Inter. J. of Chemical and Analytical Science
ISSN NO: 0976-1209
International Journal of Chemical and Analytical Science (IJCAS) is a international journal which publishes high quality original research articles, reviews, short communications, and case reports that contribute significantly to the advancement of the scientific knowledge in the following categories:
  • PHARMACEUTICAL CHEMISTRY:
    • Synthesis and biological studies.
    • QSAR.
    • Novel drug design.
    • Rational drug design combinatorial and parallel synthesis.
    • Estimation of drug.
    • Method developments.
    • Analysis of various pharmaceutical drugs.
    PHARMACEUTICAL ANALYSIS:
    • Medicinal chemistry
    • Organic and synthetic chemistry
    • Natural products chemistry
It's online copy circulated to all bonafide members of JPR Solutions. The Editorial Board of IJCAS comprises of eminent scientists and pharmacists from reputed institutions worldwide.
Impact Factor TM ( India ) = 0.918 as on date (12.03.2018)

Manuscripts Published

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 3.
Article Id: JPRS-AC-0000331
Title: Simultaneous determination of tetravalent vanadium and hexavalent molybdenum using second derivative spectrophotometry
Category: Analytical Chemistry
Section: Research Article
Country: India
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A second derivative spectrophotometric procedure is developed for the simultaneous determination of vanadium (IV) and molybdenum (VI). The method is based on the color reaction between tetracycline (TCL) and the above mentioned ions in a solution of pH 5.5. The simultaneous determination is performed by measuring the signal at zero crossing wave length. The linear calibration range, regression equation, correlation coefficient and relative error are reported in each case. The results obtained by the proposed method were in good agreement with those obtained by the standard method.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 3.
Article Id: JPRS-PSPA-0000332
Title: Evaluation of Physicochemical and Standardisation parameters of Solanum xanthocarpum Schrad. & Wendl.
Category: Phytochemical Study and Pharmacological Activity
Section: Research Article
Country: India
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The medicinal plants are widely used by the traditional medical practitioners for curing various diseases. In traditional systems of medicine, different parts like leaves, stem, flower, root, seeds and even whole plant of of plant Solanum xanthocarpum Schrad. & Wendl. (Solanaceae) are used. It is commonly known as Yellow Berried Nightshade (syn: kantakari). It is a prickly diffuse bright green perennial herb, woody at the base and 2–3 m in height. It is found throughout India mostly in dry places as a weed on roadsides and waste lands. The fruit is used as anti-asthmatic, hypoglycaemic, anti-inflammatory, antitumor, anti-tussive, antifeedant, antipyretic, antispasmodic, anti-histaminic, hypotensive, antianaphylactic and cytotoxic activity. Till today there is no detailed standardisation work reported for the Solanum xanthocarpum. Physicochemical parameters like preliminary characteristics, toxic heavy metals, pesticide residue, aflatoxin and microbial contamination analysis were carried out. The study revealed different parameters of the crude drug which will be useful in identification and control of adulterations.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 3.
Article Id: JPRS-AC-0000333
Title: Simultaneous estimation of aceclofenac, tramadol hydrochloride and paracetamol by UV spectrophotometric simultaneous equation method from tablet formulation
Category: Analytical Chemistry
Section: Research Article
Country: India
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A simple, accurate, precise and economical procedure for simultaneous estimation of aceclofenac, tramadol hydrochloride and paracetamol in three component tablet dosage form has been developed utilizing concept of internal standard addition. The method is based upon determination of aceclofenac at 275.5nm, tramadol hydrochloride at 271.0 nm and paracetamol at 247.0 nm in methanol diluted with distilled water. Aceclofenac, tramadol hydrochloride and paracetamol at their respective ëmax 275.5nm, 271.0 nm and 247.0 nm shows linearity in the concentration range of 5- 25 μg/ml, 20-100 μg/ml and 3-15 μg/ml respectively. The method was validated statistically. Recovery study was performed to confirm the accuracy of the method.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 3.
Article Id: JPRS-PSPA-0000335
Title: Diabetic Nephropathy : An Updated Review
Category: Phytochemical Study and Pharmacological Activity
Section: Review Article
Country: India
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Diabetic nephropathy is associated with increased mortality in diabetic patients and is a major cause of end stage renal disease in most countries. Diabetic nephropathy seems to occur as a result of an interaction between metabolic and haemodynamic factors .Glucose dependent pathway are activated with in diabetic kidney .These include increased oxidative stress and accumulation of advanced glycated endproduct. Haemodynamic factors are also implicated in the pathogenesis of diabetic nephropathy and include increased systemic and intraglomerular pressure and activation of various vasoactive hormone pathways including renin-angiotensin and endothelin. Despite the modern therapies involved in the management and prevention of diabetic nephropathy include antidiabetics ,anti-hypertensive, particularly those which interrupt the renin-angiotensin system, antioxidants and inhibitors of advanced glycation end product are available to treat diabetic nephropathy.The purpose of this review is to bring together the current information concerning the signaling system involved in the pathogenesis of diabetic nephropathy.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 3.
Article Id: JPRS-PSPA-0000327
Title: A Comparative study for quality assessment of Calotropis procera Linn. root at selected regions
Category: Phytochemical Study and Pharmacological Activity
Section: Research Article
Country: India
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The herbal drug Alarka is botanically called as Calotropis procera Linn. In the recent past tremendous attempts are being made to evaluate the scientific standards for traditional system of medicines, particularly in Ayurvedic system of medicine. The use of the plants, plant extracts, and pure compounds isolated from natural sources has always provided a foundation for modern pharmaceutical compounds. Calotropis procera Linn is small, erect and compact shrubs, which is used in several traditional medicines to cure various diseases. This shrub has been known to posses Analgesic, Antitumor, Antihelmintic, Antioxidant, Hepatoprotective, Inflammatory, Antidiarrhoeal, Anticonvulsant, Antimicrobial, Oestrogenic, Antinociceptive, and Antimalarial activity. A wide range of chemical compounds including- Benzoyllineolone, benzoylisolinelone and ß-amyrin. The root bark contains the calotropoleanyl ester, proceroleanenol A and proceroleanenol B. The latex contains the calactin, calotropin, uscharin, sitosterol, and calotoxin. The thin layer chromatographic studies of alcohol extract was also carried out to ascertain the quality of this drug. For the evaluation of Pharmacopoeial standards phytochemical parameters are adopted. These studies suggested that the observed physiochemical parameters are of great value in quality control and formulation development of Calotropis procera.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 3.
Article Id: JPRS-PSPA-0000326
Title: Antihyperlipidemic potential of a polyherbal drug (Geriforte) on atherogenic diet induced hyperlipidemia: A Comparison with Ayurslim
Category: Phytochemical Study and Pharmacological Activity
Section: Research Article
Country: India
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We investigated the antihyperlipidemic activity of a polyherbal drug (Geriforte). The present study was undertaken to assess body weight, total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) and very low density lipoprotein (VLDL) potential of the polyherbal drug (Geriforte) using atherogenic diet induced hyperlipidemia. The animals were divided into four groups: normal control, hyperlipidemic control, hyperlipidemic plus Geriforte and hyperlipidemic plus Ayurslim. Hyperlipidemia was induced by treated orally with butter fat (79% standard diet + 21% butter fat). Intragastric administration of Geriforte (450 mgkg-1 body weight) for 8 days significantly decreased body weight, TC, TG and LDL and VLDL whereas significantly increased level of HDL. Atherogenic index was lowered in the Geriforte drug fed animals when compared to hyperlipidemic animals. Geriforte exhibited quite competitive potential when compared with the reference drug Ayurslim affording a possible alternative therapeutic drug in the treatment of hyperlipidemia.