Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . 
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.897 as on date (08.05.2017)
  Scopus Indexed ( link http://www.scimagojr.com/journalsearch.php?q=21100202909&tip=sid&clean=0)
Journal Metrics for this   Drug Invention Today (Source ID: 21100202909): 2014 (SNIP) Source Normalized Impact Per Paper : 0.402; SCImago Journal Rank (SJR):0.301; Impact Per Publication : 0.517 (Top level : Life Science)
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Manuscripts Published

Journal: Drug Invention Today , Volume: 1, Issue: 2.
Article Id: JPRS-DFA-0000866
Title: Development and validation of a RP-HPLC method for quantification of rottlerin in Kamala (Mallotus philppinensis)
Category: Drug or Formulation Analysis
Section: Research Article
Country: India
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Kamala is orange red powder consisting the glands and hair covering the fruit of Mallotus philppinensis Muell. (Euphorbiaceae), a small tree widely distributed throughout India up to an attitude of 1500 m. It is indigenous to southeastern Asia and find wild throughout tropical Asia, Australia and Philippines. In the indigenous system of medicine, Kamala is used as anthelminitic and cathartic. Kamala powder is used in external application for parasitic affection of the skin and also an aphrodisiac, lithotropic, and stypic. Kamala powder is also used as an antiseptic in blisters in the ears. The seed and fruit powder are generally used for urinary and menstrual disorders. A selective, precise and accurate Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method has been developed for the quantification of Rottlerin in kamala. The use of reverse phase C18 column using gradient mobile phase of acetonitrile and water enabled the efficient separation of the chemical markers within a 22 minute analysis. Validation of method performs in order to demonstrate its selectivity, accuracy, precision, repeatability and recovery study. The proposed RP-HPLC method was found to be simple, precise and accurate and can be used for the quality control of the raw materials as well as formulations.

Journal: Drug Invention Today , Volume: 1, Issue: 2.
Article Id: JPRS-MSNS-0000867
Title: Antifungal activity of stem bark of Helicteres isora Linn.
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
Country: India
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The effect of petroleum ether and methanol extract of stem bark of Helicteres isora was investigated in five different fungus i.e. Cryptococcus neoformans, Candida tropicalis, Trychophyton rubrum, Microsporum furfure, Epidermophyton floccosum to evaluate the antifungal activity. For this evaluation Sabouraud’s glucose broth media was used. All the two extracts exhibited antifungal activity. The methanol extracts showed significant antifungal activity; where as the petroleum ether extract showed weak antifungal activity.

Journal: Drug Invention Today , Volume: 1, Issue: 2.
Article Id: JPRS-PS-0000868
Title: Antimycotic activity of the componenets of Abutilon indicum (Malvaceae)
Category: Pharmacological Screening
Section: Research Article
Country: India
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The search for novel antifungal agents relies in great part on ethnobotanical information and ethnopharmacologic exploration. Methanol extracts provide a more complete extraction, including less polar compounds, and many of these extracts have been found to possess antifungal properties. Methanolic extracts of various parts of Abutilon indicum were tested for their ability to inhibit the aetiological agents of dermal fungal infections in humans. The screening for the antimycotic activity was performed by testing Minimum Inhibitory concentration and Disc diffusion method. Thin layer chromatographic analysis of plant extract used to purify the flavonoid content of plant parts. Quercetin present in these extracts was separated. Methanolic extract of leaves of Abutilon indicum shows remarkable antifungal activity against Trichophyton rubrum. This study provides a sample large enough to determine the antimycotic properties of A. indicum and suggest further studies for a possible therapeutic use.

Journal: Drug Invention Today , Volume: 1, Issue: 2.
Article Id: JPRS-D(DD)-0000869
Title: Optimization of mouth dissolving meloxicam tablets prepared by sublimation technique
Category: Drug (Discovery/Development)
Section: Research Article
Country: India
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The aim of this investigation was to develop mouth dissolving tablets of Meloxicam. Granules containing Meloxicam, menthol, crospovidone and mannitol were prepared by wet granulation technique. Menthol was sublimed from the granules by exposing the granules to vacuum. The porous granules were then compressed in to tablets. Alternatively, tablets were first prepared and later exposed to vacuum. The tablets were evaluated for percentage friability and disintegration time. A 32 full factorial design was applied to investigate the combined effect of two formulation variables: amount of menthol and crospovidone. The results of multiple regression analysis indicated that for obtaining mouth dissolving tablets; optimum amount of menthol and higher percentage of crospovidone should be used. Surface response plots are also presented to graphically represent the effect of the independent variables on the percentage friability and disintegration time. The validity of a generated mathematical model was tested by preparing a checkpoint batch. Sublimation of menthol from tablets resulted in rapid disintegration as compared with the tablets prepared from granules that were exposed to vacuum. Hence, it was concluded that mouth dissolving tablets with improved meloxicam dissolution could be prepared by sublimation of tablets containing suitable subliming agent.

Journal: Drug Invention Today , Volume: 1, Issue: 2.
Article Id: JPRS-PS-0000870
Title: Analgesic, Antipyretic and Anti-inflammatory Effect of the Whole Plant Extract of Desmostachya bipinnata Stapf (Poaceae) in Albino Rats
Category: Pharmacological Screening
Section: Research Article
Country: India
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Analgesic, Antipyretic and anti-inflammatory effect of petroleum ether, benzene chloroform, ethanol and aqueous extract of the whole parts of Desmostachya bipinnata Stapf (Poaceae) was investigated in albino rats. Animals were given a subcutaneous injection of 12% w/v suspension of yeast (1ml /100gm Body weight) suspended in 0.5% w/v methylcellulose solution which leads to pyrexia. Oral administration of petroleum ether, chloroform, ethanol and aqueous extract of the whole parts of Desmostachya bipinnata Stapf (Poaceae) at a dose 300 mg/ kg body weight into six groups of animal for both the activities were shown significantly reduce the elevated body temperature of rat which was compared with standard paracetamol (marketed product) and diclofenac sodium respectively. The anti-inflammatory activity was evaluated by using Digital plethysmometer. The study was carried out using dose of 300 mg/kg orally. All the extracts produced statistically significant and dose dependent inhibition of edema induced by carrageenan at all doses when compared to the control groups.

Journal: Drug Invention Today , Volume: 1, Issue: 2.
Article Id: JPRS-DFA-0000871
Title: RP-HPLC method for the estimation of tamsulosin hydrochloride in bulk and tablet dosage form
Category: Drug or Formulation Analysis
Section: Research Article
Country: India
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The Present work describes a simple reverse phase HPLC method for the estimation of Tamsulosin hydrochloride in bulk and tablet dosage form. The estimation was carried out on ODS,Phenomonex,C-18 (250x4.6 mm,5μ) column using a mobile phase consisting of sodium dihydrogen orthophosphate buffer-Acetonitrile (70:30).The eluent was monitored at 280 nm. The results have been validated statistically and recovery studies confirmed the accuracy of proposed method.

Journal: Drug Invention Today , Volume: 1, Issue: 2.
Article Id: JPRS-CPS-0000861
Title: Impurity profile- A review
Category: Chemistry and Parallel Synthesis
Section: Review Article
Country: India
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Impurity profiling is the common name of a group of analytical activities, the aim of which is the detection, identification/structure elucidation and quantitative determination of organic and inorganic impurities, as well as residual solvents in bulk drugs and pharmaceutical formulations. Since this is the best way to characterize the quality and stability of bulk drugs and pharmaceutical formulations, this is the core activity in modern drug analysis. Due to the very rapid development of the analytical methodologies available for this purpose and the similarly rapid increase of the demands as regards the purity of drugs it is an important task to review a summary of the problems and the various possibilities offered by modern analytical chemistry for their solution. Various regulatory authorities like ICH, USFDA, Canadian Drug and Health Agency are emphasizing on the purity requirements and the identification of impurities in Active Pharmaceutical Ingredient’s (API’s). Qualification of the impurities is the process of acquiring and evaluating data that establishes biological safety of an individual impurity; thus, revealing the need and scope of impurity profiling of drugs in pharmaceutical research. Identification of impurities is done by variety of Chromatographic and Spectroscopic techniques, either alone or in combination with other techniques. There are different methods for detecting and characterizing impurities with TLC, HPLC, HPTLC, AAS etc. Conventional Liquid Chromatography, particularly, HPLC has been exploited widely in field of impurity profiling; the wide range of detectors, and stationary phases along with its sensitivity and cost effective separation have attributed to its varied applications. Among the various Planar Chromatographic Methods; TLC is the most commonly used separation technique, for isolation of impurities; due to its ease of operation and low cost compared to HPLC. An advancement of thin layer chromatography HPTLC is a well-known technique for the impurity isolation.Headspace GC is one of the most preferred techniques for identification of residual solvents. The advent of hyphenated techniques has revolutionized impurity profiling, by not only separation but structural identification of impurities as well. Among all hyphenated techniques, the most exploited techniques, for impurity profiling of drugs are LC-MS-MS, LC-NMR, LCNMR- MS, GC-MS, and LC-MS.

Journal: Drug Invention Today , Volume: 1, Issue: 2.
Article Id: JPRS-PS-0000862
Title: In vitro and in vivo evaluation of immunomodulatory activity of methanol extract of Momordica charantia fruits
Category: Pharmacological Screening
Section: Research Article
Country: India
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The fruits of Momordica charantia have been traditionally used in India and other Asian countries. The methanol extract of Momordica charantia fruits (MCM) was evaluated for immunomodulatory activity using in vitro and in vivo methodologies. Effect of extract was evaluated at various concentrations (832 – 6.5 μg/ml) for secretion of mediators like nitric oxide, superoxide, lysosomal enzyme and myeloperoxidase activity of isolated murine peritoneal macrophages. The extract showed stimulation of nitric oxide, lysosomal enzyme and myeloperoxidase activity. The extract was also evaluated for in vivo phagocytic activity by carbon clearance assay in mice and it showed significant increase in the phagocytic index at 100, 200 and 400mg/kg dose. The effect of the extract on delayed type hypersensitivity (DTH) and antibody titre assay were evaluated in ovalbumin immunized mice. MCM showed no significant effect on DTH response but significant stimulation of antibody titer at 200 and 400mg/kg dose. The effect of the extract in cyclophosphamide induced myelosuppressed mice was not significant. The results suggest that the extract stimulated non-specific murine immune system, both in vitro and in vivo.

Journal: Drug Invention Today , Volume: 1, Issue: 2.
Article Id: JPRS-PS-0000863
Title: Anti-hyperglycemic activity of methanolic extract of Salacia fruticosa leaves in alloxan induced diabetic rats
Category: Pharmacological Screening
Section: Research Article
Country: India
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The aim of the present study was to evaluate the anti hyperglycemic activity of methanolic extract of leaves of Salacia fruticosa (Family:Hippocrataceae) in alloxan induced diabetic rats. The hyperglycemic rats were divided into different groups and were treated with methanolic extract of S. fruticosa at a dose of 125 & 250mg/kg. Treatment with extract produced a significant dose dependent reduction in blood glucose levels and this anti hyperglycemic activity was comparable with the reference standard, metformin. The results of the present study revealed the anti-diabetic activity of methanolic extract of leaves of Salacia fruticosa in alloxan induced diabetic rats.

Journal: Drug Invention Today , Volume: 1, Issue: 2.
Article Id: JPRS-DRP-0000864
Title: Effect of manufacturing conditions on physico-chemical characteristics and drug release profiles of aceclofenac sodium microbeads
Category: Drug Release Profiles
Section: Research Article
Country: India
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The present study reports the optimization of sustained release microbeads of aceclofenac sodium were prepared by ionotropic gelation technique, using different variables such as drug-polymer ratios, concentration of cross-linking agent, cross-linking time. The effects of these processing variables were evaluated on physicochemical properties and drug release potential of microbeads. .The shape and surface characteristics were determined by scanning electron microscopy (SEM). While increasing in the concentration of sodium alginate dispersion increased sphericity, size distribution, flow properties, mean particle size, swelling ratio and drug entrapment efficiency. While increasing cross-linking time was significantly decreases the mean particle size. The mean particle sizes of microbeads were found to be in the range 596.45±1.04 to 880.10±0.13μm. The drug entrapment efficiency was obtained in the range of 63.24-98.90%w/v. No significant drug-polymer interactions were observed in FT-IR studies. In-vitro drug release profile of aceclofenac sodium from microbeads was examined in simulated gastric fluid pH1.2 for initial 2h, mixed phosphate buffer pH 6.8 up to 6h and simulated intestinal pH 7.2 at end of 24h. The release of drug from the microbeads was pH dependent, showed negligible drug release in pH1.2. Under neutral conditions the beads will swell and the drug release depend on swelling and erosion process resulting optimum level of drug released in a sustained manner and exhibited zero-order kinetics. Aceclofenac sodium microbeads prepared by ionotropic gelation method using natural polysaccharide like sodium alginate showed a satisfactory sustained release profile and minimizing dose related side effects. The entire process is feasible in an industrial scale and
demands pilot study.

Journal: Drug Invention Today , Volume: 1, Issue: 2.
Article Id: JPRS-PS-0000865
Title: Antidepressant activity of the ethanolic extract of Albizzia lebbeck (Linn) bark in animal models of depression
Category: Pharmacological Screening
Section: Editorial
Country: India
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Objectives: The present study was designed to investigate the antidepressant effects of Albizzia lebbeck bark in various animal depression models.Materials and Methods: The alcoholic extract (70% v/v ethanol) of Albizzia lebbeck bark (200 & 400 mg/kg. p.o) was administered once daily for seven successive days to separate groups of young male swiss albino mice. The immobility periods of control and treated mice were recorded in two behavioral despair models forced swim test (FST), tail suspension test (TST) and the effect of extract on locomotor function of mice was studied using actophotometer. The antidepressant-like effect of tested drug was compared to that of imipramine (15 mg/ kg. p.o) and fluoxetine (20mg/kg.p.o). Results: The bark extract at doses of 200 and 400 mg/kg significantly decreased the duration of immobility time in a dose dependent manner in both FST and TST. The extract did not show significant effect on locomotor activity of mice. The efficacy of tested extract was found to be comparable to that of imipramine and fluoxetine. Conclusion: Our results suggested that the ethanolic extract of Albizzia lebbeck bark exerts antidepressant-like effect.