Inter. J. of Chemical and Analytical Science
ISSN NO: 0976-1209
International Journal of Chemical and Analytical Science (IJCAS) is a international journal which publishes high quality original research articles, reviews, short communications, and case reports that contribute significantly to the advancement of the scientific knowledge in the following categories:
  • PHARMACEUTICAL CHEMISTRY:
    • Synthesis and biological studies.
    • QSAR.
    • Novel drug design.
    • Rational drug design combinatorial and parallel synthesis.
    • Estimation of drug.
    • Method developments.
    • Analysis of various pharmaceutical drugs.
    PHARMACEUTICAL ANALYSIS:
    • Medicinal chemistry
    • Organic and synthetic chemistry
    • Natural products chemistry
It's online copy circulated to all bonafide members of JPR Solutions. The Editorial Board of IJCAS comprises of eminent scientists and pharmacists from reputed institutions worldwide.
Impact Factor TM ( India ) = 0.918 as on date (12.03.2018)

Manuscripts Published

Journal: Inter. J. of Chemical and Analytical Science, Volume: 5, Issue: January
Article Id: JPRS-AC-00001152
Title: Stability- Indicating High Performance Thin Layer Chromatography Determination of Tenofovir Disoproxil Fumarate in Bulk and Tablet Dosage Form
Category: Analytical Chemistry
Section: Research Article
Country: India
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Stability-indicating high-performance thin-layer chromatographic method of tenofovir disoproxil fumarate both as a bulk drug and in formulation was developed and validated as per the International Conference on Harmonization guidelines .The method employed TLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. The solvent system consisted of butanol: ethyl acetate: acetic acid (4.5:0.5:0.3 v/v) and densitometric analysis was carried out in the absorbance mode at 260 nm. The system was found to give compact spot for tenofovir disoproxil fumarate (Rf value of 0.51 ± 0.02). The linear regression analysis data for the calibration plots showed good relationship with r2= 0.9999 ± 0.0001 in the concentration range 300 – 1800 ng/spot. Tenofovir disoproxil fumarate was subjected to acid and alkali hydrolysis, oxidation, thermal degradation and photo degradation. There was no interference of the excipients on the determination of the active pharmaceutical ingredients. Proposed method is precise, selective and accurate for the estimation of tenofovir disoproxil fumarate in the bulk and dosage form.

Cite This article as: Charushila H. Bhirud *, Dr.S.N.Hiremath,Stability- Indicating High Performance Thin Layer Chromatography Determination of Tenofovir Disoproxil Fumarate in Bulk and Tablet Dosage Form,International Journal of Chemical and Analytical Science 2014,5(1),1-5.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 5, Issue: January
Article Id: JPRS-AC-00001155
Title: Application of response surface methodology in lithium recovery from highly concentrated solutions containing Mg2+ ions
Category: Analytical Chemistry
Section: Research Article
Country: India
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The technique of Response surface methodology (RSM) is an integration of experimental strategies, mathematical methods and statistical inference which allows for simultaneous variation of several factors to find the optimal level giving the most interesting response. In this work this method was applied in order to establish the optimum conditions (Al/Li molar ratio, pH and reaction time) for lithium trapping using RSM methodology in presence of Mg2+ ions. The optimum values of these factors were found to be 4, 8.4 and 4h25min respectively. A 24-1 fractional factorial design and central composite design were employed for experimental design and analysis of the results. Predicted values are tested. The obtained results indicate that maximal lithium trapping is 95% and magnesium remaining in solution is 72%. For reducing the magnesium retained in the aluminum gel, washing with distilled water is indispensable. This operation has increased the total percentage of recovered magnesium in solution which reaches 97%. It should be noted that this operation reduces slightly the Li trapping only from 1 to 2%.

Cite this article as: A. Somrani, A. H. Hamzaoui and A. M’Nif,Application of response surface methodology in lithium recovery from highly concentrated solutions containing Mg2+ ions,International Journal of Chemical and Analytical Science 2014,5(1),11-14

Journal: Inter. J. of Chemical and Analytical Science, Volume: 5, Issue: January
Article Id: JPRS-AC-00001156
Title: Fabrication of Nafion/HRP-SWCNT/MWCNT-ZnO based alcohol biosensor: Diagnostics for forensic analysis
Category: Analytical Chemistry
Section: Research Article
Country: India
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Nafion/HRP-SWCNT/MWCNT-ZnO working electrode was fabricated. The principle enzyme alcohol oxidase was immobilized on inner surface of PVC beaker which forms the body of electrochemical cell. Optimization of the sensor system was performed and, for electrochemical measurements, a potential (E) of -50 mV versus Ag/AgCl reference electrode was chosen in 0.1M sodium phosphate buffer at pH 8.0. The ethanol content in standard solutions was determined and the biosensor exhibit a linear range from 10 µM to 750 µM with detection limit of 10 µM and a response time of about 10s. These characteristics allowed its application for detection of alcohol concentration in the saliva and blood samples. Therefore, the present study demonstrated that immobilized alcohol oxidase has high specificity toward ethanol and showed good storage stability, which may be of considerable interest for clinical and forensic application.

Cite this article as:Anjum Gahlaut, Monika Dahiya,Rekha Dhull,Neeraj Dilbagi, Fabrication of Nafion/HRP-SWCNT/MWCNT-ZnO based alcohol biosensor:Diagnostics for forensic analysis,International Journal of Chemical and Analytical Science 2014,5(1),15-20.

 

Journal: Inter. J. of Chemical and Analytical Science, Volume: 5, Issue: January
Article Id: JPRS-AC-00001158
Title: The polarographic study of Cobalt(II)-dithiocarbamate complexes at DME
Category: Analytical Chemistry
Section: Research Article
Country: India
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Cobalt is a naturally occurring element in the earth’s crust. It is a very small part of our environment and very small amounts are needed for many animals and humans to stay healthy. Cobalt poisoning can occur when exposed to large amounts of cobalt. The aim of this study was to develop a facile, rapid, robust, sensitive and selective methodology for the determination of cobalt(II). Two new ligands, ammonium 2,6-dimethyl morpholine dithiocarbamate (ADMM-DTC) and ammonium 3-methyl piperdine dithiocarbamate (AMP-DTC) were synthesized in the laboratory. The method was based on chelation of cobalt(II) with ADMM-DTC/AMP-DTC in presence of NH4OH at pH 7.2 and 8.2 to produce catalytic hydrogen currents at -1.28 V and -1.38 V vs SCE respectively and prior detected by D.C polarography. Optimized polarogaphic conditions were established by studying effect of pH, supporting electrolyte (NH4Cl), ligand & metal ion concentrations and effect of adverse ions on peak height to improve the sensitivity, selectivity and detection limits of the present method. This technique is successfully applied for the analysis of cobalt(II) in different matrices with recoveries ranging from 93- 98 % and the results obtained were comparable with the differential pulse polarography (DPP).

Cite this article as:C. Giridhar, S. Kanchi, T. Niranjan, N. Venkatasubba Naidu,The polarographic study of Cobalt(II)-dithiocarbamate complexes at DME,International Journal of Chemical and Analytical Science 2014,5(1),24-32.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 5, Issue: January
Article Id: JPRS-PC-00001159
Title: Evaluation of the Angiosuppresive Activity of Prodigiosin Using the Chorioallantoic Membrane Assay
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Angiogenesis is a process of new blood vessel development that performances a crucial function in embryonic development and many pathological situation encompassing cancer. The potential use of natural products in antiangiogenesis is to be appreciated especially their role in chemoprevention. In the present study, we investigated the antiangiogenic properties of red pigment isolated from marine bacteria Vibrio sps. This pigment was further purified and characterized by physical and chemical characteristics using TLC, UV–vis Spectroscopy, NMR H, and C NMR and confirmed as prodigiosin. The chicken-chorioallantoic-membrane (CAM) assay using quail eggs was applied to test for antiangiogenic effects of prodigiosin. The antiangiogenic activity of prodigiosin implicates their possible application for diseases where inhibition of blood vessel formation is desired.

Cite this article as: Pabba Shiva Krishna, Gudikandula Krishna, Laxminarayana Eppakayala, Reddy Shetty Prakasham and M.A.Singara Charya ,Evaluation of the Angiosuppresive Activity of Prodigiosin Using the Chorioallantoic Membrane Assay,International Journal of Chemical and Analytical Science 2014,5(1),33-38

Journal: Inter. J. of Chemical and Analytical Science, Volume: 5, Issue: January
Article Id: JPRS-SM-00001160
Title: Antagonistic effect of rhizospheric Aspergillus species against Fusarium oxysporum f. sp. lycopersici
Category: Secondary Metabolites
Section: Research Article
Country: India
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Aim: The present research work was carried out to evaluate the efficacy of five Aspergillus species as biocontrol agent against the Fusarium oxysporum f. sp. lycopersici, the causal organism of tomato wilt disease, in in vitro condition. Materials and methods: Isolation and identification of F. oxysporum f. sp. lycopersici pathogen and In-vitro screening of antagonist native bio agents against F. oxysporum f. sp. lycopersici form tomato cultivated soil were collected from different areas in and around Mysore district which is located between latitude 11°45' to 12°40' N and longitude 75°57' to 77°15' E, Karnataka state, India. Five Aspergillus isolates were evaluated for their antagonistic activity against Fusarium oxysporum f. sp. lycopersici following the dual culture technique in vitro. Results: Biological control is an innovative, cost-effective and eco-friendly approach for control of diseases. In the present study, the bio-agents, isolated from indigenous soil, were identified based on morphological characteristics and spore structure. Five Aspergillus isolates, isolated from indigenous soil, displayed significant antagonistic activity and suppressed the growth of the pathogen. Among five, A. niger inhibited 80.33% growth of the pathogen, A. flavus isolate 1 and A. tamarii inhibited 77.03% growth of the pathogen when compared to control.

Cite this article as: Anil Kumar R. and RajKumar H. Garampalli,Antagonistic effect of rhizospheric Aspergillus species  against Fusarium oxysporum f. sp. lycopersici, International Journal of Chemical and Analytical Science 2014,5(1),39-42.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 5, Issue: January
Article Id: JPRS-AC-00001163
Title: Stability-indicating HPTLC determination of mefenamic acid in bulk drug and pharmaceutical formulations.
Category: Analytical Chemistry
Section: Research Article
Country: India
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High-performance thin-layer chromatographic method was described for the analysis of Mefenamic acid in powder and in pharmaceutical formulations. The method employed HPTLC aluminum plates precoated with silica gel 60F254 as the stationary phase and mixture of petroleum ether–chloroform–glacial acetic acid (5.0 : 3.0 : 0.5, v/v/v) as mobile phase. This system gave compact spots for Mefenamic acid with Rf value of 0.60. Densitometric analysis of mefenamic acid was carried out in the absorbance mode at 283 nm. The linear concentration range was 0.2–3.0 µg per spot with correlation coefficient of 0.9987. The limits of detection and quantitation were 0.09 and 0.30 µg per spot, respectively. Mefenamic acid was subjected to acid and alkali hydrolysis, oxidation and photodegradation. The degraded product was well separated from the parent drug. The drug does not undergo degradation under photo, oxidative and acidic conditions. Degradation with sodium hydroxide showed additional spot at Rf value of 0.32. This indicates that the drug is susceptible to alkaline degradation. Statistical analysis proves that the method is repeatable and selective for the estimation of this drug. As the method could effectively separate the drug from its degradation product, it considered as a stability-indicating one. Furthermore, the method was successfully applied for mefenamic acid analysis in commercially available tablets.

Cite this article as: Safaa F. Saleh, Sayed M. Dereaya  and Mahmoud A.Omar,Stability-indicating HPTLC determination of mefenamic acid in bulk drug and pharmaceutical formulations,International Journal of Chemical and Analytical Science 2014,5(1),55-60.