Inter. J. of Chemical and Analytical Science
ISSN NO: 0976-1209
International Journal of Chemical and Analytical Science (IJCAS) is a international journal which publishes high quality original research articles, reviews, short communications, and case reports that contribute significantly to the advancement of the scientific knowledge in the following categories:
  • PHARMACEUTICAL CHEMISTRY:
    • Synthesis and biological studies.
    • QSAR.
    • Novel drug design.
    • Rational drug design combinatorial and parallel synthesis.
    • Estimation of drug.
    • Method developments.
    • Analysis of various pharmaceutical drugs.
    PHARMACEUTICAL ANALYSIS:
    • Medicinal chemistry
    • Organic and synthetic chemistry
    • Natural products chemistry
It's online copy circulated to all bonafide members of JPR Solutions. The Editorial Board of IJCAS comprises of eminent scientists and pharmacists from reputed institutions worldwide.
Impact Factor TM ( India ) = 0.911 as on date (12.05.2017)

Manuscripts Published

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 10.
Article Id: JPRS-AC-0000392
Title: Hydrotropic Solubilizing Agent Dimethyl Urea In Spectrophotometric Estimation of Gatifloxacin
Category: Analytical Chemistry
Section: Research Article
Country: India
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In the present investigation, hydrotropic solubilization technique has been employed to solubilize the poorly water-soluble fluoroquinolone antibiotic gatifIoxacin. There was more than 15-fold enhancement in aqueous solubility of gatifloxacin in 7.5M N,N dimethyl urea as compared to aqueous solubility. The selected λmax for spectrophotometric estimation was 288 nm. The hydrotropic agent and the additive used in the manufacture of tablet did not interfere in the analysis. Statistical data proved the accuracy, reproducibility and precision of proposed method.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 10.
Article Id: JPRS-AC-0000389
Title: Analytical Method Development and Validation of Ganciclovir API by High Performance Liquid Chromatography
Category: Analytical Chemistry
Section: Research Article
Country: India
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A rapid, sensitive and cost effective high performance liquid chromatographic method has been developed and validated for the determination of Ganciclovir in bulk. Ganciclovir was eluted on a pre-packed Phenomenex C-18 (250 × 4.6 mm, 5 μm) column with acetonitrile & 10 mM potassium dihydrogen orthophosphate buffer (pH 5.0 ± 0.05; 5: 95, v/v) as mobile phase at a flow rate of 1.0 ml/min. The detection was carried out at 252 nm. The method is linear with correlation of coefficient greater than 0.998. Percentage RSD of precision study was observed 0.289. The method was rugged showing the percentage RSD of 0.671 and 0.651 for intra-day and inter-day respectively. The method is applicable for the assay of Ganciclovir determination in bulk drug.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 10.
Article Id: JPRS-SDS-0000390
Title: Synthesis and antifungal study of novel fluoro-benzothiazole derivatives
Category: Synthetic Drug Study
Section: Research Article
Country: India
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N-{6-fluoro-7-[(substituted)-amino] 1, 3-benzothiazole-2-yl}-2-nitrobenzamides; N-{6-fluoro-7-[(substituted)-amino] 1, 3-benzothiazole-2-yl}-3-nitrobenzamides and N-{6-fluoro-7-[(substituted)-amino] 1, 3-benzothiazole-2-yl}-4-nitrobenzamides derivatives were synthesized. The synthesized compounds were screened for antifungal activity at two different concentrations (50μg/ml, 100μg/ml) against Candida albicans and Aspergillus niger by cup plate method (diffusion technique) using Griseoflavin as standard.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 10.
Article Id: JPRS-AC-0000391
Title: Spectro-Photometric Determination of Capecitabine In Pharmaceutical formulations
Category: Analytical Chemistry
Section: Research Article
Country: India
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Rapid, simple and sensitive spectrophotometric methods are presented for the determination of Capecitabine. The methods are based on their oxidation and precipitation reactions. In both methods the reactions can be monitored spectrophotometrically by measuring the absorbance of the produced complexes at 520 and 560 nm. The proposed methods have permitted the quantification of Capecitabine over linearity in the range of 10-120 mg/ml and its percentage recovery was found to be 99.65-99.93 %.