Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . 
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.897 as on date (08.05.2017)
  Scopus Indexed ( link http://www.scimagojr.com/journalsearch.php?q=21100202909&tip=sid&clean=0)
Journal Metrics for this   Drug Invention Today (Source ID: 21100202909): 2014 (SNIP) Source Normalized Impact Per Paper : 0.402; SCImago Journal Rank (SJR):0.301; Impact Per Publication : 0.517 (Top level : Life Science)
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Manuscripts Published

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-D(DD)-0000875
Title: Orally Disintegrating Tablets: A Review
Category: Drug (Discovery/Development)
Section: Editorial
Country: India
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Over a decade, the demand for development of orally disintegrating tablets (ODTs) has enormously increased as it has significant impact on the patient compliance. Orally disintegrating tablets offer an advantage for populations who have difficulty in swallowing. Prescription ODT products initially were developed to overcome the difficulty in swallowing conventional tablets with water among pediatric, geriatric, and psychiatric patients with dysphagia. Today, ODTs are more widely available as over-the-counter products for the treatment of allergies and cold and flu symptoms. Technologies used for manufacturing of orally disintegrating tablets are either conventional technologies or patented technologies. In conventional freeze drying, tablet molding, sublimation, spray drying etc. and in patented Zydis technology, Orasolv technology, Durasolv technology, Wowtab technology, Flashdose technology are important. Important ingredients that are used in the formulation of ODTs should allow quick release of the drug, resulting in faster dissolution. Evaluation of these tablets are done by following weight variation, friability, tensile strength, wetting time, water absorption ratio, In vitro dispersion time and dissolution test.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-Other-0000872
Title: The oil Palm tree: A renewable energy in poverty eradication in developing countries
Category: Others ( DIT Related Science )
Section: Editorial
Country: India
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This paper highlights the role of the oil palm tree (Elaeis guineensis) as a renewable energy in poverty eradication in developing countries. Many uses of the oil palm are known. This paper describes the processing of palm oil fruits for the extraction of both palm oil and palm kernel oil at the small-scale level. Palm oil and palm kernel oil are the primary major products of the oil palm tree. These oils also are raw materials for the production of a variety of products such as cooking oils, biodiesel, edible fats in the confectionery and bakery trades, ice-cream, mayonnaise, toilet soap, powder detergents, pomades, candles, etc. The palm kernel cake is a major ingredient in the livestock feed manufacture. Palm wine, an alcoholic beverage produced from the sap obtained by the tapping of the male inflorescence is sweet when fresh and sugar can be produced from it. Gin is distilled from the fermented wine. The trunk and the leaflet of the tree are also used for the production of various materials. The sale of all these products of the palm tree will yield cash (money) and social recognition for the oil palm tree farmer. It is also argued that adequate support from the government in terms of research in oil palm, training of farmers, provision of processing facilities, and social amenities will help to promote the quality of products and increase the earnings of the oil palm farmers and processors. In order to attract the land-less farmers, incentives are should be offered to them in the shape of land and seeds at an affordable price. They should also be provided road approach, drinking water facility, low cost sanitation, primary education, basic health facilities, oil extraction mill and market to the nearest township to enable them to sell the fruit, seed, oil and inter-cropped vegetables. These facilities if provided would be result oriented, functional and economically viable thereby eradicating poverty in the society.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-D(DD)-0000873
Title: Ocular Inserts : A Review
Category: Drug (Discovery/Development)
Section: Review Article
Country: India
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Ophthalmic drug delivery is one of the most interesting and challenging endeavors facing the pharmaceutical scientist. The anatomy, physiology and biochemistry of the eye render this organ exquisitely impervious to foreign substances. The challenge to the formulator is to circumvent the protective barriers of the eye without causing permanent tissue damage. Newer delivery system is being explored to develop extended duration and controlled release strategy. Some of the newer, sensitive and successful ocular delivery system like inserts, biodegradable polymeric system, and collagen shields are being developed in order to attain better ocular bioavailability and sustained action of ocular drugs.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-D(DD)-0000874
Title: Niosomes: The ultimate drug carrier
Category: Drug (Discovery/Development)
Section: Review Article
Country: India
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Niosomes or non-ionic surfactant vesicles are microscopic lamellar structures formed on admixture of non-ionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. The method of preparation of niosome is based on liposome technology. The basic process of preparation is the same i.e. hydration by aqueous phase of the lipid phase which may be either a pure surfactant or a mixture of surfactant with cholesterol. After preparing niosomal dispersion, unentrapped drug is separated by dialysis centrifugation or gel filtration. A method of in-vitro release rate study includes the use of dialysis tubing. Niosomes are unilamellar or multilamellar vesicles formed from synthetic non-ionic surfactants. Niosomal drug delivery is potentially applicable to many pharmacological agents for their action against various diseases.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-MSNS-0000876
Title: Bactericidal activities of different Medicinal plants extracts against Ocular pathogen viz Corynebacterium macginleyi
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
Country: India
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In this contemporary investigation bio-control of ocular pathogen i.e. Corynebacterium macginleyi was achieved by methanol, chloroform and hexane extracts of forty different medicinal plants using agar well diffusion method. Among the forty selected plants, methanolic extracts of thirty six plants given remarkable bioactivity than chloroform and hexane extracts against C. macginleyi. The methanolic extracts from Terminalia catappa, Terminalia chebula, Rosa indica, Albizia lebbeck, Butea monosperma showed maximum activity. Hibiscus rosasinensis, Justicia adhatoda, Physalis minima and Pongamia pinnata did not exhibit antibacterial activity at the condition studied. Among the forty plants studied 90 % of the plants had antibacterial activity while the remaining 10% had no antibacterial activity.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-BRPT-0000877
Title: Conservation of an endangered medicinal plant Centella asiatica through Plant Tissue culture
Category: Biotechnology & Related Pharmaceutical Technology
Section: Research Article
Country: India
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Centella asiatica is an endemic herbaceous plant with great medicinal value. Medicinal properties of the plant has led to it’s over exploitation coupled with inadequate cultivation and unsatisfactory attempts for its replacement, the wild stock of this species has been markedly exhausted and now it is listed as threatened species. Hence, there is an urgent necessitate to safeguard this precious germplasm. Plant tissue culture has proved to be helpful in conserving threatened plant species. In this direction, in the present study, an efficient protocol was developed for callus induction and plantlet regeneration from nodal explants of Centella asiatica. Well-organized plant regeneration was achieved on MS medium containing different concentrations and combinations of growth regulators. MS medium supplemented with 4 mg/l and NAA in combination with 2 mg/l 2, 4-D proved effective for callus induction, with this combination we achieved a frequency of 92% and BAP 1.5 mg/l and KN 1.5 mg/l was effective for regeneration response.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-PS-0000878
Title: A comparative study of Aloe, Kundru and Neem as an antidiabetic agent
Category: Pharmacological Screening
Section: Research Article
Country: India
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Natural products compounds discovered from medicinal plants (and their analogues there of) have provided numerous clinically useful drugs and still remain as an essential component in the search for new medicines. So, these traditionally used plants can be exploited effectively in order to find New Chemical Entity for treatment of diabetes. Present studies besides confirming hypoglycemic activities of the experimental herbal samples; help identify more potent indigenous hypoglycemic herbs (in crude extract) from the comparative study of the reported experimental results. Particularly in preparation of polyherbal antidiabetic formulation. Chronic administration of different plant extracts (200mg/kg)for 14 days reduces the blood glucose level of the diabetes induced animals as compared to diabetic control group. There was significant decrease in the blood glucose level in the 7th[p<0.01] and 14th [p<0.001] days of the diabetes induction, showing antidiabetic effect individually. The peak reduction in the blood glucose level was found by the MG-02 extract treated animal. Plant extracts were Chronically administered (200mg/kg ) to the diabetic induced animals shows significant decrease in the blood glucose level [p<0.001] and the effect was comparable to that of standard antidiabetic drug Glibenclamide. This shows the antidiabetic effect of the different plant extracts.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-PS-0000879
Title: Anti-hyperlipidemic activity of the aqueous extract of the Artocarpus heterophyllus leaves in triton WR-1339 induced hyperlipidemic rats.
Category: Pharmacological Screening
Section: Research Article
Country: India
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Experimental evidences are suggesting that the plasma hypercholestrelomic state is a main contributor of the development of cardiovascular diseases like atherosclerosis.The present study an aqueous extract from Artocarpus heterophyllus leaves was designed to evaluated for its hypocholesterolaemic and hypotriglyceridemic activities. Artocarpus heterophyllus leaf extract has not shown any side effects during acute toxicity studies Hyperlipidaemia was developed by intraperitoneal injection of Triton WR – 1339 400mg/kg.The animals were divided into Normal (CG), Triton treated group (T), Triton plus Atorvastatin, Triton plus herb extract 200 mg/kg, Triton plus herb extract 400 mg/kg, treated groups. Oral administration of Artocarpus heterophyllus leaf extract (200 mg/kg and 400 mg/kg) in both groups At 24 hrs after treatment with TRITON WR 1339 caused a significant decrease in serum lipid parameters like Triglycerides (TG), Cholesterol (CH), LDL- cholesterol, Atherogenic index (AI), LDL/HDL Ratio and Total proteins as like in atorvastatin treated groups. The both extract treated groups and atorvastatin treated group bought about a significant increase in HDL-Cholesterol levels levels. Significant reduction in lipid parameters indicates that this herb may contain products that lowers the Serum lipid concentrations and might be beneficial in treatment of hyperlipidaemia.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-DFA-0000880
Title: Energy Dispersive X-ray Spectroscopy (EDX) analysis of Curculigo orchioides Gaertn. root tubers
Category: Drug or Formulation Analysis
Section: Research Article
Country: India
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Curculigo orchioides Gaertn. (Amaryllidaceae) is an endangered medicinal plant. The root tubers of the plant have been used extensively in India in indigenous medicine. Its root tubers were investigated for its metal mineral content by using Energy Dispersive X-Ray Spectroscopy (EDX). The elemental analysis was performed to estimate eleven numbers of elements (C, O, Mg, Al, Si, Cl, K, Ca, Fe, Cu & Zn). The analysis of EDX showed that root tubers possesses only seven type of essential elements. The root tubers was found deficient in Mg, Al, Si and Fe.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-D(DD)-0000881
Title: Formulation and evaluation of Orodispersible tablets of terbutaline sulphate
Category: Drug (Discovery/Development)
Section: Research Article
Country: India
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Terbutaline sulphate is widely used medicine of bronchial asthma. It is a beta 2 receptor agonist. Orodispersible tablets of Terbutaline sulphate were prepared using superdisintegrants, ac di sol, sod.cmc, alginic acid, chitosan, mcc, as diluents by direct compression method. Twelve formulations were prepared using the superdisintegrants at lower, intermediate, higher concentration. Mannitol is used to enhance the organoleptic properties of tablets. Tablets were evaluated for uniformity of wt, hardness, friability, content uniformity, wetting time, dispersion time, disintegration time and in vitro drug release. All the formulation s showed disintegration time less than less than 35 and drug release by dissolution (100% at the end of 10 mins).

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-PS-0000882
Title: Anti-oxidant activity of the aqueous extract of the Morinda citrifolia leaves in triton WR- 1339 induced hyperlipidemic rats.
Category: Pharmacological Screening
Section: Research Article
Country: India
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Different epidemiological studies have shown that the oxidative stress is one of the major contributor of the development of hyperlipidemia and atherosclerosis. This study was aimed to evaluate the antioxidant activity of aqueous extract from Morinda citrifolia leaves against hyperlipidemic rats. Morinda citrifolia leaf extract has not shown any side effects during acute toxicity studies Hyperlipidemia was developed by intraperitoneal injection of Triton WR – 1339 400mg/kg.The animals were divided into Normal group, Triton treated group (T), Triton plus Atorvastatin, Triton plus herb extract 150 mg/kg, Triton plus herb extract 300 mg/kg, treated groups. Oral administration of Morinda citrifolia leaf extract (150 mg/kg and 300 mg/kg) in both groups At 24 hrs after treatment with TRITON WR 1339 caused a significant decrease in Malondialdehyde levels and significant increase in Superoxide dismutase (SOD), Reduced glutathione, Catalase levels as like in atorvastatin treated groups. Significant reduction in above stated anti-oxidant parameters indicating that this herb may contain products that lowers the oxidative stress and might be beneficial in treatment of hyperlipidemia.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-BRPT-0000883
Title: Carboplatin-mediated changes in the activity levels of steroidogenic marker enzymes, serum hormones and testicular architecture in male rats.
Category: Biotechnology & Related Pharmaceutical Technology
Section: Research Article
Country: India
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Carboplatin (10 mg/ kg body weight) caused significant decrease in the activity levels of steroidogenic marker enzymes such as 3ß-hydroxy steroid dehydrogenase and 17ß-hydroxy steroid dehydrogenase in experimental rats when compared to that of the control rats. In addition, activity levels of serum hormones including LH, FSH and Testosterone were also altered significantly in experimental animals. Besides, causing significant alterations in the activity levels of steroidogenic marker enzymes, and serum hormones, carboplatin treatment also caused changes in testicular architecture in rats.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-DFP-0000884
Title: In vitro Bioautography of different Indian Medicinal plants
Category: Drugs from Plants
Section: Research Article
Country: India
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In vitro screening of ethanolic crude extracts of Indian medicinal plants Terminalia chebula, Centella asatica, Solanum xanthocarpum were studied that have been popularly used as folk medicines. The main characteristic of an antioxidant is its ability to trap free radicals and also reduce the risk of chronic diseases including cancer, central nervous system injury, arthritis and heart diseases. Scientific information on antioxidant properties of various natural sources is still rather scarce. A variety of free radical scavenging antioxidants are found in plants. The results provided evidence that the studied plants might indeed be potential sources of natural antioxidant and antimicrobial agents.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-D(DD)-0000885
Title: Evaluation of binding properties of Moringa oleifera gum in the formulation of paracetamol tablets
Category: Drug (Discovery/Development)
Section: Research Article
Country: India
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Plant gums and mucilage are being used in Pharmaceuticals and in other various industries due to their abundance in nature, safety and low cost. Binding agents are used to impart the structural strength required during the processing, handling and packaging of tablets. In view of the importance of binders in pharmaceuticals for the manufacture of tablets and capsules, gum isolated from the stem of Moringa oleifera have been evaluated for its binding properties in the formulation of conventional Paracetamol tablet (500mg) containing 8%, 10% and 12% binding concentration. The binding property of gum was evaluated in relation to conventional binder like gelatin at different parameter like percentage of fines, tablet hardness, disintegration time, dissolution and friability. Studies showed that increase in binding concentration of M.oleifera gum from 8% to 12% decreases the percentage of fine, increases the hardness, increases the disintegration time, decreases the percentage of friability and decreases % cumulative release. The binder-excipients interaction study was also carried out by using FTIR i.e. by KBr pellet method which showed that M.oleifera gum is compatible with drug and all excipients in the formulation. It may be concluded from the studies that increase in binding concentration decreases drug release hence this gum can be used to formulate sustained/controlled release tablet formulation, since it shows better tabletting characteristics have high potential for the substitution of expensive binder.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-Other-0000886
Title: Characterization of marine Streptomyces from Visakhapatnam coast
Category: Others ( DIT Related Science )
Section: Research Article
Country: India
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Six unidentified gram-positive, filamentous organisms recovered from the marine sediments of visakhapatnam coast were characterized by morphological, cultural, physiological and biochemical studies and assessed for their antimicrobial activity. Chemotaxonomic investigations revealed the presence of L, L- diaminopimelic acid, glycine and xylose in whole-cell hydrolysates of isolates, which indicated cell wall type 1, consistent with the genus Streptomyces. Out of 6 isolates, 4 isolates exhibited broad spectrum of antibacterial activity and two isolates showed strong antifungal activity. As the isolates differed from the standard cultures in characteristics of the spore bearing apparatus and other taxonomic cultures in characteristics, they are classified as novel strains of the genus Streptomyces.

Journal: Drug Invention Today , Volume: 2, Issue: 1.
Article Id: JPRS-CPS-0000913
Title: Combinatorial Chemistry: A review
Category: Chemistry and Parallel Synthesis
Section: Research Article
Country: India
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Combinatorial chemistry is a new technique which have been used for synthesis of defined compounds having screened for pharmacological activity. This technique leads to synthesis of pharmacologically, biologically active compounds and their QSAR studies.This article emphasizes the different methods of combinatorial chemistry concept and their methodology.