Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . 
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.897 as on date (08.05.2017)
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Journal Metrics for this   Drug Invention Today (Source ID: 21100202909): 2014 (SNIP) Source Normalized Impact Per Paper : 0.402; SCImago Journal Rank (SJR):0.301; Impact Per Publication : 0.517 (Top level : Life Science)
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Manuscripts Published

Journal: Drug Invention Today , Volume: 5, Issue: January
Article Id: JPRS-D(DD)-0000896
Title: Antibacterial study of silver doped zinc oxide nanoparticles against Staphylococcus aureus and Bacillus subtilis
Category: Drug (Discovery/Development)
Section: Research Article
Country: India
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Objectives

The present study has been undertaken to synthesize silver doped zinc oxide nanoparticles, with pharmaceutical importance. The synthesized particles have been evaluated to study the effect of silver doping on grain size and further on antibacterial activities against the microorganismsBacillus subtilis and Staphylococcus aureus.

Methods

Silver doped zinc oxide nanoparticles were prepared by the solution route spin-coating process, using zinc acetate (Zn(CH3COO)2.2H2O) and silver nitrate (AgNO3) as host and dopant precursors respectively. The antibacterial activity of the silver doped zinc oxide were studied against S. auerus and B. subtilis via using agar well diffusion method.

Results & discussion

: The structure of the powder samples was analyzed by X-ray diffraction (XRD). The effect of silver doping on grain size and further on antibacterial activity against the microorganisms B. subtilis and S. auerus is discussed.

Conclusion

It was clear from X-ray investigations that its structure is wurtzite type and that an increase in Ag-doping resulted in decrease in the grain size of the ZnO nanoparticles. Antimicrobial study against the microorganisms B. subtilis and S. auerus shows that in case of S. auerus the MIC varies with increase in Ag content but in case of B. subtilis the MIC remained constant for all concentration of Ag.

Journal: Drug Invention Today , Volume: 5, Issue: January
Article Id: JPRS-DFA-0000894
Title: Spectrophotometric determination and thermodynamic studies of the charge transfer complexes of bambuteroleHCl
Category: Drug or Formulation Analysis
Section: Research Article
Country: India
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Objective

The aim of the present work was to develop simple spectrophotometric methods for the simultaneous determination of bambuterol hydrochloride.

Method

Spectrophotometric method for determination of bambuterol hydrochloride after its conversion to bambuterol base by formation of charge transfer complexes as n-donor with π-acceptors, dichlorodicyanobenzoquinone (DDQ) and tetracyanobenzoquinodimethane (TCNQ) which were prepared in acetonitrile. They yield radical anions measured at 461 and 842 nm within concentration ranges of 36.7–183.7, 4.59–36.7 μg ml−1 with a good correlation coefficients (r2 = 0.9999–0.9998) respectively. The nature of the formed complexes was studied via determination of the association constant and the molar absorptivity using Bensi–Hildebrand equation. The free energy change (ΔG) and the enthalpy of formation (ΔH) as well as the entropy (ΔS) were determined for the reaction product with TCNQ. The method was successfully applied for the analysis of bambuterol hydrochloride in its pharmaceutical preparation where no interference could be observed from the additives commonly present as proven by good mean recoveries of 99.74% and 100.014%. There was no significant difference observed when the method was statistically compared with the pharmacopeial official method used for determination.

Conclusion

The proposed charge transfer complexation methods are rapid and simple and from the economical point of view, the analytical reagents used are inexpensive, have excellent shelf life and are available in any analytical laboratory. The suggested methods could be successfully applied for quality control and routine analysis.

Journal: Drug Invention Today , Volume: 5, Issue: January
Article Id: JPRS-D(DD)-0000895
Title: In vivo study of clobetasol propionate loaded nanoemulsion for topical application in psoriasis and atopic dermatitis
Category: Drug (Discovery/Development)
Section: Editorial
Country: India
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Objectives

Optimized formulations were subjected to various In vivo studies like anti-inflammatory activity, Nickel induced dermatitis and irritation study. Clobetasol propionate (CP) has anti-inflammatory, immunomodulatory, and antiproliferative activity. The aim of the present work was to test the hypothesis that the addition CP in nanoemulsions would result in enhancement CP delivery and leading to better antipsoriatic activity.

Materials and methods

Nanoemulsions were prepared by aqueous phase titration method, using eucalyptus oil, Tween 20, ethanol, and distilled water as the oil phase, surfactant, co-surfactant and aqueous phase, respectively.

Results and discussion

We developed a topical O/W nanoemulsion in which drug is incorporated in disperse phase of oil and evaluated its efficacy against different types ofin vivo studies. It was also found that the significantly increased their anti-inflammatory activity. It was reported that CP-loaded nanoemulsion significantly increased NTPDase (Nucleoside triphosphate diphosphohydrolases) activity in lymphocytes. This membrane protein is responsible for the hydrolysis of extracellular ATP (Adenosine triphosphate) which is responsible for cell proliferation, differentiation and inflammatory processes.In vivo irritation studies did not show any irritation in spite of having high amount of surfactant.

Conclusion

On the basis of above in vivo study we conclude that developed nanoemulsion is safe for human use because it has good anti-inflammatory action and did not show any irritation to the skin. All though nanoemulsion contain high amount of surfactant in comparison to cream.