Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . 
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.897 as on date (08.05.2017)
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Journal Metrics for this   Drug Invention Today (Source ID: 21100202909): 2014 (SNIP) Source Normalized Impact Per Paper : 0.402; SCImago Journal Rank (SJR):0.301; Impact Per Publication : 0.517 (Top level : Life Science)
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Manuscripts Published

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-D(DD)-0000903
Title: Fast Dissolving Tablet: As A Potential Drug Delivery System
Category: Drug (Discovery/Development)
Section: Review Article
Country: India
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Tablet is the most popular dosage form among from all existing dosage form. but in some instances due to the large size of dosage forms, and in case of uncooperative, pediatric and dysphasia patients, it may create some problems, to overcome this problems, a new form of dosage form is developed, which is known as first dissolving tablet or mouth dissolving tablet. These tablets are the advanced dosage form which is dissolve with in few seconds after placing on the tongue. Fast dissolving tablets have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance. Preparing pharmaceuticals acceptable dosage form demands clear understanding details about the Fast dissolving tablet or Mouth dissolving tablet. This review discusses the method of preparation, properties, advantages, mechanisms; drugs to be incorporated in the mouth dissolving tablet and evaluation of the mouth dissolving tablet are emphasized.

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-DFP-0000918
Title: A review on Calotropis procera Linn and its Ethnobotany, Phytochemical, Pharmacological profile
Category: Drugs from Plants
Section: Review Article
Country: India
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Calotropis procera Linn is small, erect and compact shrubs, which is used in several traditional medicines to cure various diseases. This shrub has been known to posses’ Analgesic, Antitumor, Antihelmintic, Antioxidant, Hepatoprotective, Inflammatory, Antidiarrhoeal, Anticonvulsant, Antimicrobial, Oestrogenic, Antinociceptive, and Antimalarial activity. A wide range of chemical compounds including Benzoyllineolone, benzoylisolinelone and ß-amyrin. The root bark contains the calotropoleanyl ester, proceroleanenol A and proceroleanenol B. The latex contains the calactin, calotropin, uscharin, sitosterol, and calotoxin. The presented review summarizes the information concerning the ethnobotany, pharmacological, phytochemistry, biological activity and toxicity of the calotropis procera shrubs.

Cite this article as: Ajay K. Meena , Ajay K. Yadav , Uttam S. Niranjan , Brijendra Singh , Amit K. Nagariya, Kiran Sharma , Anand Gaurav , Surabhi Sharma and M.M.Rao, A review on Calotropis procera Linn and its Ethnobotany, Phytochemical, Pharmacological profile, Drug Invention Today, Vol.2.Issue 2.February 2010,185-190

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-D(DD)-0000914
Title: Recent advances in self emulsifying drug delivery system - A review
Category: Drug (Discovery/Development)
Section: Review Article
Country: India
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Self-emulsifying drug delivery systems (SEDDS) are usually used to improve the bioavailability of hydrophobic drugs. Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. From time to time many workers have claimed various rational applications of Self-emulsifying formulation for enhancing bioavailability and site-specific targeting of highly lipophilic drugs. SEDDS is ideally an isotropic mixture of oils and surfactants and sometimes co solvents. The multi-component delivery systems have optimized by evaluating their ability to self-emulsify when introduced to an aqueous medium under gentle agitation, and by determination of particle size of the resulting emulsion. Upon per oral administration, these systems form fine (micro) emulsions in the gastrointestinal tract (GIT) with mild agitation provided by gastric mobility. These articles
give an overview of the recent advances in the development of SEDDS and the dosage forms along with the associated problems and the possible future research directions in this field.

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-ADRS-0000915
Title: Review on antifungal activities of Ayurvedic Medicinal Plants
Category: Ayurvedic Drugs Related Study
Section: Review Article
Country: India
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Infectious diseases represent a critical problem to health and they are one of the main causes of morbidity and mortality worldwide. The resistance to antibiotics and with the toxicity during prolonged treatment with several drugs due to this medicinal plants are widely used by the traditional medical practitioners for curing various diseases in their day to day practice. Since ancient times, plants have been an exemplary source of medicine. During the past several years, there has been an increasing incidence of fungal infections due to a growth in immunocompromised population such as organ transplant recipients, cancer and HIV/AIDS patients. The presented review summarizes the information concerning the new profile of antifungal drugs obtaining from medicinal plants.

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-ADRS-0000916
Title: A review on cataract and its herbal treatments
Category: Ayurvedic Drugs Related Study
Section: Review Article
Country: India
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Cataract, called in Sanskrit as linganaasha or timira, is one of the leading causes for blindness today. Cataract is the opacification (light impenetrability) of the lens. In this condition, the lens of the eyes interferes with the eye vision. Since light cannot enter the opaque lens, therefore the eyes fail to give the representation of the objects seen. Plants used in Ayurvedic eye drops formulation are rich source of tannin and tannin like compounds. Antioxidant and antimicrobial properties of ayurvedic eye drops are attributed to the presence of tannins and tannin like compounds. Now-a-days, people increasingly prefer ayurvedic eye drops because it is safe and relatively free from side effect and adverse reactions. Ayurvedic eye drops are known to show antiinflammatory, antioxidant and antimicrobial activity due to their tannin content in aqueous extract. The anticataract efficacy of these preparations was mainly attributed to their antioxidant potential. Various herbal drugs such as Osmium sanctum, Emblica officinalis, Ginkgo biloba etc are used in cataract. The presented review summarizes the information concerning the new profile of anticataract drugs obtained from medicinal plants.

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-MSNS-0000917
Title: Studies on Insecticidal activity and Nutritive composition of a macrolichen Parmotrema pseudotinctorum (des. Abb.) Hale (Parmeliaceae)
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
Country: India
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The present study was carried to determine the nutritive composition and insecticidal activity of a macrolichen Parmotrema pseudotinctorum (des. Abb.) Hale (Parmeliaceae) collected from forest area of Bhadra wildlife sanctuary. The nutritive parameters namely moisture, ash, fat, crude fiber, protein, carbohydrate and mineral contents were determined. The insecticidal efficacy of solvent extracts was determined against second instar larvae of Aedes aegypti. P. pseudotinctorum was found to possess high crude fiber, carbohydrate and protein content. Nutritive value was found to be 336.1 cal/100g. Phosphorus was found to be in high concentration than potassium. A rich amount of iron was detected followed by manganese, copper and zinc. The insecticidal efficacy of solvent extracts was found to be concentration dependent. Among extracts, marked insecticidal activity was observed in case of methanol extract than other extracts. Phytochemical analysis detected tannins and steroids in the methanol extract. Thin layer chromatography revealed the presence of Atranorin and Lecanoric acid. The insecticidal activity of P. pseudotinctorum could be mainly due to constituents present in extracts. The results of this study highlighted the significance of the macrolichen P. pseudotinctorum studied in terms of its rich nutritive composition and justify the possible use of the lichen in reducing problems associated with malnourishment. The extracts of the lichen selected in this study could be used in the control of mosquitoes. Further studies on isolation of active principles and determination of insecticidal activity of them are to be carried out.

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-MSNS-0000919
Title: Antimosquito (Insecticidal) activity of extracts of Hemidesmus indicus and Swertia chirata against Aedes aegypti mosquito larvae- A Comparative Study
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
Country: India
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The present study was carried out to investigate antimosquito (insecticidal) activity of methanol, chloroform and petroleum ether extracts of two medicinal plants Hemidesmus indicus and Swertia chirata against second instar larvae of Aedes aegypti. The insecticidal activity of different concentrations of solvent extracts was found to be dose dependent. Among extracts, H. indicus showed more larvicidal efficacy when compared to S. chirata. Overall, it was found that the chloroform extract was more effective in killing larvae followed by ethanol and petroleum ether extracts. The larvicidal efficacy of solvent extracts may be due to the presence of phytochemicals in the extracts. Further, isolation of active constituents from solvent extracts and determination of insecticidal efficacy of isolated constituents are to be carried.

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-PS-0000920
Title: Evaluation of anti-inflammatory potential of Trigonella foenum-graecum (Fenugreek) seed extracts by using carrageenan induced rat paw edema
Category: Pharmacological Screening
Section: Research Article
Country: India
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The aim of this study was to evaluate the anti-inflammatory potential of Trigonella foenum – graecum (TFG) seed extracts by using carrageenan induced rat paw edema in comparison to established anti-inflammatory drug diclofenac potassium (DIP, 10 mg/kg, p.o.). Successively extracted (aqueous and ethanol) extracts of TFG seeds were administered 1 h prior to inflammation induction in dose range of 50, 100 and 200mg/kg orally. The rat paw edema was induced by injecting 0.1 ml of 1 % w/v carrageenan solution, prepared with normal saline in subplantar region of left hind paw of the rats.Results of these study revealed that the ethanol extract at dose 200 mg/kg shows significant (p<0.01) reduction of inflammation as compared to aqueous extract group animals. Further series of investigations are, however, necessary to explore their mechanism(s) of action involved in this pharmacological activity.

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-PS-0000921
Title: Efficacy of Cynodon dactylon for immunomodulatory activity
Category: Pharmacological Screening
Section: Research Article
Country: India
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Cynodon dactylon (Poaceae) commonly known as arugampul, is a perennial grass, forming thick mats by means of stolons and rhizomes. It is bitter, sharp, hot taste, good odour, laxative, brain and heart tonic, emetic, expectorant, carminative and useful against pains, inflammation and tooth ache. In the present study an attempt has been made to evaluate Cynodon dactylon protein fraction immunomodulatory activity. Cynodon dactylon protein (Cdpf) was administered intraperitonealy at doses of ED50 to healthy Swiss albino mice. Assessment of immunomodulatory activity was carried out by testing the humoral (antibody titre) and cellular (foot pad swelling) immune responses to the antigenic challenges with sheep RBCs and by neutrophil adhesion test. Intraperitonealy administered Cdpf showed a significant increase of test parameters Viz., neutrophil test, Haemagglutinating Antibody Titre (HAT) and Delayed Type Hypersensitivity (DTH) response. In mice immunized with sheep RBC, Cdpf enhanced the humoral antibody response to the antigen and significantly potentiated the cellular immunity by facilitating the food pad thickness response to sheep RBC in sensitized mice. There was increase in immunomodulation, there was significant improvement compared to control group and differences were statistically significant in Cdpf, therefore Cynodon dactylon protein fraction promises strong utility in clinical practice as an effective immunostimulant.

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-PS-0000922
Title: Anxiolytic activity of ethanolic extract of leaves of Ocimum sanctum in rats
Category: Pharmacological Screening
Section: Research Article
Country: India
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Anxiety is a normal emotional behaviour. When it is severe and/or chronic, however, it becomes pathological and can precipitate or aggravate cardiovascular and psychiatric disorders. Although many drugs are available in allopathic medicine to treat anxiety disorders, they produce various systemic side effects or exhibit tolerance upon chronic use. Benzodiazepines (BZDs) are the major class of compounds used in anxiety and they remain the most commonly prescribed treatment for anxiety. However BZDs have many unwanted side effects that prompted many researchers to evaluate new compounds in the hope of identifying other anxiolytics with fewer side effects. In the present study, we have attempted to evaluate the anxiolytic-like activity of ethanolic extract of leaves of Ocimum sanctum(OS) in rats by employing the two pharmacologically validated models, elevated plus maze and bright and dark arena. The rats were divided into five groups, each group containing six animals. The effects of the test drug OS (at 1.75, 4.25 and 8.5 mg/kg doses), the standard anxiolytic, diazepam (1.0 mg/kg) and control group 1%gum acacia(10ml/kg) were assessed after single and repeated dose administration for ten days. The results suggest that, behavioural disinhibitory effects of OS exhibited anxiolytic like activity comparable to diazepam.

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-DFA-0000923
Title: Method development for spherical crystallization of glibenclamide and evaluation of micromeritic properties
Category: Drug or Formulation Analysis
Section: Research Article
Country: India
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Glibenclamide is an anti-diabetic drug with water insolubility and compressibility. The pure drug (Glibenclamide) was converted into spherical crystal agglomerates via the spherical crystallization technique using dichloromethane-water-chloroform solvent system. The various parameters optimized were type, amount and mode of addition of bridging liquid, temperature and agitation speed to get maximum amount of spherical crystals. These were characterized for micromeritic properties (particle size and shape, flow ability), pack ability (bulk density), wet ability (contact angle) and compressibility. It was revealed from the study that spherical agglomerates exhibited improved flow ability, wet ability and compaction behavior.

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-D(DD)-0000924
Title: Formulation, Optimization and Evaluation of Matrix type Transdermal system of Lisinopril Dihydrate Using Permeation Enhancers.
Category: Drug (Discovery/Development)
Section: Research Article
Country: India
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The Lisinopril dihydrate (angiotensin converting enzyme inhibitor) is lysine derivative of enalaprilat and does not require hydrolysis to exert pharmacological activity. It is given orally; suffer severely from hepatic first pass metabolism resulting in bioavailability of 6-60%. To overcome the poor bioavailability of the drug, transdermal patches have been prepared. The present study also aims at optimization of the formulation by incorporating the penetration enhancers in different concentration and ratios. The patches were prepared employing Hydroxy propyl methyl cellulose (HPMC) & Polyvinyl alcohol (PVA) in 1:1 ratio as polymeric matrix using glycerol as plasticizer in 6% concentration. Binary solvent system (Water: Methanol) in the ratio of 70: 30 was taken for the study. The Transdermal devices were fabricated on glass substrate using solvent casting technique. Iso propyl alcohol (IPA) & Oleic acid (OA) were added as the penetration enhancers individually and in blend in different concentrations and ratios. Various physico-chemical evaluatory parameters were carried over prepared patches to ascertain their integrity and physical stability at normal and accelerated temperature conditions.Optimization of the penetration enhancer’s concentration and ratio was done by performing in-vitro diffusion rate studies using Keshary-Chein diffusion cell on Goatskin. The best results in terms of C.P.R. obtained individually through OA & IPA patches were 54% & 70.65% respectively at the highest concentration (15 %) of enhancer employed individually. But when the blend of enhancers is used in lowest concentration of 5 %, they produce the C.P.R. of 84.33 %, which clearly dictates the synergistic effect of the enhancers if used in combination. The rate of drug permeation further increases on increasing the concentration of blend from 5 to 15 %. The drug release from the patches follows Higuchi’s kinetics and gives a linear relation between q (amount released) vs t1/2 (time).

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-BSN-0000925
Title: Effect of Different Biological Membranes on In Vitro Bioadhesion Property
Category: Biomaterials ( Synthetic and Natural )
Section: Research Article
Country: India
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The influence of biological membranes on in vitro bioadhesion property of Carbopol 934P (CP), Polyvinylpyrrolidone (PVP K90) and sodium carboxymethylcellulose (Cekol 10,000) was studied using a texture analyzer equipment. Polymer/biological membrane interaction was significantly influenced by the contact time used during the study. An increase in contact time also increased bioadhesion strength. An intermediate contact time of 180s was deemed to be the most suitable contact time. In addition, different polymers produced different values of bioadhesion strength. Moreover, polymer molecular weight is directly correlated with bioadhesion strength. Biological membrane, such as rabbit gastric mucosa, cow intestine, pig intestine or chicken pouch, is a less significant determinant in affecting the bioadhesion strength as compared to the type of polymer used. Chicken pouch, an easily available and uniform tissue, offers an attractive alternative to be employed as a model biological membrane in bioadhesion study.

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-Qs-0000926
Title: QSAR analysis of structurally similar 1, 3, 4 - oxadiazoles as enzyme tyrosinase inhibitors.
Category: QSAR studies
Section: Research Article
Country: India
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A series of structurally similar 1, 3, 4-oxadiazoles with enzyme tyrosinase inhibitor activity have been subjected for QSAR analysis using V life MDS 3.5 software. The compounds were divided into training and test set. Best QSAR models were selected on the basis of various statistical parameters like square correlation coefficient (r2), cross validated square correlation coefficient (q2), standard error of estimation (SE) and sequential Fischer test (F). 2D QSAR study reveals that tyrosinase inhibitor activity is governed by Alignment Independent (AI) descriptors whereas as per 3D QSAR studies a new compounds, with more electronegative and less bulky substituent, from this series could have better tyrosinase inhibitor activity.

Journal: Drug Invention Today , Volume: 2, Issue: February
Article Id: JPRS-ADRS-0000927
Title: Standardisation of Desmodium gangeticum- A Tradition Ayurvedic Plant
Category: Ayurvedic Drugs Related Study
Section: Research Article
Country: India
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Desmodium gangeticum is a traditional Ayurvedic plant used for centuries as an anthelminthic, anti-catarrahal, diuretic, expectorant, astringent, febrifuge, nervine tonic, anti diarrheal, bronchiodilator, vasopressor, analgesic, antipyretic, cardio tonic, stimulant, antioxidant and antiinflammatory agent. The whole plant, its extract and isolates have been extensively investigated in several laboratories for their different biological activities. In addition researchers have evaluated the anti-inflammatory, antioxidant, immunomodulatory and other pharmacological effects of Desmodium gangeticum preparations/extracts.