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Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . From 2019  Journal will be monthly twice ( vol 11& 12 with 2 Issues per month)
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.895 as on date (09.11.2018)
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Manuscripts Published

Journal: Drug Invention Today , Volume: 4, Issue: June
Article Id: JPRS-PS-00001091
Title: Study of Antinociceptive Effect of Paroxetine and Elucidation of Its Mechanism of Action in Acute Pain in Albino Rats
Category: Pharmacological Screening
Section: Research Article
Author Affiliation: 1Department of Pharmacology, SSIMS & RC, NH4 Bypass Road, Davangere
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Pain is the most common reason patients seek medical care. Increased level of monoamines (serotonin and norepinephrine) in synaptic clefts lead to changes in pain threshold and induce antinociception. The study was carried out to evaluate antinociceptive effect of paroxetine in albino rats and to probe into its possible mechanism of action. Albino rats of either sex of average weight 100-200gms were used. The drugs used were paroxetine 5mg/Kg, pethidine 5mg/Kg(active control), naloxone 5mg/Kg, ondansetron 0.1mg/Kg and normal saline 1ml/Kg. Antinociceptive effect tested by using thermal method i.e. tail flick response. Statistical analyses indicate significant difference between value of control when compared with paroxetine i.e., paroxetine shows antinociceptive effect. The effects of paroxetine were comparable to that of pethidine. Naloxone, an opioid receptor antagonist and Ondansetron, a 5HT-3 receptor antagonist when combined with paroxetine blocked its antinociceptive action. This finding suggests and involvement of serotonergic mechanisms (5-HT3 subtype), and the opioidergic system.