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Inter. J. of Chemical and Analytical Science
ISSN NO: 0976-1209
International Journal of Chemical and Analytical Science (IJCAS) is a international journal which publishes high quality original research articles, reviews, short communications, and case reports that contribute significantly to the advancement of the scientific knowledge in the following categories:
    • Synthesis and biological studies.
    • QSAR.
    • Novel drug design.
    • Rational drug design combinatorial and parallel synthesis.
    • Estimation of drug.
    • Method developments.
    • Analysis of various pharmaceutical drugs.
    • Medicinal chemistry
    • Organic and synthetic chemistry
    • Natural products chemistry
It's online copy circulated to all bonafide members of JPR Solutions. The Editorial Board of IJCAS comprises of eminent scientists and pharmacists from reputed institutions worldwide.
Impact Factor TM ( India ) = 0.918 as on date (12.03.2018)

Manuscripts Published

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: February
Article Id: JPRS-AC-0000321
Title: Physicochemical characterization, formulation, and dissolution studies of ezetimibe hydroxypropyl ß -cyclodextrin inclusion complex.
Category: Analytical Chemistry
Section: Research Article
Author Affiliation: Sinhgad Institute of Pharmaceutical Sciences, S. No. 809/810, off Mumbai-Pune Expressway,Kusgaon (Bk.), Lonavala Dist. Pune. 410 401Maharashtra, India.
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The objective of this research was to prepare, characterize and to study effect on dissolution of inclusion complexes of Ezetimibe (EZM), with hydroxypropyl- ß- cyclodextrin (HPß-CD). Phase solubility curve was of A L type, indicating the 1:1 stoichimetry for HP-ß-CD: EZM complexation. The complexes were prepared by methods such as kneading, co-evaporation and physical mixing. The EZM in all samples were characterized by FTIR spectroscopy, DSC and PXRD studies. The highest improvement indissolution of EZM was observed in complex prepared using co-evaporation method and were assessed by mean dissolution time (MDT) and similarity factor f2.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: February
Article Id: JPRS-AC-0000322
Title: Method development and validation of RP-HPLC method for simultaneous determination of ibuprofen and methocarbamol
Category: Analytical Chemistry
Section: Research Article
Author Affiliation: Department of Pharmaceutical Analysis, Vinayaka Mission’s College of Pharmacy,Vinayaka Missions University, Salem-636008, Tamilnadu.
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A rapid, sensitive and specific RP-HPLC method involving UV detection was developed and validated for determination and quantification of Ibuprofen and Methocarbamol. Chromatography was carried out on a pre-packed Develosil, ODS-MG-5 (150*4.6mm, 5μ column using filtered and degassed mixture of chloroacetic acid buffer and acetonitrile in the ratio of (400:600) as mobile phase at a flow rate of 1.0ml/min and effluent was monitored at 230nm. The method was validated in terms of linearity, precision, accuracy, and specificity, limit of quantification and limit of detection. The assay was linear over the concentration range of Ibuprofen and Methocarbamol was 20mcg-60mcg/ml and 500mcg to 1500mcg/ml respectively. Accuracy of the method was determined through recovery studies by adding known quantities of standard drug to the pre analyzed test solution and was found to be 99.7%-100.06% and 99.90%-100.01% within precision RSD of 0.05 and 0.94 for Ibuprofen and Methocarbamol respectively. The system suitability parameters such as theoretical plates and tailing factor were found to be 9610.4, 1.2 and 4611.8, 1.1 respectively for Ibuprofen and Methocarbamol. The method does require only 10 minutes as run time for analysis which prove the adoptability of the method for the routine quality control of the drug.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: February
Article Id: JPRS-AC-0000323
Title: Comparative study on identification and estimation of Methionine in the pharmaceutical dosage forms
Category: Analytical Chemistry
Section: Research Article
Author Affiliation: Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Nalgonda (D) – 508284
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Aim: Identification and estimation of methionine in pharmaceutical Dosage forms by different Analytical methods. Methods :A novel method for the identification and estimation of DL-Methionine in various pharmaceutical dosage forms like tablets and syrups was developed. Identification was done by the Paper chromatography technique; identification carried out by measuring color development by ninhydrin as a spray reagent. The absorbance of the solution was measured at 570 nm. Beer-Lambert’s law was observed to obey in the range of 10-100 mcg. In the estimation of methionine in pharmaceutical dosage forms, the quadratic polynomial coefficient was computed by measuring the fluorescence of the drug in 0.01N hydrochloric acid and six points equally spaced at 5nm levels on the emission spectrum from 550 to 575 nm were plotted. The quadratic polynomial coefficient was found to be linear (directly proportional) to the concentration in the range 0.5 to 2.0mcg. Results: Recoveries were quantitative with good reproducibility. Excipients like bronidiol, parabens, essences, sugars and coloring agents did not interfere with proposed methods, Method A. (Beer-Lamberts Law ) both the isomers of Methionine D AND L forms gave Rf values of 0.32 and 0.40 respectively. The linear responses were in the range of 10-100mcg. The experimental recovery was 98-99% with 99-100% reproducibility.Method B: Paracetamol and Ibuprofen did not interfere with the proposed method. Estimation of Methionine by method B (orthogonal polynomials) was although linear but comparatively less precise with recoveries of 97-99% with 99% reproducibility. Conclusion: The above findings suggest that the estimation of the compound could be done by either of the methods with a good correlation between them within the specified limits of concentration. How ever comparatively Beer-Lamberts Law is found to be much more precise than the other. Thus, the analysis of compound by orthogonal polynomial coefficient although is an important and convenient tool, but less effective in comparison to other method (beer lamberts law).

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: February
Article Id: JPRS-AC-0000324
Title: RP-HPLC method development for the determination of assay of Donepezil hydrochloride
Category: Analytical Chemistry
Section: Research Article
Author Affiliation: Department of Chemistry, Sri Krishnadevaraya University, Anathapur-515003, A.P. India
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RP-HPLC method was developed and validated by assessing linearity, accuracy, selectivity, limit of quantitation, and precision for the determination of Donepezil hydrochloride. Donepezil was identified and quantitated on a C18 reversed phase column (3.9×150mm, 5.0μm), using a mobile phase composed of acetate buffer-Acetonitrile (50:50v/v) delivered at a flow rate of 1.0mL/min, and with UV detection (λexcitation = 230nm). The method was proven to be linear over a Donepezil hydrochloride concentration range of 12.5 to 75μg/mL with a mean correlation coefficient of 0.9999.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: February
Article Id: JPRS-Es-0000325
Title: Advances in biochemical functions and the photochemistry of flavins and flavoproteins
Category: Enzyme study
Section: Review Article
Author Affiliation: Institute of Pharmaceutical Sciences, Baqai Medical University, Toll Plaza, Super Highway, Gadap Road, Karachi-74600, Pakistan
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The biochemical and photochemical aspects of flavins and flavoproteins have been reviewed with particular reference to their biochemical functions, nutritional importance and photochemical reactions including photodegradation, photosensitization and photoreception. The flavin coenzymes are involved in a wide variety of metabolic reactions. The two main photochemical reactions of flavins have been described as intramolecular photoreduction and intramolecular photoaddition leading to the formation of lumichrome and cyclodehydroriboflavin, respectively, as the major final products. Flavin-sensitized photochemical reactions have important biological implications. The techniques of laser flash photolysis, femtosecond-resolved fluorescence spectroscopy and transient absorption spectroscopy have been applied to study the dynamics of flavoproteins. Information regarding the photostability of riboflavin (vitamin B2) in pharmaceutical preparations has been provided.