Anita R. Sehrawat,Rapid Micropropagation of Lepidium sativum L. - A Medicinal Herb for Folklore Remedies, Journal of Pharmacy Research 2015,9(7),480-483

Journal: Journal of Pharmacy Research , Volume: 9, Issue: July
Article Id: JPRS-MB-00001046
Title: Antifungal and Phytochemical Analysis of Lantana Camara, Citrus Limonum (Lemon), Azadirachta Indica (Neem) and Hibiscus Rosasinensis (China Rose)
Category: Microbiology
Section: Research Article
Country: India
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Lemon, Neem, Lantana Camara and China rose have been important herbs in the ayurvedic and indigenous therapeutic system. The present study was designed to investigate the preliminary phytochemical analysis and evaluation of antifungal activities of the ethanolic, methanolic and aqueous extracts of these four plants against the two fungal organisms.To evaluate their application as antifungal agents, leaves of the selected plants were used for preparing three types of extracts such as aqueous extract, ethanolic and methanolic extracts and evaluated for their in-vitro anti fungal activity against trichophyton rubrum and candida albicans. The extracts were also subjected to preliminary phytochemical analysis. The ethanolic extracts showed high antifungal activity against the test organisms compared to methanolic extracts. Aqueous extracts showed minimal antifungal activity against the test fungal pathogens. Preliminary phytochemical analysis revealed the presence of tannins, alkaloids, terpenoids, cardiac glycosides, saponins, phlobatanins and flavonoids. Results obtained in this study reveals that alkaloids, flavonoids, terpenoids, glycosides and tannins are present with high intensity in ethanolic and methanolic extract.The present study suggests that appropriate bioactive compounds may be extracted from leaves of these selected plants and used as an alternate to antibiotics.

Cite this article as : Leena Das and Suchitra Godbole,Antifungal and Phytochemical Analysis of Lantana Camara, Citrus Limonum (Lemon), Azadirachta Indica (Neem) and Hibiscus Rosasinensis (China Rose),Journal of Pharmacy Research 2015,9(7),476-479

Journal: Journal of Pharmacy Research , Volume: 9, Issue: July
Article Id: JPRS-MDR-0000998
Title: Antimicrobial protein of the marine bacterium Pseudoalteromonas sp. and its proteolytic property
Category: Marine Drug Related study
Section: Research Article
Country: India
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Background: Marine bacteria of the genus Pseudoalteromonas are recognized as major producers of various biologically active metabolites of relevant clinical interest, some of which include halogenated compounds, cyclic peptides, toxic proteins, enzymes or exopolymer polyanionic substances, among others. Furthermore, the extracellular proteins of Pseudoalteromonas have been reported to contain both hydrolytic and antibiotic activities. In previous studies, we isolated a protein with a molecular mass of 80 kDa from Pseudoalteromonas sp., with showed antimicrobial activity against S. aureus MRSA, E. coli and multiresistant P. aeruginosa. In this context, it became important elucidate the mechanisms of action by which antimicrobial compounds affect certain molecular targets to inhibit bacterial growth or to cause death. In this work, we studied whether the antimicrobial protein of Pseudoalteromonas sp. is linked to hydrolytic activity when tested on a strain of methicillin-resistant Staphylococcus aureus. Methods: The antimicrobial protein was purified by molecular exclusion and ion exchange chromatography and its antimicrobial activity was tested by the disk diffusion method. Caseinolytic activity was measured by the method of Kunitz in the presence or absence of inhibitors. We observed that the protein lost activity in the presence of serine protease inhibitors. However, the presence or absence of inhibitors did not affect its antimicrobial activity. Conclusion: The antimicrobial activity of this protein from Pseudoalteromonas sp. showed proteolytic activity. However, this activity was not responsible for its antimicrobial activity.

Jorge Bautista Secun, Alejandra Hernández Santoyo, Víctor Monteón Padilla, Ruth López Alcántara ,Antimicrobial protein of the marine bacterium Pseudoalteromonas sp. and its proteolytic property,Journal of Pharmacy Research 2015,9(7),457-462

Journal: Journal of Pharmacy Research , Volume: 9, Issue: July
Article Id: JPRS-P'Col-00001026
Title: Pharmacological Activities of Bridelia retusa: A Review
Category: Pharmacology
Section: Review Article
Country: India
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Bridelia retusa is commonly known as Asana in Marathi. It has long been used in Indian folk medicine to treat broad spectrum of diseases, such as liver diseases, for removal of urinary concretion ,inflammatory diseases etc. Phytochemical studies on Bridelia retusa disclosed major chemical constituents including steroids, triterpenoids, tannins and flavonoids. A research report on Bridelia retusa reveals for its analgesic activity, anti-inflammatory activity, hepatoprotective activity, antimicrobial activity, immunomodulatory activity and hypoglycemic effect. Hence in this article, we discuss the biochemical constituents, traditional uses and therapeutic potentials of Bridelia retusa.

Ghawate V. B,Jadhav V. S, and Bhambar R. S.,Pharmacological Activities of Bridelia retusa: A Review,Journal of Pharmacy Research 2015,9(7),415-418

Journal: Journal of Pharmacy Research , Volume: 9, Issue: July
Article Id: JPRS-P'Col-00001001
Title: Evaluation of Cardioprotective Role of Vinpocetine in Isoproterenol-induced Myocardial Infarction in Rats
Category: Pharmacology
Section: Research Article
Country: India
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Purpose: Vinpocetine is a phosphodiesterase type-1 inhibitor having strong vasodilating effect through cAMP and cGMP elevation. Vasodilators may play positive role in myocardial infarction (MI). As vinpocetine has not been explored for its cardioprotective role so far, we proposed to investigate the same in experimental model. Wistar albino rats were randomly divided into control, isoproterenol (85 mg/kg, s.c. on 6th & 7th day), vinpocetine (10 mg/kg/day, p.o.), milrinone (4 mg/kg/day, p.o.), vinpocetine + isoproterenol and milrinone + isoproterenol groups. On 8th day lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), total antioxidant capacity (TAC) in serum and reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS), Na+/K+ ATPase (NKA) in myocardium were estimated. Results: Isoproterenol-induced MI manifested a significant (P < 0.001) increase in the LDH, CK-MB, NKA, TBARS and a substantial decrease in GSH & TAC levels (P < 0.001 & P < 0.05, respectively). These levels were significantly reverted towards normal on treatment with vinpocetine and milrinone. Per se groups of these drugs however, did not show any significant changes when compared with the control. Histopathological evaluation also revealed the same trend. Conclusion:Biochemical and histopathological parameters clearly indicate the cardioprotective potential of vinpocetine due to its antioxidative and myocardial membrane stabilizing effects.

Cite this article as: Mohammed Kaleem and Syed Ehtaishamul Haque,Evaluation of Cardioprotective Role of Vinpocetine in Isoproterenol-induced Myocardial Infarction in Rats, Journal of Pharmacy Research 2015,9(7),408-414

Journal: Journal of Pharmacy Research , Volume: 9, Issue: July
Article Id: JPRS-PB-0000999
Title: Chrysoeriol a bioactive flavonoid, in Cardiospermum halicacabum L. leaves and their free radical scavenging activities
Category: Pharmaceutical Biotechnology
Section: Research Article
Country: India
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Objective: The aim of the present study was to evaluate the free radical scavenging activity of the compound Chrysoeriol (CS).Methods: Free radical scavenging was determined by using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2’-azinobis 3 ethylbenzthiazoline-6-sulphonic acid (ABTS), ferric reducing antioxidant power (FRAP), nitric oxide scavenging assay (NO), reducing power, hydroxyl, superoxide radical scavenging and hydrogen peroxide radical assay, metal chelating activity, phosphomolybdneum, ferric thiocyanate (FTC) and also peroxynitrite scavenging assay.Results: Free radical scavenging potentiality of DPPH (37.62 µg/ml), ABTS (35.31 µg/ml), FRAP (34.79 µg/ml), NO (36.28 µg/ml), reducing power (40.09 µg/ml), hydroxyl (36.56 µg/ml), superoxide (40.48 µg/ml), and hydrogen peroxide (38.02 µg/ml), metal chelating (35.96 µg/ml), phosphomolybdneum (36.90 µg/ml), FTC (34.96 µg/ml), and also peroxynitrite (37.49 µg/ml) for the CS and compared to standard drug BHT (32.74 µg/ml) respectively.Conclusion: The present investigation clearly indicated that the CS possesses antioxidant properties and serve as free radical inhibitors or scavengers, acting possibly as primary antioxidants.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: July
Article Id: JPRS-P'Col-00001006
Title: Hepatoprotective and antioxidant effect of Hesperidin against Isoniazid, Rifampicin and Pyrazinamide induced hepatotoxicity in rats.
Category: Pharmacology
Section: Research Article
Country: India
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Background: Drug induced hepatotoxicity is found to be one of the foremost reason for Liver injury. Pharmacological intervention preferably using natural bioactive compounds to prevent hepatotoxicity is the need of the hour. So a study was designed to investigate the protective effect of naturally occurring flavonoid Hesperidin on Isoniazid (H), Rifampicin(R) and Pyrazinamide (Z) induced hepatotoxicity and oxidative stress. Materials and Methods:Rats were divided into four different groups (n=6), control, HRZ, HRZ plus Hesperidin , standard group HRZ plus silymarin p.o for 50 days and after rats were sacrificed blood and liver were collected and used for biochemical and histological studies. RESULTS: Hepatotoxicity induced by HRZ was evidenced by a significant increase in liver marker enzyme such as alanine transaminase(ALT) ,aspartate transaminase (AST), alkaline phosphatase (ALP) , Gamma glutamyl transferase (gGT), Lactate dehydrogenase (LDH), lipid peroxidative products such as Lipid hydroperoxides (LHP), conjugated dienes(CD), malondialdehyde (MDA) as well as decreased the level of antioxidant enzymes superoxide dismutase(SOD),catalase(CAT), glutathione reductase(GR), reduced glutathione(GSH), glutathione S transferase(GST), glutathione peroxidase(Gpx), vitamin C and E(VIT E& C) in experimental rats. These changes were not observed in the group where Hesperidin was administered along with HRZ. The effect of Hesperidin was compared with a standard drug, silymarin. The changes in biochemical parameters were supported by histopathological evidence. CONCLUTION:  It is to be concluded that the Hesperidin can be used as a protective agent against antitubercular drug induced oxidative liver injury and necrosis.