Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . 
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.897 as on date (08.05.2017)
  Scopus Indexed ( link http://www.scimagojr.com/journalsearch.php?q=21100202909&tip=sid&clean=0)
Journal Metrics for this   Drug Invention Today (Source ID: 21100202909): 2014 (SNIP) Source Normalized Impact Per Paper : 0.402; SCImago Journal Rank (SJR):0.301; Impact Per Publication : 0.517 (Top level : Life Science)
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Manuscripts Published

Journal: Drug Invention Today , Volume: 9, Issue: 2.
Article Id: JPRS-D(DD)-00001826
Title: Validation of water system: A review
Category: Drug (Discovery/Development)
Section: Review Article
Country: India
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Water is essential for industrial, pharmaceutical, and hospital purposes, in the preparation and processing of medicines and other health products and for cleaning and hygiene purposes. A supply of clean water is an essential requirement for the establishment and maintenance of diverse human activities. Water resources provide valuable food through aquatic life and irrigation for agriculture production. Steps involved in the validation of the pharmaceutical water system are; design qualification, installation qualification, operational qualification, and performance qualification. Validation of the water system should be performed time to time so as to prove its reliability and robustness of the system for producing water of specified quality with a high degree of assurance and every report should be documented for better work. This review is an attempt to discuss about the various aspects of validation of water system.

Journal: Drug Invention Today , Volume: 9, Issue: 2.
Article Id: JPRS-PS-00001827
Title: In vivo antiplasmodial evaluation of syzygium jambos L. Alston by four day suppressive test
Category: Pharmacological Screening
Section: Research Article
Country: India
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Objective: The unexplored region of Western Ghats possesses natural source of noble therapeutic floras for many diseases. The present study was aimed to investigate the in vivo antiplasmodial activity of Syzygium jambos from Western Ghats. Methods: The four extracts acetone, chloroform, methanol and aqueous were explore their antiplasmodial activity by Peter’s four day test. Results: In Peter’s four day test significant parasite suppression 99.24% (P<0.001) was observed in Chloroquine (CQ 25mg/kg b.wg.) group prolonging the mean survival time of animals ≥30 days, whereas no average parasitaemia suppression (44.33±0.94) was observed in the negative control group. An effective parasite suppression (P<0.01) of 72.93% and 72.18% was identified in methanol and acetone extracts respectively at 600 mg/kg b.wt. The acetone and methanol extracts prolonged the mean survival days of mice groups up to 27.8 ± 0.68 and 26.0 ± 1.29 days respectively. Conclusion: Among the four extracts tested methanol and acetone extracts exhibited antimalarial activity. The present study report establishes, Syzygium jambos leaf extracts were effective with an assorted range of antiplasmodial activity and could be a potential source in the discovery of antimalarial drug.

Journal: Drug Invention Today , Volume: 9, Issue: 2.
Article Id: JPRS-PS-00001828
Title: Infusion of adrenomedullin22-52 antagonist causes uteroimplantation growth restriction during early gestation in rats
Category: Pharmacological Screening
Section: Research Article
Country: India
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Background: The present study exploited whether antagonism of endogenous Adrenomedullin (ADM) in rats during early gestation period resulted in diminished uterus and implantation growth and explored whether this causes through induction of apoptosis. Rats on gestational day 2 were implanted subcutaneously with osmotic (ALZET) minipumps delivering 125 and 250 µg/rat/day/of ADM22-52 and were killed on gestational day 9. On gestational day 9, both in the control group rats and ADM antagonist-treated rats, 5-bromo 2´deoxyuridine labeling dye is injected in the tails of rats with a concentration of 1 ml/100 g body weight and then sacrificed the animal. We have demonstrated that the uterus growth and implantation development are seriously compromised by this modest decrease in expression and the implanted sites were shown prominently by blue-/purple-colored spots both in control and ADM-treated groups. Results: Apoptotic variations were more evident in stromal trophoblastic cells in the uteroimplantation sites of ADM22-52-treated rats when compared with vehicle control rats. Immunoreactivity to active caspase-3, Bax, Bcl2 protein was abundant in the uteroimplantation regions of the ADM22-52-treated group. Conclusion: These findings, however, show that antagonism of ADM in rats during early pregnancy caused uteroimplantation growth restriction and increased fetal resorption through the activation of mitochondrial apoptotic pathways.

Journal: Drug Invention Today , Volume: 9, Issue: 2.
Article Id: JPRS-PS-00001830
Title: Evaluation of combined wound healing activity of ethanolic extracts of leaves of Murraya koenigii and Nyctanthes arbortristis on rats
Category: Pharmacological Screening
Section: Research Article
Country: India
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Objective: The present work was executed to evaluate the wound healing potency of a combined preparation of two plant extracts. The objective of this study is to induce experimental wounds using excision and incision wound model in normal albino wistar rats and to study the wound healing activity of prepared combined formulation by comparison of changes in wound healing between experimental and placebo controlled rats. Methods: The individual ethanolic extract of Murraya koenigii and Nyctanthus arbortrstis was investigated for preliminary phytochemical study. Then the effect of combined ointment formulation containing equal quantity of ethanolic extracts of leaves of Murraya koenigii and Nyctanthus arbortrstis was investigated by using excision and incision wound model in rats. Results: Both the extracts show presence of phytochemicals responsible for wound healing activity. The herbal ointment formulation 3 was found to be significantly reducing wound area, epithelization period and wound contraction rate. Similarly this formulation also shows significant increase in wound breaking strength. Conclusions: The study shows capability of both the extracts to promote accelerated wound healing activity by dose dependant manner when compared with placebo control.