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International Journal of Chemical and Analytical Science (IJCAS) is a international journal which publishes high quality original research articles, reviews, short communications, and case reports that contribute significantly to the advancement of the scientific knowledge in the following categories:
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PHARMACEUTICAL CHEMISTRY:
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Synthesis and biological studies.
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QSAR.
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Novel drug design.
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Rational drug design combinatorial and parallel synthesis.
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Estimation of drug.
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Method developments.
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Analysis of various pharmaceutical drugs.
PHARMACEUTICAL ANALYSIS:
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Medicinal chemistry
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Organic and synthetic chemistry
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Natural products chemistry
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It's online copy circulated to all bonafide members of JPR Solutions. The Editorial Board of IJCAS comprises of eminent scientists and pharmacists from reputed institutions worldwide.
Impact Factor TM ( India ) = 0.918 as on date (12.03.2018)
Manuscripts Published
Title: Method development and Validation of Reverse Phase HPLC Method for the Determination of Dithranol in Pharmaceutical Ointment Forms
Category: Analytical Chemistry
Section: Research Article
Author Affiliation: TherDose Pharma Pvt. Ltd, Plot No. 118-120, Road No.5, ALEAP Ind. Est., Pragathi Nagar, Opp. JNTU, Hyderabad, Andhra Pradesh – 500072.
View Article
A simple and rapid reverse phase high performance liquid chromatography (RP-HPLC) method was developed and validated for quantitative determination of dithranol in Ointments. Dithranol was analyzed by using reverse phase Phenomenex C18 column (4.6mm x 25cm, 5microns) with mobile phase consisting of acetonitrile: water: TFA (60:40:0.05%v/v). The flow rate was set 1.2ml/min and the analysis was performed at wavelength 254nm using Photo Diode Array (PDA) detector at 25°C temperature. The method was validated and stability studies were conducted under different conditions. The retention time for dithranol was around 10.2minutes. The developed method was successfully applied to estimate the amount of dithranol in ointment formulations and it is the stability indicating method.