Inter. J. of Chemical and Analytical Science
ISSN NO: 0976-1209
International Journal of Chemical and Analytical Science (IJCAS) is a international journal which publishes high quality original research articles, reviews, short communications, and case reports that contribute significantly to the advancement of the scientific knowledge in the following categories:
  • PHARMACEUTICAL CHEMISTRY:
    • Synthesis and biological studies.
    • QSAR.
    • Novel drug design.
    • Rational drug design combinatorial and parallel synthesis.
    • Estimation of drug.
    • Method developments.
    • Analysis of various pharmaceutical drugs.
    PHARMACEUTICAL ANALYSIS:
    • Medicinal chemistry
    • Organic and synthetic chemistry
    • Natural products chemistry
It's online copy circulated to all bonafide members of JPR Solutions. The Editorial Board of IJCAS comprises of eminent scientists and pharmacists from reputed institutions worldwide.
Impact Factor TM ( India ) = 0.918 as on date (12.03.2018)

Manuscripts Published

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: April
Article Id: JPRS-AC-0000338
Title: New Spectrophotometric method to determine Ketoprofen in tablet dosage form using mixed Hydrotropy
Category: Analytical Chemistry
Section: Research Article
Country: India
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In this investigation, a blend consisting of 30% urea and 30% sodium citrate solution has been used as hydrotropic solubilizing agent for ketoprofen to carry out its spectrophotometric analysis. Ketoprofen shows tremendous increase in aqueous solubility of more than 700 folds in this blend. Thus, it was thought worthwhile to solubilize ketoprofen by this blend of solubilizing agents to carry out spectrophotometric analysis. Ketoprofen showed maximum absorbance at 260 nm and Beer’s law was obeyed in concentration range of 4-20 μg/ml. The mean percent label claims estimated were very close to 100 with low values of standard deviation, percent coefficient of variation and standard error indicating the accuracy of the proposed analytical method. The results of recovery studies showed that the mean percent recoveries ranged from 99.49 to 101.37, which further proved the validity and reproducibility of the proposed method. Thus, it may be concluded that the proposed method of analysis is new, simple, cost-effective, environmentally friendly, safe, accurate, and reproducible.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: April
Article Id: JPRS-AC-0000339
Title: Photodegradation and Photostabilization of Ascorbic Acid in Pharmaceutical Preparations
Category: Analytical Chemistry
Section: Research Article
Country: India
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A number of drug substances and their formulated products including ascorbic acid may degrade on exposure to light and appropriate precautions are to be taken to preserve the active ingredients as raw material and in dosage forms. Ascorbic acid solutions on UV irradiation are degraded to dehydroascorbic acid and further photoproducts including 2,3-diketo-L-gulonic acid, oxalic acid and L-theoronic acid. Pharmaceutical formulations containing ascorbic acid have been stabilized by using antioxidants, DL-methionine, mannitol, sorbitol, sucrose, dextrose, halide salts, triplet quenchers, metal-complexing agents and viscosity enhancing agents.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: April
Article Id: JPRS-PSPA-0000340
Title: Evaluation of Antibacterial Activity of Lepidium sativum Linn. Seeds against Food-borne Pathogens
Category: Phytochemical Study and Pharmacological Activity
Section: Research Article
Country: India
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constituents of the dried powdered seeds were extracted using solvents viz., chloroform, ethyl acetate, methanol, and dichloromethane. The antibacterial activities of the concentrated extracts were evaluated by agar well diffusion method. The methanol extract showed the effective antibacterial activity against the pathogens used in this study. The minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC) were also determined for most active extract by tube dilution method and subculturing method respectively. The MIC values of the methanol extract ranged from 1.56 mg/ml to 25.0 mg/ml whereas the MBC values ranged from 6.25 mg/ml to 25.0 mg/ml. These results suggest the potential use of the seeds of Lepidium sativum for the control of infectious diseases from food poisoning. However, more adequate toxicological study must be carried out to verify the possibility of using it for fighting pathogenic microorganisms in human.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: April
Article Id: JPRS-AC-0000341
Title: Simultaneous estimation of sumatriptan succinate and ergotamine tartrate in the tablet dosage form.
Category: Analytical Chemistry
Section: Research Article
Country: India
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A simple, specific, accurate and economical, an isocratic reversed phase liquid chromatographic (RP-HPLC) method was developed and subsequently validated for the determination of sumatriptan succinate and ergotamine tartrate. Separation was achieved with a Nucleodur C– 18 column having 250x4.6 mm i.d. with 5μm particle size and 10mmol disodium hydrogen phosphate buffer, adjusted to pH 6.5 using diluted ortho phosphoric acid and acetonitrile (50:50 v/v) with isocratic program as eluent at a constant flow rate of 1.0 ml/min. UV detection was performed at 210 nm. The retention times of sumatriptan succinate and ergotamine tartrate were about 3.79min and 8.00min respectively. This method is simple, rapid and selective and can be used for routine analysis of sumatriptan succinate and ergotamine tartrate. The proposed method shows good linearity, accuracy and reproducibility. Results of analysis validated statistically and by recovery studies.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: April
Article Id: JPRS-PC-0000342
Title: Review on Mucco Adhesive Buccal film and its Importance
Category: Pharmaceutical Chemistry
Section: Review Article
Country: India
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For many decades, treatment of an acute disease or a chronic illness has been mostly accomplished by delivering drugs using various pharmaceutical dosage forms including tablets, capsules, pills, suppositories, creams, ointments, liquids, aerosols, and injectables as carriers. . However, this route presents some problems for a few drugs. The enzymes in the GI fluids, GIT-pH conditions, and the enzymes bound to GIT membranes are a few factors responsible for the bioavailability problems. During past few years, increasing interest has arisen in the use of bioadhesive formulations for the development of novel drug delivery systems. Bioadhesive formulations have a wide scope of applications, for both systemic and local effects.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: April
Article Id: JPRS-PSPA-0000344
Title: A Review on Bergenia Ligulata Wall
Category: Phytochemical Study and Pharmacological Activity
Section: Review Article
Country: India
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Bergenia ligulata Wall (Saxifragaceae) is perennial herb that grows wild in stones and rocks. This plant has been reported to exhibit various biological activities & thus has several traditional uses. It is used as an antidiabetic, diuretic, astringent, cardiotonic, woundhealer, expectorant, antipyretic, kidneystone & as a tonic. This review presents a comprehensive literature search of different studies carried out on phytoconstituents like ß-sitosterol, ß-sitosterol-D-glucoside, afzelechin and Catechin.Further investigations may help in exploiting its properties.