Inter. J. of Chemical and Analytical Science
ISSN NO: 0976-1209
International Journal of Chemical and Analytical Science (IJCAS) is a international journal which publishes high quality original research articles, reviews, short communications, and case reports that contribute significantly to the advancement of the scientific knowledge in the following categories:
  • PHARMACEUTICAL CHEMISTRY:
    • Synthesis and biological studies.
    • QSAR.
    • Novel drug design.
    • Rational drug design combinatorial and parallel synthesis.
    • Estimation of drug.
    • Method developments.
    • Analysis of various pharmaceutical drugs.
    PHARMACEUTICAL ANALYSIS:
    • Medicinal chemistry
    • Organic and synthetic chemistry
    • Natural products chemistry
It's online copy circulated to all bonafide members of JPR Solutions. The Editorial Board of IJCAS comprises of eminent scientists and pharmacists from reputed institutions worldwide.
Impact Factor TM ( India ) = 0.918 as on date (12.03.2018)

Manuscripts Published

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 5.
Article Id: JPRS-PSPA-0000345
Title: Antibacterial Efficacy of Secondary Metabolites from Entomopathogenic Fungi Beauveria bassiana
Category: Phytochemical Study and Pharmacological Activity
Section: Research Article
Country: India
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This study was performed to evaluate the antibacterial activity of crude ethyl acetate extract of the entomopathogenic fungi Beauveria bassiana (ITCC 4688) against ten aerobic pathogenic bacteria including Bacillus megaterium, Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Micrococcus luteus, Bacillus subtilis, Bacillus sphaericus, Klebsiella aerogenes, Psuedomonas aeruginosa and Chromobacterium violaceum. The acetate extracts of Beauveria bassiana (ITCC 4688) were shown to possess an inhibiting activity (MIC < or = mg/L) against many of the species tested. Significant antibacterial activity was found from 500 to 1000 μg/ml against Bacillus megaterium, Bacillus subtilis, Bacillus sphaericus, Escherichia coli; 700 to 1000 μg/ml against Micrococcus luteus, Pseudomonas aeruginosa and from 900 to 1000 μg /ml against Streptococcus pyogenes, Chromobacterium violaceum. The results suggest differential action of antibacterial property of crude extract of B. bassiana depending upon the active compounds on the specific bacteria. Hence, the present study gives an idea to test against more number of organisms and to find out the actual antibacterial compound from B. bassiana.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 5.
Article Id: JPRS-SDS-0000346
Title: Synthesis, characterization and anti-inflammatory activity of 4-(substituted phenyl)-5-(2,4- dinitrophenyl)-3-methyl-1,3a,4,5-tetrahydropyrazolo-[3,4-c] pyrazoles
Category: Synthetic Drug Study
Section: Research Article
Country: India
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Ethyl acetoacetate (I) was stirred with hydrazine hydrate in ethanol to get 5-methyl-2,4 dihydro-3H-pyrazol-3-one (II). This was refluxed with different aryl aldehydes in glacial acetic acid in presence of fused sodium acetate to get corresponding (4E)-4-(substituted benzylidene)-5-methyl-2,4–dihydro-3Hpyrazol- 3-one (IIIa-f). These were treated with 2,4-dinitro phenyl hydrazine to get a series of 4-(substituted phenyl)-5-(2,4-dinitrophenyl)-3-methyl- 1,3a,4,5-tetrahydropyrazolo-[3,4-c]pyrazole (IVa-f). The structures of the compounds have been established based on their analytical and spectral data. All the compounds have been screened for their anti-inflammatory activity.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 5.
Article Id: JPRS-PC-0000347
Title: Combinatorial chemistry and its application - a review
Category: Pharmaceutical Chemistry
Section: Review Article
Country: India
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The use of combinatorial chemistry techniques has been explored as an alternative to conventional approaches for the synthesis of compounds in the drug discovery process. This technique is the starting point for the development of synthesis concepts that were intended to cover and explore the chemical space without having to prepare every individual compound. Combinatorial Chemistry technologies were developed in response to the increased screening capacities that are available when drug discovery changed its screening paradigm from a pharmacology-based approach to target oriented lead finding. This article will illustrate technique used in combinatorial chemistry, some of the advances made in recent years and their application in the synthesis of different peptides, oligosaccharides and other molecules.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 5.
Article Id: JPRS-CE-0000348
Title: Tannin acyl hydrolase from Trichoderma viride
Category: Chemical Engineering
Section: Research Article
Country: India
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The enzyme tannase (tannin acyl hydrolase EC 3.1.1.20) produced from Trichoderma viride (MTCC 167), was purified and characterized. Optimal conditions for the production tannase were determined using varying substrate concentrations Fermentation was carried out for 48 h for optimum enzyme production and the properties of the enzyme were investigated. The optimum conditions of temperature and pH were investigated and the effects of nitrogen sources, metal ions and chelator were studied. Tannase exhibited optimum activity at 45°C and at pH of 5.5 urea concentrations higher than 3 M were inhibitory. Increasing concentrations of sodium also led to decrease in activity. Increasing concentrations of EDTA had an inhibitory effect on tannase. Among the nitrogen sources selected ammonium ferrous sulfate, ammonium sulfate, ammonium nitrate and ammonium chloride enhanced tannase activity at 0.1% (W/V) concentration.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 5.
Article Id: JPRS-SDS-0000349
Title: Pharmacological action and SAR of Phthalazine derivatives - A Review
Category: Synthetic Drug Study
Section: Review Article
Country: India
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The chemistry of phthalazine (2, 3 benzodiazine) is very well known. These systems are widely used in organic chemistry as intermediates for the synthesis of numerous compounds. On the other hand; phthalazine derivatives were extensively studied as bioactive compounds. They possess remarkable biological activity, such as anticonvulsant, antimicrobial, anti-inflammatory, antifungal, antibacterial and vasorelaxant activity among others. Recently, the research and development in the medicinal chemistry of phthalazine produced hybrid compounds in which phthalazine moiety together with classical drug moieties are present in a single molecule. So, new anticonvulsant drugs, PDE4 inhibitor and Topoisomerase II inhibitors were developed. These review paper recent developments in the medicinal chemistry of phthalazine will be reviewed.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 5.
Article Id: JPRS-GC-0000350
Title: An environment-friendly approach with green chemistry
Category: Green chemistry
Section: Review Article
Country: India
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Environmental pollution and destruction on a global scale have drawn attention to the vital need for totally new environmentally friendly, clean chemical technologies and processes, the most important challenge facing chemical scientists in the field of green chemistry. The beginning of green chemistry is frequently considered as a response to the need to reduce the damage of the environment by man-made materials and the processes used to produce them. A quick view of green chemistry issues in the past decade demonstrates many methodologies that protect human health and the environment in an economically beneficial manner. This article presents selected examples of the implementation of green chemistry principles in everyday life in industry, laboratory and in education.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 5.
Article Id: JPRS-PSPA-0000351
Title: Medicinal plants used in the healing of skin diseases in different regions of India: A Review
Category: Phytochemical Study and Pharmacological Activity
Section: Review Article
Country: India
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Various plant species are used in the treatment of skin diseases, like leprosy, scabies, rash, wound, psoriasis, swelling, eczema, dandruff. A large number of plants/plant extracts/decoctions or pastes are equally used by tribal’s and folklore traditions in India for treatment of cuts, wounds, and burns. The traditional healers are on the decline because the younger members of the tribe have started moving towards the towns and cities and are not willing to practice this form of medicine. There is danger that the knowledge of these medicinal plants will also die with them. It is therefore, necessary to document the plants and take efficient steps to conserve them. Skin health is increasingly becoming an important aspect of primary health care among many communities particularly because of the increased challenge of HIV-AIDS, skin conditions being among the common opportunistic diseases in immuno-compromised individuals. This study investigated the use of traditional remedies in managing various skin conditions by people of different Regions of India. The present review thus attempts to analyze the ethno botanical knowledge of medicinal herbs utilize for treatment of various skin diseases using by people of different Regions of India.