Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . 
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.897 as on date (08.05.2017)
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Journal Metrics for this   Drug Invention Today (Source ID: 21100202909): 2014 (SNIP) Source Normalized Impact Per Paper : 0.402; SCImago Journal Rank (SJR):0.301; Impact Per Publication : 0.517 (Top level : Life Science)
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Manuscripts Published

Journal: Drug Invention Today , Volume: 9, Issue: 3.
Article Id: JPRS-PS-00001892
Title: Comparison of open and closed biopsies in the diagnosis of breast lumps
Category: Pharmacological Screening
Section: Research Article
Country: India
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Introduction: The breast cancer diagnosis and treatment is based on a less invasive, more accurate and effective strategybut the key factor in respect of these new standards is to confirm cancer before going to the operating room. Closedbiopsies by means of Tru-cut biopsy needle have replaced the more traditional incisional or excisional biopsies for the diagnosis of palpable breast lumps and have a definite role in the histological diagnosis of majority of palpable breastlumps. These biopsies can be performed under local anesthesia in the office or in outpatient setup. The technique is reliable,simple, and reproducible, and inexpensive; it can be adapted even for low-income developing countries. Objective:This study is designed mainly to compare the diagnostic accuracy of Tru-cut needle biopsy with that of excision biopsy.Materials and Methods: The original study is carried from July to December 2014 in Surgical Unit-1, Baqai Medical University Hospital Karachi, Pakistan. Among women with palpable breast lumps came to the outpatient, 140 patientsselected and Tru-cut needle biopsy along with excision biopsy was performed and the result of both the modalities recorded
and compared with each other. Results: The diagnosis given by Tru-cut needle biopsy is confirmed by means of excision biopsies. Therefore, it may be said that out of 49 malignant lumps 45 (91.83%) and out of 91 benign lumps 87 (95.60%)are correctly diagnosed with a total of 132 (94.28%) correct diagnosis. Conclusion: As the diagnostic accuracy of closed biopsies is considerable and very close to that of excision biopsies, the closed biopsies can be performed routinely on anoutpatient basis on women with palpable breast lumps.

Journal: Drug Invention Today , Volume: 9, Issue: 3.
Article Id: JPRS-CPS-00001935
Title: A review on antimicrobial activities of important thiazines based heterocycles
Category: Chemistry and Parallel Synthesis
Section: Review Article
Country: India
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Nowadays, a number of thiazine-based heterocycles were prepared or extracted from natural sources such as plants and animals, using various approaches and examined for their biologically important activities such as antibacterial, antifungal, anti-inflammatory, and antihypertensive to apply them as a possible pharmacological and chemical agents in a range of medicinal fields. Although several dynamic antimicrobial agents have since been developed, a allocated co-occurrence through the employ of current drugs as a single agent has developed drug resistance. This has made use to investigate for novel thiazine derivatives for ruling more effective antimicrobial agents. Thus, the present review was designed to provide a sequence of work going on the development of potential antimicrobial agents.

Journal: Drug Invention Today , Volume: 9, Issue: 3.
Article Id: JPRS-PS-00001936
Title: The influence of sleep disorders on cognitive functions of a brain at patients with Type 2 diabetes
Category: Pharmacological Screening
Section: Research Article
Country: India
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Aim: The results of neuropsychological and sleep examination with the use of validated tests and questionnaires at 136 patients with the verified Type 2 diabetes mellitus diagnosis are presented in this article. The average age of the examined patients was 59.19± 5.649. The patients were in decompensated condition on indicators of carbohydrate metabolism. Materials and Methods: A totalof 136 patients older than 40 years with clinically and laboratory proved Type 2 diabetes were examined. The research included the participants of both genders living in Astana with a different national and ethnic origin to be convinced that the research advantage and burden are distributed evenly. Results and Discussion: By results of neuropsychological testing, cognitive functions of a brainwere reduced in all age groups at patients with Type 2 diabetes and were characterized by retardation of intellectual activity rate, the reduction of speech fluency, the depression of concentration of attention, memory disturbances of dynamic character. 77.9% of patients had sleep disorders, including, mild degree - 28% of patients; moderate - 30.9% of patients. Conclusion: The intrasomnic disorders including frequent night awakenings with the subsequent difficulty of sleep initiation prevailed. It is revealed that insomnia negatively influences on such cognitive functions of a brain as attention and visual-constructive skills.

Journal: Drug Invention Today , Volume: 9, Issue: 3.
Article Id: JPRS-PS-00001937
Title: Morphological characteristics of the rats brain under hypergravity
Category: Pharmacological Screening
Section: Research Article
Country: India
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Aim: The objective of the research was to study the morphological changes in the most sensitive areas of the brain under hypergravity, using standard general histological and histochemical, as well as immunohistochemical methods with antibodies to glial fibrillary acid protein, neurofilament protein, Ki67 proliferation markers, and p53 apoptosis. Materials and Methods: The experiment was performed on 40 white Wistar rats divided into 4 groups: 1st - control, 2nd - rats exposed to hypergravity for 8 min at a centrifuge rotation rate of 5,000 rpm, 3rd - rats exposed to hypergravity 3 times during the 1st day for 5 min and at a rotation rate of 4,000 rpm, and 4th - rats exposed to hypergravity 3 times for 5 min and a rotation speed of 4,000 rpm for 3 days.After the end of the experiment, morphological changes in the brain were examined. Results: It was established that the animals of the first
group died from compression and dislocation of the brain resulted from overloads. Rats from the second group had clinical signs, such as weakness, one- and two-sided paresis, which completely passed within an hour. The histological picture of the brain had no specific features. In the third and fourth groups, the clinical symptoms were more pronounced, remaining until the end of the 1st day. Morphological picture of the immunohistochemical examination had no features but showed severe microcirculation disorders when stained with hematoxylin and eosin. Conclusion: Thus, the hypergravitational model of cerebral ischemia allows
obtaining circulatory hypoxia of the brain, which is confirmed by clinical data and general histological methods.

Journal: Drug Invention Today , Volume: 9, Issue: 3.
Article Id: JPRS-PS-00001938
Title: Minimally invasive access for open heart surgery - Relevance for modern cardiac surgical practice
Category: Pharmacological Screening
Section: Research Article
Country: India
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Today in the modern medicine, the quality of life takes on great importance, what determined significantly by the cosmetic effect of the surgery. Together with it, the variety of combinations of types of the constitution and the options of heart diseases requires the surgeon’s ability to possess different variants of mini approaches. Minimally invasive access without sternotomy was considered as the main method which reduces the duration of hospital stay after surgery; early activation of the patient and the rapid recovery of physical functions. There should be noted that the minimally invasive open-heart surgery using thoracoscopic equipment with cardiopulmonary bypass demonstrates that is a feasible method that can be performed safely and effectively, especially in the hands of experienced surgeons.

Journal: Drug Invention Today , Volume: 9, Issue: 3.
Article Id: JPRS-PS-00001939
Title: Cardiac mechanisms of chronic heart failure development in patients with ischemic heart disease, postman arcticcardiosclerosis of the elderly
Category: Pharmacological Screening
Section: Research Article
Country: India
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Aim: The objective of this study was to study the formation of myocardial remodeling in elderly patients with CHF of ischemic genesis. Materials and Methods: The object of our study was 140 elderly men suffering from CHF with a history of myocardial infarction more than 4 months ago; the average age of the examined persons was 68.4 ± 7.8 years. Results: It was determined that hypertrophic remodeling develops in most elderly patients with IHD, postinfarction cardiosclerosis, and a smaller number of patients have dilated myocardial remodeling. Thus, the morphometric study of myocardial tissue
in patients with eccentric hypertrophy of the LV revealed a significant reduction in the size of the cardiomyocyte nuclei (94.08 ± 16.41, P = 0.0057) in comparison with patients with concentric hypertrophy with a group without signs of remodeling and control group. Conclusion: It was established that structural changes occur in the formation of postinfarction cardiosclerosis. Morphological studies revealed an increase in size and a decrease in the number of myocytes and an increase in the connective tissue matrix. The density of the myocardium increases accompanied by a diastolic LV disturbance.

Journal: Drug Invention Today , Volume: 9, Issue: 3.
Article Id: JPRS-Other-00001940
Title: Mathematical modeling of the in-stent restenosis risk of patients with coronary heart disease
Category: Others ( DIT Related Science )
Section: Research Article
Country: India
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Aims: This article presents the mathematical modeling of the in-stent restenosis risk of patients with coronary heart disease, which is also known as ischemic heart disease. Methods: The mathematical model was developed based on an artificial neural network and regression analysis. Results: The results identified increased in-stent restenosis risk in patients with the following genotypes: [Hp 1-2; Gc 1-2; Tf CB; C’s SS], [Hp 2-2; Gc 1-1; Tf CC; C’s FF], [Hp 2-2; Gc 1-2; Tf CB; C’s SS], [Hp 2-2; Gc 1-1; Tf CC; C’s SS]. Conclusion: The coefficients of determination of ANN (0.21) and linear regression (0.11) were calculated. The resulting values of the coefficient of determination were <0.5, suggesting that the simulation was unacceptable. Analysis revealed that the presence or absence of restenosis was possible with the same set of phenotypes

Journal: Drug Invention Today , Volume: 9, Issue: 3.
Article Id: JPRS-D(DD)-00001948
Title: Reverse engineering ancient cu based drugs, their synthesizing methods and evolution using Vedic mind tools
Category: Drug (Discovery/Development)
Section: Research Article
Country: India
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These days reverse engineering has gathered much attention due to its diversified applications. It is a unique approach involving an entirely afresh perception of a product as a combination of parts and structure. This concept can be felt back to Plato, Vedic Maths inventive principles and even up to modern TRIZ methodology of problem-solving. Reverse engineering sometimes called back engineering extracts valuable design information or knowledge from anything human-made and reportrait same thing or anything based on the extracted information. It involves, and its applications often involved are mechanical components, electronic, computer devices, programs, biological, and chemical and biological matter. The applications it serves are broad, and its objectives are priceless, however, only a few researchers have worked on its innate concepts and applied it in the field of traditional drugs. The present work aims at reverse engineering ancient Cu based Indian drugs using Vedic inventive and alchemical mind tools. The novelty of work is using aforementioned tools in exploring what Carse calls “Anomalies you cannot account for by any of the laws known to you.” Regarding which several modern tools such as scanning electron microscopy, thermo gravimetric analysis, in vitro, and ex vivo analysis were also involved to carry the drug evolution forward in an innovative way.

Journal: Drug Invention Today , Volume: 9, Issue: 3.
Article Id: JPRS-CPS-00001949
Title: A review: Different approach of bioactive pyrimidobenzothiazoles synthesis
Category: Chemistry and Parallel Synthesis
Section: Review Article
Country: India
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Due to structural specificity, heterocyclic compounds such as pyrimidobenzothiazoles are unique with biological activities and can be utilize as potential pharmaceutical material. Pyrimidobenzothiazoles are well-known agents for different activities such as antihypertensive anti-inflammatory, analgesic, antitumor, antiviral, antihypotensive, antimalarial, antimicrobial, and anticancer, make them more leader in their class. At present, benzothiazoles and their derivatives attracted the scientific community. The present work is a review of the newest work carried out by researchers in the finding and synthesis of new biological active pyrimidobenzothiazoles.