Inter. J. of Chemical and Analytical Science
ISSN NO: 0976-1209
International Journal of Chemical and Analytical Science (IJCAS) is a international journal which publishes high quality original research articles, reviews, short communications, and case reports that contribute significantly to the advancement of the scientific knowledge in the following categories:
  • PHARMACEUTICAL CHEMISTRY:
    • Synthesis and biological studies.
    • QSAR.
    • Novel drug design.
    • Rational drug design combinatorial and parallel synthesis.
    • Estimation of drug.
    • Method developments.
    • Analysis of various pharmaceutical drugs.
    PHARMACEUTICAL ANALYSIS:
    • Medicinal chemistry
    • Organic and synthetic chemistry
    • Natural products chemistry
It's online copy circulated to all bonafide members of JPR Solutions. The Editorial Board of IJCAS comprises of eminent scientists and pharmacists from reputed institutions worldwide.
Impact Factor TM ( India ) = 0.918 as on date (12.03.2018)

Manuscripts Published

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 6.
Article Id: JPRS-PC-0000355
Title: Synthesis and Anti-Inflammatory Activity of Some 5-Phenyl-1-(Acyl)-1, 2, 3, 4-Tetrazole.
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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A novel substituted pyrazole trifluoro methyl hexa hydro pyrimidinones (4a-g) have been prepared by Biginelli condensation of six substituted pyrazolealdehydes, ethyltrifluoroacetoacetate and urea using zinc chloride as catalyst. The structures of the synthesized compounds have been confirmed on the basis of spectral data. The newly synthesized compounds have been assayed invitro for antimicrobial activity and cardiotonic activity.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 6.
Article Id: JPRS-AC-0000356
Title: Spectrophotometric Estimation of Gemifloxacin in bulk and Pharmaceutical dosage form by UV Spectrophotometry
Category: Analytical Chemistry
Section: Research Article
Country: India
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The present study describes a simple, accurate, precise and cost effective UV-VIS Spectrophotometric method for the estimation of Gemifloxacin, a fluroquinolone derivative, in bulk and pharmaceutical dosage form. The solvent used was double distilled water and the lmax or the absorption maxima of the drug was found to be 269nm. A linear response was observed in the range of 2-10μg/ml with a regression coefficient of 0.999. The method was then validated for different parameters as per the ICH [2] (International Conference for Harmonization) guidelines. This method can be used for the determination of Gemifloxacin in quality control of formulation without interference of the excipients.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 6.
Article Id: JPRS-MD-0000352
Title: Antimicrobial activity of seaweeds Gracillaria, Padina and Sargassum sps. on clinical and phytopathogensSubba Rangaiah G, Lakshmi P* and Manjula E
Category: Marine Drugs
Section: Research Article
Country: India
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Because of the evolving resistance of microorganisms to existing antibiotics, there is an increasing need for new antibiotics. Since seaweeds offer particularly rich source of bioactive molecules, the present study was carried out to investigate the antimicrobial potentiality of the marine algae, two species of brown algae namely Sargassum ilicifolium, Padina tetrastromatica and one red algae Gracilaria corticata collected from different coastal regions. For microbiological testing of the seaweed extracts, agar well diffusion method was used. The zone of inhibition was measured for all the Different crude algal extracts (Chloroform, ethanol, methanol and water) against six strains of Gram positive, Gram negative bacterial and Fungal organisms that cause diseases and disorders in man, animals and plants.Crude extracts revealed a wide range of antimicrobial activity against tested pathogens. Seaweed extracts in different solvents exhibited different antimicrobial activities. In case of Sargassum ilicifolium, Padina tetrastromatica, of the various solvents used for seaweed extractions, maximum inhibition was noticed with ethanol extracts and minimum with chloroform crude extracts while in case of Gracilaria corticata, maximum inhibition was noticed with methanol and minimum with chloroform extracts. However, no specific solvent exhibited activity against all the test organisms effectively. Further bacterial strains were more sensitive to the extracts when compared to the fungal organisms. The overall antimicrobial activity assessed from the above results indicates the presence of active constituents in the extractions of seaweeds which can be exploited for the production of lead molecules which are of use in pharmaceutical industry.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 6.
Article Id: JPRS-AC-0000353
Title: Simultaneous Spectrophotometric Estimation of Paracetamol and Aceclofenac in Combined Tablet Formulations using Hydrotropic Solubilization Technique
Category: Analytical Chemistry
Section: Research Article
Country: India
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Quantitative estimation of poorly water-soluble drugs involves the use of organic solvents. Major drawbacks of organic solvents include high cost, toxicity, volatility and pollution. In the present investigation, the hydrotropic solubilization is employed to enhance the aqueous solubilities of poorly water-soluble drugs, paracetamol and aceclofenac in two-component tablet formulation for simultaneous spectrophotometric determination. Three simple, precise, accurate and economical procedures employed are simultaneous equation method, absorbance ratio method and multicomponent mode of analysis. All the methods utilize the combined hydrotropic blend of 20% urea solution and 20% sodium citrate solution precluding the use of organic solvent. In the mixed hydrotropic solution, paracetamol and aceclofenac shows maximum absorption at 245 nm and 274 nm, respectively and isoabsorptive point observed was 262 nm. The hydrotropic agents show no absorbance above 237 nm. The hydrotropicagents as well as tablet excipients in formulation did not interfere in the analysis. The results of analysis have been validated statistically.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 6.
Article Id: JPRS-PC-0000354
Title: Differential pulse polarographic determination of Mn(II) and Zn(II) in biological and human hair samples after preconcentration of its complex with 2, 2’-{benzene-1, 2-diylbis (nitrilomethylylidene]
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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A differential pulse polarographic method has been developed for the determination of Mn(II) and Zn(II) in biological and human hair samples using newly synthesized reagent 2,2'-{benzene-1,2-diylbis(nitrilomethylylidene]}diphenol after preconcentration and separation using amberlite XAD-1180 in the range of pH 8.0-10.0. The sorbed elements was subsequently eluted with 10mL of 2.0 M HCl elutes was analysed by differential pulse polarography (DPP). The interference of foreign ions has also been studied. Effects of various instrumental parameters are investigated and received conditions are optimized. The limits of detections were found to be 0.0026 and 0.0032 μg mL-1 for Mn(II) and Zn(II) respectively by applying a preconcentration factor ~30. The proposed enrichment method was applied successfully for the determination of Mn(II) and Zn(II) in biological and human hair samples. The proposed method was compared with reported methods in terms of Student’s ‘t’-test and Variance ratio ‘f’-test which indicates that there is no significant difference between proposed and literature method at 95 % confidence level.