Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . 
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.897 as on date (08.05.2017)
  Scopus Indexed ( link http://www.scimagojr.com/journalsearch.php?q=21100202909&tip=sid&clean=0)
Journal Metrics for this   Drug Invention Today (Source ID: 21100202909): 2014 (SNIP) Source Normalized Impact Per Paper : 0.402; SCImago Journal Rank (SJR):0.301; Impact Per Publication : 0.517 (Top level : Life Science)
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Manuscripts Published

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-D(DD)-0000856
Title: Oral disintegrating tablets: A future compaction
Category: Drug (Discovery/Development)
Section: Review Article
Country: India
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Recent advances in novel drug delivery (NDDS) aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for ease of administration and to achieve better patient compliance. One such approach is oral disintegrating tablets (ODTs). ODTs are solid unit dosage forms, which disintegrates or dissolves rapidly in the mouth without the general requirement for swallowing, the chewing and water. An oral disintegrating tablet provides an advantage particularly for pediatric and geriatric populations and is who have difficulty in swallowing conventional tablets and capsules. This review depicts the various formulation aspects, technologies developed, ingredients used, evaluation tests and marketed formulations.

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-CPS-000062
Title: Energy Dispersive X-Ray Spectroscopy (EDX) Analysis of Ichnocarpus frutescens Plant Parts
Category: Chemistry and Parallel Synthesis
Section: Research Article
Country: India
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Ichnocarpus frutescens (Apocynaceae) commonly known as Thapalaha (Syamolata). Its leaf, stem and root were investigated for its metal mineral content by using Energy Dispersive X-Ray Spectroscopy (EDX). Elemental analysis was performed on eleven elements (C, O, Mg, Al, Si, Cl, K, Ca, Fe, Cu, and Zn). The analysis of EDX showed that root possesses all the tested elements. However, Leaf was found deficient in Fe and Al and stem deficient in Mg.

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-MSNS-000063
Title: Control of phytopathogenic fungi Colletotrichum graminicola using medicinal plant methanolic extracts
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
Country: India
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The antifungal activity of forty nine medicinal plants belonging to different families was tested in vitro on phytopathogenic fungus Colletotrichum graminicola. In which methanolic extracts of forty two plants exhibited varying degrees of inhibition activity against C. graminicola. The results revealed that extract of Terminalia chebula was highly effective in inhibiting the mycelial growth of C. graminicola at 75μg/50μL. The following six plants Acalypha indica, Eichhornia crassipes, Gyanandropsis gyanandra, Suaeda maritime, Tephrosia pumila and Tinospora cordifolia did not exhibit antifungal activity.

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-DFP-000064
Title: [Antibacterial and Antineoplastic Effect of Root of Euphorbia hirta L] ----------- [vol1 issue 1 2009Jan DIT]
Category: Drugs from Plants
Section: Research Article
Country: India
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This dissertation describes the antibacterial and antineoplastic effect (against Ehrlich’s Ascites Carcinoma; EAC) of methanol extract of root of Euphorbia hirta L. Methanol extract showed moderate activity against both Gram positive (Staphylococcus aureus, Bacillus subtilis, and Bacillus megaterium) and Gram negative (Escherchia coli, Shigella dysenteriae and Shigella sonnei) bacteria. In vivo the root extract resulted 45% and 54.4% Ehrlich’s Ascites Carcinoma (EAC) cell growth inhibition at the dose of 10 and 20 mg/kg body weight, respectively. The root extract also showed moderate cytotoxic effect (LC50 37.07 μg.ml-1) against Artemia salina (brine shrimp nauplii) in respect to ampicillin trihydrate (LC50 16.87 μg.ml-1).

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-TPS-000065
Title: In-vitro release, Thermodynamics and Pharmacodynamic Studies of Aceclofenac Transdermal Eudragit Patches
Category: Thermodynamics and Pharmacodynamic Studies
Section: Research Article
Country: India
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Aceclofenac, a nonsteroidal anti-inflammatory drug has been formulated into transdermal Eudragit patches. The drug was first characterized for its physicochemical properties by studying its solubility and its partition coefficient at different pH values. Formulation of Aceclofenac into transdermal patches using three acrylic resin polymers like Eudragit L100, L100-55 and S100 was done. The effect of different plasticizers, like propylene glycol (PG) and polyethylene glycol (PEG 400) in concentrations of 5% and 10%, on the in-vitro drug release was investigated. Thermodynamics of the in-vitro release of Aceclofenac from Eudragit patches were also studied. The anti-inflammatory effect of the selected Aceclofenac Eudragit patches was determined in male albino rats, using paw edema method. The results of the in-vitro release show that, Eudragit patches of Aceclofenac had an acceptable % drug release after 60 minutes and the increase of hydrophilic plasticizers PG or PEG concentrations form 5% to 10% is accompanied by an increase in drug release. The release of drug from all investigated Eudragit patches follows zero order kinetic and it increases linearly as a function of temperature. The free energy (rG) values of drug release are negative for all Eudragit patches and the best thermodynamically stable patch was L100+10% PG, which was chosen for further pharmacodynamic evaluation of Aceclofenac anti-inflammatory activity. The results show that in all treated rat groups there are significant inhibition in edema thickness, produced by carrageenan when compared with the non-treated group. This inhibition in edema is statistically significant at P < 0.05. It was also observed, that the group pretreated with water for 30 hours prior to the experiment showed the highest percent edema inhibition, followed by group pretreated with isopropyl myristate (IPM). This study demonstrates the feasibility of formulating Aceclofenac into transdermal patches using Eudragit L100+10% PG to deliver it as part of inflammatory management.

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-PS-000066
Title: Sedative and anticonvulsant activities of the methanol leaf extract of Ficus hispida Linn.---- vol1 issue 1 2009 [DIT]
Category: Pharmacological Screening
Section: Research Article
Country: India
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The central nervous system (CNS) depressant and anticonvulsant activities of the methanol leaf extract of Ficus hispida Linn (FH) were investigated on various animal models including pentobarbitone sleeping time and hole-board exploratory behaviour for sedation tests, and strychnine, picrotoxin, and pentylenetetrazole-induced convulsions in mice. FH (200 and 400mg/kg, p.o.), like chlorpromazine HCl (1mg/kg, i.m.), produced a dose-dependent prolongation of pentobarbitone sleeping time and suppression of exploratory behaviour. FH (200 and 400mg/kg) produced dose-dependent and significant (P < 0.05) increases in onset to clonic and tonic convulsions, and at 400mg/kg, showed complete protection against seizures induced by strychnine and picrotoxin but not with pentylenetetrazole. Acute oral toxicity test, up to 14 days, did not produce any visible signs of toxicity. These results suggest that potencially antiepileptic compounds are present in leaf extract of FH that deserve the study of their identity and mechanism of action.

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-PS-000067
Title: Protective effect of ethanolic extract of stem bark of Ailanthus excelsa Roxb. against CCl4 induced hepatotoxicity in rats------------VOL1 ISSUE 1,2009,[DIT]
Category: Pharmacological Screening
Section: Research Article
Country: India
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The present study was carried out to evaluate the hepatoprotective effect of ethanolic extract of stem bark of Ailanthus excelsa, Roxb. in Wister albino rats by inducing liver damage by carbon tetra chloride (CCl4). The ethanolic extract at a oral dose of 200mg/kg exhibited significant (p<0.001) hepatoprotective effect by lowering serum enzyme levels of glutamic oxaloacetic transaminase (SGOT), glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin (TB). These observations were supplemented by histopathological examination of liver section. Silymarin was used as positive control.

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-PS-000069
Title: Synthesis and Screening of Some New 2-Amino Substituted Benzothiazole Derivatives for Antifungal Activity
Category: Pharmacological Screening
Section: Research Article
Country: India
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Some new 2-Amino substituted- benzothiazole (A1-7) were synthesized by treating with KSCN in presence of glacial acetic acid and with different Substituted aniline. Structures of the synthesized compounds were established on the basis of Melting Point, TLC, and IR spectral data. The anti-fungal activity of the synthesized compounds was evaluated by disc diffusion method.

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-CPS-000070
Title: In silico prediction of selected pharmacokinetic and toxicity properties of some neuroactive steroids
Category: Chemistry and Parallel Synthesis
Section: Research Article
Country: India
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Selected pharmacokinetic and toxic properties of some neuroactive steroids derived from pregnanolone and alphaxalone were predicted by in silico methods.Pregnanolone and alphaxalone were selected as lead molecules and a series of drug-like molecules derived from them were generated. Their pharmacokinetic and toxicity properties were calculated through the ADME and Tox boxes web version of pharma algorithms and ACD labs Chem. Sketch software version 12.0.All drug-like neuroactive steroids were predicted to be less toxic(LD50900 to 1020 mg/kg and 940 to 1020 mg/kg) with an enhancement in lipophilicity (c log P 3.31 to 4.73 and 5.06 to 6.41),protein binding (64% to 91% and 56%to 92%) and oral bioavailability(64% to 88% and 52% to 90%).From this study, it can be concluded that all the drug-like neuroactive steroids possess marked lipophilicity, rate of absorption, volume of distribution, protein binding and oral bioavailability.

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-DFP-0000853
Title: Vitex agnus castus Molecular Marker Compounds Extraction and Optimization Using HPLC with ELS Detector
Category: Drugs from Plants
Section: Research Article
Country: India
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Vitex agnus castus extracts in different solvent ratios were analyzed using High Performance Liquid Chromatography (HPLC) with Evaporative Light Scattering Detector (ELSD). The markers of our interest in Vitexagnus castus are Agnuside, Casticin and Vitexyl acetone. To correlate the retention time of the molecular marker compounds with Vitex agnus castus extract were compared with standard molecular markers of Agnuside, Casticin and Vitexyl acetone using same conditions of that of extract and were analyzed statistically. Apart from the results ELS Detector is regarded as a valuable alternative to UV detection system for liquid chromatographic analysis of substances that does not contain a strong chromophore. As the markers do not contain strong chromophore, it is difficult to identify it UV detection system in High performance liquid chromatography. So an alternative is the Evaporative Light scattering Detector which is an effective tool for the identification of the compounds which do not contain chromophores. Present study concludes that ELS Detection system is more efficient than the UV/Vis detection system.

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-PS-0000854
Title: Antioxidant potential of a polyherbal formulation (Diabet) on alloxan induced oxidative stress in rats
Category: Pharmacological Screening
Section: Research Article
Country: India
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Diabet, a polyherbal formulation intended to use for diabetic patients has been screened for antioxidant activity. For antioxidant studies, Diabet was administered orally for 30 days at a dose of 500 mg/kg body weight to alloxan induced diabetic male Wistar rats. All the animals were sacrificed on the 31st day and the levels of LPO, SOD, CAT, GPx and GSH in kidney and liver of control and experimental rats were studied. The formulation exhibited significant antioxidant activity showing increased levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and decreased level of lipid peroxidation. These results showed that treatment with Diabet lowers Alloxan induced LPO and alters SOD, CAT, GPx and GSH enzymes to reduce oxidative stress.

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-PS-0000855
Title: Evaluation of Nephroprotective and antioxidant potential of Tragia involucrata
Category: Pharmacological Screening
Section: Research Article
Country: India
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Tragia involucrata (TI) Linn is a shrub belongs to family Ephorbiaceae widely distributed in the Indian subcontinent. TI is used for treatment of various diseases including eczema, inflammation, superficial skin infections. Juice from its leaves is commonly used for illnesses including liver and renal conditions in the Asian subcontinent. The aim of this study was to investigate the nephroprotective and antioxidant activities of ethanol extract of TI at two dose levels of 250 and 500 mg/kg B/W on acetaminophen (APAP) induced toxicity in male albino rats. APAP significantly increased levels of serum urea, hemoglobin (Hb), total leukocyte count, packed cell volume,creatinine, , DLC, and mean corpuscular volume, raised body weight, and reduced levels of neutrophils, mean corpuscular Hb content, mean corpuscular hematocrit, granulocytes, uric acid, and platelet Concentration. TI inhibited the hematological effects of APAP. TI significantly increased activities of renal superoxide dismutase, catalase, glutathione, and glutathione peroxidase and decreased malondialdehyde content of APAP-treated rats. Apart from these, histopathological changes also showed the protective nature of the TI extract against APAP induced necrotic damage of renal tissues. In conclusion it was observed that the ethanol extract of AC conferred nephroprotective and antioxidant activities by histopathological and biochemical observations against APAP induced renal damage in rats.

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-PS-0000858
Title: Antifungal activity of stem bark of Kigelia pinnata Linn.
Category: Pharmacological Screening
Section: Research Article
Country: India
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The effect of petroleum ether, chloroform and methanol extract of stem bark of Kigelia pinnata was investigated in different fungus i.e. Cryptococcus neoformans, Candida tropicalis, Trychophyton rubrum, Microsporum furfure, Epidermophyton floccosum to evaluate the antifungal activity. For this evaluation Sabouraud’s glucose broth media was used. All the three extracts exhibited antifungal activity. The chloroform extract showed significant antifungal activity; where as the petroleum ether and methanolic extract showed weak antifungal activity.

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-PS-0000859
Title: Free radical scavenging and insecticidal activity of Elaeagnus kologa Schldl.
Category: Pharmacological Screening
Section: Research Article
Country: India
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Free radicals contribute to more than one hundred disorders in humans. Mosquitoes are the most important single group of insects acting as vector for many tropical and subtropical diseases. The present study was conducted to screen various solvent extracts of Elaeagnus kologa Schldl. for Antioxidant activity by DPPH radical scavenging assay and insecticidal activity against second instar larvae of Aedes aegypti. The extracts have exhibited concentration dependent radical scavenging activity. Among the extracts, methanol extract exhibited high free radical scavenging activity. A concentration dependent larval mortality was observed in all the extracts. The larval mortality was recorded as 100% in the case of 15 and 20mg/ml of methanol, ethyl acetate and acetone extracts. The radical scavenging and insecticidal activity could be attributed to the presence of phytochemicals in the solvent extracts.

Journal: Drug Invention Today , Volume: 1, Issue: 1.
Article Id: JPRS-PS-0000860
Title: Studies on diuretic and laxative activity of bark extracts of Neolamarckia cadamba (Roxb.) Bosser
Category: Pharmacological Screening
Section: Research Article
Country: India
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The diuretic and laxative activity of various extracts of the barks of Neolamarckia cadamba (Roxb.) Bosser (Family: Rubiaceae) were studied in Wistar albino rats. Furosemide (10 mg/kg, p.o.) and agar-agar (300 mg/kg, p.o.) were used as reference standards respectively for activity comparison. The methanol extract significantly increased the urinary out put as well as urinary electrolyte concentration at the tested dosage regimen that is comparable with the reference standard except in increasing the urinary out put. The chloroform extract produced significant laxative activity. Presence of different phytoconstituents in various extracts of N. cadamba may be responsible for the specific activities.