Inter. J. of Chemical and Analytical Science
ISSN NO: 0976-1209
International Journal of Chemical and Analytical Science (IJCAS) is a international journal which publishes high quality original research articles, reviews, short communications, and case reports that contribute significantly to the advancement of the scientific knowledge in the following categories:
  • PHARMACEUTICAL CHEMISTRY:
    • Synthesis and biological studies.
    • QSAR.
    • Novel drug design.
    • Rational drug design combinatorial and parallel synthesis.
    • Estimation of drug.
    • Method developments.
    • Analysis of various pharmaceutical drugs.
    PHARMACEUTICAL ANALYSIS:
    • Medicinal chemistry
    • Organic and synthetic chemistry
    • Natural products chemistry
It's online copy circulated to all bonafide members of JPR Solutions. The Editorial Board of IJCAS comprises of eminent scientists and pharmacists from reputed institutions worldwide.
Impact Factor TM ( India ) = 0.911 as on date (12.05.2017)

Manuscripts Published

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 9.
Article Id: JPRS-MD-0000382
Title: Production of chitosan from marine trash crustaceans and its application in mercury removal from seawater
Category: Marine Drugs
Section: Research Article
Country: India
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The marine bycatch resources especially trash crustaceans can be effectively utilized in producing cheaper means of chitosan; a bioactive substance exhibiting peculiar properties, such as: biodegradability, biocompatibility, adsorption, selective permeability, chelation, ion exchange properties, antitumor and antimicrobial activities. In this present study chitosan is produced from trash crustaceans in bulk quantities indulging minimal infrastructural facilities in laboratory scale. The experimental protocol showed a 3-4 times the production of chitin and chitosan by applying the minimal chemicals. It is then subjected to mercury adsorption from sea water. The FT-IR spectroscopy analysis of the so produced chitosan showed considerable quality of the product as per with the industrial grade chitosan. At the same time proving the former a better choice than the latter for the adsorption of heavy metal (Hg) from the marine resources.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 9.
Article Id: JPRS-SDS-0000383
Title: Synthesis of Some Novel N- Acetyl Derivative of Sulpha Drugs and Their Biological Activities.
Category: Synthetic Drug Study
Section: Research Article
Country: India
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Six Acetyl derivatives of some Sulpha drugs ( Sulfadoxine[1] , Sulfadimidine[2] , Sulphamethoxazole[3], Sulphadiazine[4], Dapsone[5] and Sulphamethaxazole [6] were synthesized. COCH3 group was introduced into heterocyclic framework of the Sulpha drugs. The derivatives (1A, 2A, 3A, 4A, 5A and 6A) were characterized by melting point, UV and IR spectroscopies, elemental analysis and Thin layer chromatography. The compounds were screened against Aspergillus niger, E.Coli and Staphylococcus aureus. Some of the derivatives were found to possess higher activities than the parent drugs. Toxicological studies were carried out by investigating the effect of administration of the parent drugs and derivatives on Alkaline phosphatase (ALP) activities of serum, liver and kidney of Albino rats. Overall, it was revealed that the derivatives exhibited lower toxicity on tested organs than the parent drugs.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 9.
Article Id: JPRS-AC-0000384
Title: Determination of Mineral Composition and Metal Content of Nutraceutically Valued Plant- Embelia basal
Category: Analytical Chemistry
Section: Research Article
Country: India
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Embelia basal (R. & S.) A. DC, a shrub from family Myrsinaceae is a well known traditional medicine from ancient times. Various species of Embelia are used in Ayurveda for therapeutic purposes. Embelia basal contains health promoting factors such as minerals and metals in different concentrations which is used in indigenous medicines. Fruits of Embelia basal are quantified using atomic absorption spectrophotometer. Metal analysis of fruits shows the presence of vital essential minerals. The majority of the plant material is rich in some essential minerals like Fe, K, Zn, Cu, Mg, Ca, Al, Mn along with N and P 2O5 which are known to be beneficial for health. The quantitative metal analysis shows the presence of trace amount of Nickel and Cobalt. The present study provides fundamental data on the availability of some essential minerals, which can be useful to provide dietary information for designing value added foods and for food biofortification. These results may help in the development of new drug formulations.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 9.
Article Id: JPRS-NPs-0000385
Title: Antimicrobial activity of ß-asarone from Acorus calamus leaves
Category: Natural Products
Section: Research Article
Country: India
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Plants have evolved a number of inducible defence mechanisms against pathogen attack. Acorus calamus known as Vach in Hindi has also been credited with many medicinal properties. An antimicrobial substance ß-asarone was isolated from the methanolic extract of Acorus calamus leaves using various chromatographic procedures. The antibiotic was identified as ß-asarone on the basis of the FTIR, 1H- NMR, and FAB Mass spectral data. Antimicrobial activity of Acorus calamus rhizomes was evaluated in vitro. Different concentrations of ß–asarone isolated from methanolic extract (20-100 μg/ml) were tested and the antimicrobial activity was observed from 40 μg/ml and the zone of inhibition increased with concentration. ß –asarone inhibited growth of bacteria E. coli in a range of 40-100 μg/ml. The growth of fungi A. niger was slightly suppressed by ß-asarone in a range of 80-100 μg/ml. This is the first study to demonstrate in vitro antifungal activity of ßasarone against micro-organisms Escherichia coli and Aspergillus niger.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 9.
Article Id: JPRS-SDS-0000386
Title: Synthesis, Anti-inflammatory and Antimicrobial Evaluation of 2-mercaptobenzimidazole Derivatives
Category: Synthetic Drug Study
Section: Research Article
Country: India
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Anti-inflammatory and antimicrobial activities were evaluated for newly synthesized 2-mercaptobenzimidazole derivatives by carageenan induced paw edema method and cup plate method respectively. Totally a series of 2-mercaptobenzimidazole derivatives (1A-1J) were synthesized by mannich reaction from 2- mercaptobenzimidazole by reaction with compounds having secondary amine and formaldehyde. The purity of the synthesized compounds was checked by melting point and TLC and their structure was established by various analytical techniques such as IR and 1HNMR spectral studies. All the synthesized compounds exhibited significant anti-inflammatory activity and showed mild to moderate antibacterial and antifungal activities.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 9.
Article Id: JPRS-AC-0000387
Title: Three Simple Spectrometric Methods For Metoprolol Succinate In Tablet Form
Category: Analytical Chemistry
Section: Research Article
Country: India
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Three simple, precise and economical UV methods have been developed for the estimation of Metoprolol succinate in pharmaceutical dosage form. Method A is Absorbance maxima method, Metoprolol succinate has the absorbance maxima at 273.0 nm, Method B is the first order derivative spectra, the absorbance was measured at lmaxima = 284 nm and λminima = 260 nm with 272 nm as zero crossing point and amplitude difference was measured for the respective concentration of standard and was plotted against concentration and regression equation was calculated. Method C applied was area under curve (AUC), in the wavelength range of 244-294 nm. Linearity for detector response was observed in the concentration range of 25-200 μg/ml for all three methods. The proposed methods were successfully applied for the determination of Metoprolol succinate in commercial pharmaceutical preparation. The results were validated statistically as per ICH
guideline. It was found to be satisfactory.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 1, Issue: 9.
Article Id: JPRS-PC-0000388
Title: Advances In HPLC Column Packing
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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High Performance Liquid Chromatography (HPLC) is a highly improved form of column chromatography in which instead of a solvent being allowed to drip through a column under gravity, it is forced through under high pressures of up to 400 atmospheres(500-5000 p.s.i). The sensitivity and range of the technique depends on the choice of column and on the efficiency of the overall system. Column technology has seen great developments over the years. The transition from large porous particles and pellicular materials to small porous particles occurred in the early 1970s, when micro particulate silica gel (10 -mm dp) came into light and appropriate packing methods were developed. Monolithic columns are a promising alternative to packed columns in the future but much of the research is yet to be done. The use of CAPILLARY COLUMNS (4 mm) has increased in recent years, in part because small-diameter columns use much less solvent and provide higher sensitivity. While speaking of the future of packaging development, silica gel with chemically bonded phases will be around for a long time. The field is a promising one with great scope for research and development.