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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 

Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 CiteScore 2016: 0.93(Top level : Life Science)

Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
2016 0.926 Cites / Doc. (4 years) 2016 0.926
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
2016   Cites / Doc. (4 years) 2016 0.926
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
External Cites per document 2016 0.926
Cites per document 2014 0.607
Cites per document 2015 0.789
Cites per document 2016 0.926

Manuscripts Published

Journal: Journal of Pharmacy Research , Volume: 9, Issue: August
Article Id: JPRS-P'Col-00001071
Title: Evaluation of Anxiolytic Activity in four selected species of Arisaema
Category: Pharmacology
Section: Research Article
Country: India
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Background: Arisaema is a large genus containing numerous species which are being used traditionally by the various tribes and communities for treatment of various ailments such as asthma bronchitis, cold, cough, laryngitis, ringworm, sores, boils, abscesses, as analgesic, antitumor, and pesticide agents. Arisaema cumbile for treating dementia and neurological symptoms. Arisaema flavum for tetanus, epilepsy, skin diseases and as insecticide. So taking into account traditional uses of genus, four species A. tortuosum, A. jacquemontii, A. concinuum and A. flavum are selected for evaluating antianxiety potential in species. Method: In the present investigation hydroalcoholic extracts of tubers are prepared. All the crude extracts are evaluated for antianxiety activity in mice using elevated plus maze and Y maze model of anxiety. Result and Discussion: Among all the extract A.concinuum and A. flavum exhibited significant antianxiety activity with respect to control as well as standard (diazepam 2mg/kg) while other extracts have also increased the time spent in open arms.Conclusion: From this study it can be concluded that arisaema species were found useful in treating or decreasing anxiety in animal models.

 

Cite this article as:Hemlata Verma, VK Lal and KK Pant,Evaluation of Anxiolytic Activity in four selected species of Arisaema, Journal of Pharmacy Research 2015,9(8),569-572.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: August
Article Id: JPRS-PA-00001074
Title: Development and validation of spectrophotometric and HPLC methods For the determination of Famotidine in bulk drug formulations.
Category: Pharmaceutical Analysis
Section: Research Article
Country: India
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Two simple, rapid and selective methods were developed for the determination of Famotidine in drug substance and its pharmaceutical preparations. The first method (I) is based on UV Spectroscopy.UV spectra of Famotidine are recorded. The absorption maxima (lmax) were observed at 286nm. Beer’s law was obeyed over the concentration range from 2 to 20 µg/ml and it shows linearity The validation of the proposed method was further confirmed by Recovery studies at 50%, 100% and 150%. The percentage recovery values from 96.83%w/w, 102.7%w/w, 97.70%w/w, 99.07%w/w. This serves as a good index of accuracy and reproducibility of the study. The second method is based on the Reverse phase HPLC method was developed by using Methanol: Acetonitrile in the ratio of 50:50 as a mobile phase and Hypersil C18 (5 micron, 250 4.6 mm) column as a stationary phase. Flow rate was 1.5 ml/min. The uv detector was operated at 286nm. The method was validated for specificity, linearity, precision, accuracy and limit of quantification. The recovery studies showed that the observed percentage recovery of Famotidine was found to be 98.4 to 98.9 %. The retention time of Famotidine was found to be 5.907min. The developed method was accurate and precise which was evident from the analytical data and recovery studies.

Cite this article as:M.V. Kumudhavalli, S.Alexandar, and B. Jaykar,Development and validation of spectrophotometric and HPLC methods For the determination of Famotidine in bulk drug formulations,Journal of Pharmacy Research 2015,9(8),562-568

Journal: Journal of Pharmacy Research , Volume: 9, Issue: August
Article Id: JPRS-PCS-00001066
Title: Solubility enhancement of nevirapine by cocrystallisation technique
Category: Pharmaceutics
Section: Research Article
Country: India
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The objective of present study was to enhance solubility of Nevirapine by cocrystallisation technique.Nevirapine is non-nucleoside reverse transcriptase inhibitor (NNRTI) class of antiretroviral and having poor aqueous solubility and dissolution profile. The method used for co-crystal formation was neat grinding method. The co-crystals were prepared by using conformer Maleic acid. The method used for co-crystal formation was neat grinding method. Further prepared co-crystals were characterized by Powder X-ray diffractometry (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transformation Infra-red Spectroscopy (FTIR). Moreover they were studied for melting point determination, flow property studies and dissolution studies. All the performed study revealed formation of co-crystals, improvement in micromeritic properties and dissolution behavior of drug. The result shows that solubility of Nevirapine was improved by 106 folds via crystal engineering technique.

Cite this article as: Yogesh K. Nalte, Vilas A. Arsul, Santosh G. Shep, DR. Sunil B. Bothara,Solubility enhancement of nevirapine by cocrystallisation technique,Journal of Pharmacy Research 2015,9(8),556-561

Journal: Journal of Pharmacy Research , Volume: 9, Issue: August
Article Id: JPRS-PC-00001103
Title: Stereo Selective Total Synthesis of Phomonol
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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A new stereo selective method has been described for the total synthesis of phomonol from optically active L-(-) diisopropyl tartarate (L-(-) DIPT). The sequence of synthesis includes Swern oxidation, Mac-Millan, Grignard and Oxa-Michael addition reactions as key steps in achieving the target molecule.

 

Cite this article as: Bhaskar. K , Paramesh Jangili and A. Jaya Shree, Stereo Selective Total Synthesis of Phomonol,Journal of Pharmacy Research 2015,9(8),550-555.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: August
Article Id: JPRS-BMB-0000905
Title: Marker assisted sex differentiation in dioecious plants
Category: Biochemistry and Molecular Biology
Section: Review Article
Country: India
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Dioecy in general is associated with sexual dimorphism. But, dioecious plants account for only 6% of flowering species and it is difficult to diagnose sex of the plant before flowering. Early sex identification in plants is of great importance to breeders. Biochemical and cytological analyses do not always support sex determination in plants. Thus, the focus is on identifying molecular markers for gender differentiation. In this article, different plant species are listed for which sex-linked molecular markers have been developed and various molecular tools used to study the sex-linked markers have been reviewed. It also summarizes the data available on the most popular marker systems used in the research.

Cite this article as: Anita Grewal and Shalini Goyat,Marker assisted sex differentiation in dioecious plants,Journal of Pharmacy Research 2015,9(8),531-549

Journal: Journal of Pharmacy Research , Volume: 9, Issue: August
Article Id: JPRS-PCS-00001065
Title: Altered Pharmacokinetics and Pharmacodynamics of Glimepiride by the concomitant use of Quercetin in diabetic rats: PK/PD modeling
Category: Pharmaceutics
Section: Research Article
Country: India
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The effect of quercetin on the pharmacokinetics (PK) and pharmacodynamics (PD) of glimepiride was studied in normal and streptozotocin induced diabetic rats. In normal and diabetic rats the combination of glimepiride with quercetin increased significantly (p < 0.01) all the pharmacokinetic parameters, such as Cmax, AUC0- n, AUCtotal, t½, MRT and decreased the clearance, Vd markedly as compared with the control. In pharmacodynamic studies, the increase in hypoglycemic action by concomitant administration of glimepiride with quercetin was more in diabetic rats than when the drugs were used singly and with the control group, which suggests the enhancement of glucose reduction capacity of glimepiride in diabetic rats along with quercetin. In addition, the combination of glimepiride with quercetin also improved the total antioxidant status in diabetic rats compared with quercetin and glimepiride alone treated groups. In PK/PD modeling of quercetin with glimepiride, the predicted PK and PD parameters are in line with the observed PK and PD parameters. The results revealed that quercetin led to the PK/PD changes have been due to glimepiride increased bioavailability, decreased total clearance and volume of distribution may be due to the inhibition of cytochrome P450 metabolic system. Hence, glimepiride doses may require special attention if administered concomitantly with quercetin or quercetin containing herbal preparations to avoid complications. This could be important in reducing the dose of glimepiride to achieve desired therapeutic effect with minimal adverse effects.

Cite this article as: Sujatha Samala and Ciddi Veeresham,Altered Pharmacokinetics and Pharmacodynamics of Glimepiride by the concomitant use of Quercetin in diabetic rats: PK/PD modeling,Journal of Pharmacy Research 2015,9(8),525-530

Journal: Journal of Pharmacy Research , Volume: 9, Issue: August
Article Id: JPRS-MB-00001064
Title: Prevalence of antimicrobial resistant E. coli in water reservoirs
Category: Microbiology
Section: Research Article
Country: India
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Background: The antibiogram of the E. coli isolated from the different water bodies contaminated by undefined fecal sources have been investigated. Aims and Objectives: To isolate E. coli from water sources and to evaluate their antimicrobial resistance/sensitivity pattern. Results: A total of 296 E. coli strains isolated from pooled samples. Approximately 50% of these isolates expressed resistance to one or more antimicrobials during the study. High degree of resistance was recorded to Ceftazidime followed by Co-trimoxazole, however isolates were also sensitive to Kanamycin and Streptomycin. Conclusion: Isolation of drug resistant E. coli in water reservoirs highlights the importance of water disinfection before its utilization for drinking purpose.

Cite this article as: N. A. Mupidwar , A. B. Ingle and S. P. Magar,Prevalence of antimicrobial resistant E. coli in water reservoirs, Journal of Pharmacy Research 2015,9(8),522-524

Journal: Journal of Pharmacy Research , Volume: 9, Issue: August
Article Id: JPRS-MB-00001063
Title: Prevalence of Multi drug resistance Acinetobacter baumannii in Central India (Nagpur)
Category: Microbiology
Section: Research Article
Country: India
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Background: The study conducted on the patient’s samples highlighted the prevalence of drug resistance A. baumannii when investigated under in vitro conditions. Aims and Objectives: Clinical samples were processed on the selective media: Mac Conkey and Leeds Acinetobacter for the isolation of A. baumannii and further antibiotic sensitivity was tested by Kirby-Baeur antibiotic susceptibility test. Results and Discussion: Study highlighted the prevalence of the multidrug resistance in eighteen strains for >75% (n=24) antibiotics. Conclusion: Prevalence of A. baumannii in clinical samples and their increasing multi drug resistance posing the present threat in front of the society which needs to monitor and especially when the patients are getting hospitalized.

Jimmy B. Vaidya, Vijay N. Charde and Arun B. Ingle,Prevalence of Multi drug resistance Acinetobacter baumannii in Central India (Nagpur),Journal of Pharmacy Research 2015,9(8),517-521

Journal: Journal of Pharmacy Research , Volume: 9, Issue: August
Article Id: JPRS-PC-00001062
Title: In vitro antimicrobial activity of new 2-amino-4-chloropyridine derivatives: A structure-activity relationship study
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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In the present study, a series of new Schiff bases of 2-amino-4-chloropyridine derivatives 3(a-p) were synthesized from the building blocks of 2-amino-4-chloropyridine (1) and different aldehydes (2a-p). Newly synthesized compounds were characterized by different spectral studies. These new compounds were evaluated for their in-vitro antimicrobial effect using the agar-well diffusion method against three Gram positive bacteria (Staphylococcus aureus, Bacillus cereus and Bacillus licheniformis), three Gram negative bacteria (Escherichia coli, Acetobacter sp. and Pseudomonas aeruginosa) and three fungi (Penicillium expansum, Asperigillus flavus and Pichia anomola). The structure-activity relationships of the synthesized compounds were also discussed. Variable and modest activity was observed against the investigated strains of bacteria and fungi. however, the results revealed that, compounds 3b, 3c, 3d, 3f and 3g have exhibited significant biological activity against the tested microorganisms.

Cite this article as: S. Nagashree, C S. Karthik, B L. Sudarshan, L. Mallesha, H P. Spoorthy, K R. Sanjay and P.Mallu,In vitro antimicrobial activity of new 2-amino-4-chloropyridine derivatives: A structure-activity relationship study,Journal of Pharmacy Research 2015,9(8),509-516

Journal: Journal of Pharmacy Research , Volume: 9, Issue: August
Article Id: JPRS-BMB-00001061
Title: HIF1α regulates survival proteins in fish brain under pollutants induced hypoxic condition
Category: Biochemistry and Molecular Biology
Section: Research Article
Country: India
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BACKGROUND: Adequate supply of oxygen is mandatory for the life of aerobic organisms. Failure of oxygen associated with additional anthropomorphic stressors might have a synergistic impact on the aquatic life. Estuarine environment is more prone for hypoxic stress due to diverse environmental factors. Brain ischemia may lead to either adaptive mechanism or apoptotic mechanism. Adaptation to hypoxia induced stress is mediated by specific transcription factor, hypoxia inducible factors a (HIF1α) which serves as the protective guard against the oxidative insult by modulating variety of heat shock proteins (HSPs). TNFα, pro-inflammatory cytokine activated in respond to hypoxia triggers either cell survival / apoptosis through NFκB / MAPK pathway respectively. METHODS: Evaluates the effect of pollution induced hypoxia in the brain of grey mullet by assessing the status of oxidants, antioxidants, HIF1α, HSP70, TNFα and NFκB. RESULTS AND DISCUSSION: There was a significant increase in the level of HNE, expression of HIF1α, HSP70, TNFα and NFkB and decrease in GRR. From the results achieved it is depicted that HIF1α triggers the elevation of HSP70 in response to hypoxia induced stress, which inturn evokes cytoprotective effect by favouring the survival mechanisms via the activation of kinases involved in pro-survival pathway (NFκB) and diminishing TNFα, thereby enabling fish to tolerate and survive in a stressed environment. CONCLUSION: Thus the present study concludes that upregulation of HIF1α play a crucial role by regulating the survival proteins in fish brain under pollutants induced hypoxic condition.

Cite this article as: Padmini, E , Meenakshi, N. and Parimala, P,HIF1α regulates survival proteins in fish brain under pollutants induced hypoxic condition, Journal of Pharmacy Research 2015,9(8),491-499

Journal: Journal of Pharmacy Research , Volume: 9, Issue: August
Article Id: JPRS-P'Col-00001060
Title: Antidiabetic and antidyslipidemic nature of carvacrol, a monoterpenic phenol studied in high-fat -fed and low-dose streptozotocin-induced experimental diabetic rats
Category: Pharmacology
Section: Research Article
Country: India
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Background: Carvacrol, a monoterpenic phenol found to be present in many essential oils of the family Labiatae including Origanum, Satureja, Thymbra, Thymus, and Corydothymus species. It exerts various beneficial and pharmacological properties. The present study was designed to investigate the antidiabetic properties of carvacrol in high fat fed - low dose streptozotocin-induced experimental type 2 diabetes in rats. Methods: Experimental type 2 diabetes was induced with high fat fed diet and low dose streptozotocin. Diabetic rats were treated with Carvacrol (20 mg/Kg b.wt/rat/day) for 30 days. The toxicological parameters such as AST, ALT and ALP were assayed. Biochemical parameters such as fasting blood glucose, glycosylated hemoglobin, insulin, insulin resistance and lipid profile were measured. The levels of glycogen in muscle and liver tissues were determined. Results and discussion: Diabetic rats were treated with Carvacrol (20 mg/Kg b.wt/rat/day) for 30 days. The toxicological parameters such as AST, ALT and ALP as well as biochemical parameters such as fasting blood glucose, glycosylated hemoglobin, insulin, insulin resistance and lipid profile were measured. Oral treatment with carvacrol significantly decreased the elevated levels of fasting glucose, glycosylated hemoglobin, AST, ALT and ALP. The insulin level was improved with an improvement in hepatic and muscle glycogen content of insulin resistant diabetic rats. Carvacrol also normalized the status of lipid profile. These results showed that carvacrol possess significant antihyperglycemic and antihyperlipidemic effects in HFD/STZ-induced type 2 diabetic rats. Conclusion: The results showed that carvacrol exerts potential anti-hyperglycemic and antidyslipidemic effects in HFD/STZ-induced type 2 diabetic rats.

Cite this article as:Umasankar K, Ramya D. R. and Balwin Nambikkairaj,Antidiabetic and antidyslipidemic nature of carvacrol, a monoterpenic phenol studied in high-fat -fed and low-dose streptozotocin-induced experimental diabetic rats,Journal of Pharmacy Research 2015,9(8),484-490

Journal: Journal of Pharmacy Research , Volume: 9, Issue: August
Article Id: JPRS-BMB-00001220
Title: Effects of Osmolytes on The Structural Stability of Bovine Trypsin: A Brief Review
Category: Biochemistry and Molecular Biology
Section: Review Article
Country: India
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Proteases represent a formidable class of industrial enzymes, accounting for about half of the total sale of the enzymes in the world. Trypsin, a protease that has strong specificity, acts as a digestive enzyme and plays a pivotal role in digestive physiology. Proteins have evolved to function within the cellular milieu, where macromolecule and small molecule solutes are present at high concentrations. It has long been known that osmolytes and other solutes transmute protein stability in vitro while certain osmolytes stabilize proteins in vivo to thermal and chemical denaturation arising in stress conditions. The role of various osmolytes and denaturants in the conformational properties and stability of the enzyme, trypsin has been scarcely investigated. In this study an attempt has been made to probe the effects of osmolytes, Glucose, Glycine, Proline, Sucrose, Trehalose and denaturants Guanidine Hydrochloride and Urea along with their concentration effects on the activity and stability of bovine trypsin. Detailed circular dichroism, steady state and temperature dependent fluorescence spectra, UV-Vis spectra and enzyme assay have been studied to scrutinise osmolyte induced stability and denaturant-induced unfolding properties of trypsin. The specific activity peak was found to be highest in sucrose and lowest in urea and GnHCl. The UV-Vis spectroscopic data showed highest absorbance peak for Proline depicting it as the strongest stabilizer, supported by low absorbance peak in fluorescence spectra. On the other hand, Urea was found to be strong denaturant with its lowest absorbance peak and highest intensity peak in UV-Vis and fluorescence spectra respectively. High osmolyte concentration demonstrated an increase in stability in case of Proline and significant rise in denaturing capacity of urea. CD analysis depicted highest positive peak in Proline, concluding it as the strongest stabilizer followed by Sucrose and Trehalose. Alpha helix and beta sheet content was estimated by K2D2 software which supported the trend in stability concordant with the rest of the data.

Cite this article as:Shivani Jain, Sarvesh Seechurn, Parth Gupta, Gaurika Garg,Bhavuk Dhamija, N. Latha, and Kameshwar Sharma YVR,Effects of Osmolytes on The Structural Stability of Bovine Trypsin: A Brief Review, Journal of Pharmacy Research 2015,9(8),500-508.

Journal: Journal of Pharmacy Research , Volume: 9, Issue: August
Article Id: JPRS-PC-00001490
Title: Synthesis of some new 1,2,4-triazoles and 1,3,4-oxadiazoles as a safer anti-inflammatory and analgesic agents
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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A series of 1,2,4-triazole and 1,3,4-oxadiazole derivatives of phenoxyacetic acid were synthesized in order to obtain compounds with promising anti-inflammatory, analgesic activity and lower ulcerogenic potential. All compounds were evaluated for their anti-inflammatory activity by the carrageenan induced rat paw edema test method. The compounds possessing potent anti-inflammatory activity were further tested for their analgesic, ulcerogenic and lipid peroxidation activity. Out of all tested compounds, 3c and 5d showed anti-inflammatory and analgesic activity more than the standard drug ibuprofen. These compounds also showed reduced ulcerogenic potential and lipid peroxidation.