Inter. J. of Chemical and Analytical Science
ISSN NO: 0976-1209
International Journal of Chemical and Analytical Science (IJCAS) is a international journal which publishes high quality original research articles, reviews, short communications, and case reports that contribute significantly to the advancement of the scientific knowledge in the following categories:
  • PHARMACEUTICAL CHEMISTRY:
    • Synthesis and biological studies.
    • QSAR.
    • Novel drug design.
    • Rational drug design combinatorial and parallel synthesis.
    • Estimation of drug.
    • Method developments.
    • Analysis of various pharmaceutical drugs.
    PHARMACEUTICAL ANALYSIS:
    • Medicinal chemistry
    • Organic and synthetic chemistry
    • Natural products chemistry
It's online copy circulated to all bonafide members of JPR Solutions. The Editorial Board of IJCAS comprises of eminent scientists and pharmacists from reputed institutions worldwide.
Impact Factor TM ( India ) = 0.911 as on date (12.05.2017)

Manuscripts Published

Journal: Inter. J. of Chemical and Analytical Science, Volume: 5, Issue: 2.
Article Id: JPRS-AC-00001166
Title: Synthesis and investigation of photophysical properties of imidazobenzothiadiazoles
Category: Analytical Chemistry
Section: Research Article
Country: India
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Benzothiadiazole scaffold containing molecules are important precursors to derivatives with applications in several areas. We report a facile method of synthesis of a few imidazobenzothiadiazoles using La(OTf)3 as catalyst. The structures of these compounds were characterized by IR, 1HNMR, 13C NMR and mass spectroscopy. Benzothiadiazoles act as electron acceptors and on conjugation with electron donors they assume a greater significance in material science. Imidazobenzothiadiazoles embodies both electron acceptors and electron donors in their structure and hence we have investigated their absorption and fluorescence properties. The effect of solvent polarity on the photo physical properties of imidazobenzothiadiazoles was investigated in different solvents of varying polarity. Imidazobenzothiadiazoles were found to be weak fluorescing and showed a solvent and compound specific solvatochromism. The quantum yields are varying in between 7.4x10-3 and 9x10-5. A direct relationship was found between wavelength of emission and the quantum yield. Larger fluorescence quantum yields were observed when the lone pair of electrons on the imidazolo tertiary nitrogen accepts hydrogen from the proton donor solvent like ethyl alcohol and water than in DMSO. The fluorescence was dependent on the polarity of the solvents. Efficient fluorescence was observed in a polar and protic solvent. These compounds show lower Stokes shift and vary in between 50 nm and 135 nm. A decreased Stokes shift was observed in water medium than in the remaining solvent media.

Cite this article as:Anwita Mudiraj, Gajula Raju and A. Ram Reddy,Synthesis and investigation of photophysical properties of imidazobenzothiadiazoles,International Journal of Chemical and Analytical Science 2014,5(2),73-79.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 5, Issue: 2.
Article Id: JPRS-SDS-00001165
Title: Comprehensive study on the production of single phase nickel doped Zinc Oxide nanoparticles by mixture of fuel approach for DMS applications
Category: Synthetic Drug Study
Section: Research Article
Country: India
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The evolution of semiconductor industry has brought about echelon of growth in the electronics industry. The introduction of magnetic properties to these materials has spurred a magnanimous growth in the spintronics industry. One of the major concerns in this industry is the production of highly ferromagnetic semiconductors due to absence of critical methods to produce the same. In this paper, a novel autocombustion method using ammonium acetate as the fuel has been described which can produce single phase nickel doped zinc oxide nanoparticles in a single step process. The produced particles were tested for their single phase nature and confirmed to be the same using Reitveld refinement methods and x-ray photoelectron spectroscopy. The ferromagnetic property of nickel doped zinc oxide was tested and a linear growth of the susceptibility was observed with increasing concentrations of nickel in the sample. The optical properties proved the presence of defect states and oxygen vacancies in the sample arising due to the addition of nickel to the sample. This paper gives a complete comprehensive study on the production of single phased nickel doped zinc oxide nanoparticles with concentrations varying from 2% to 25% by analyzing their structural, morphological, chemical, magnetic and optical properties.

Cite this article as:V. Rajendar, N. Prudhvi Raju, K. Shobhan, I. Srikanth, K. Venkateswara Rao,Comprehensive study on the production of single phase nickel doped Zinc Oxide nanoparticles by mixture of fuel approach for DMS applications,International Journal of Chemical and Analytical Science 2014,5(2),64-72.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 5, Issue: 2.
Article Id: JPRS-SDS-00001170
Title: Determination of zolpidem in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a clinical pharmacokinetic study
Category: Synthetic Drug Study
Section: Research Article
Country: India
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Background: Zolpidem is a non-benzodiazepine hypnotic of the imidazopyridine class and is available in 5 mg and 10 mg strength tablets for oral administration. A simple, rapid and sensitive high throughput liquid chromatographic method coupled with tandem mass spectrometry (LC–MS/MS) has been developed and validated to quantify zolpidem in human plasma using mirtazapine as internal standard. Methods: The analyte and internal standard were extracted from 300 ìL plasma via solid phase extraction and were separated on a Hypurity Advance C-18 column (150 × 4.6 mm, 5 µ) with isocratic elution using methanol: acetonitrile: 5 mM ammonium acetate solution (75: 20: 5, v/v/v) as mobile phase. The protonate of analyte was quantitated in positive ionization by multiple reaction monitoring with a mass spectrometer. The mass transitions m/z 308.4/235.1 and m/z 266.2/195.1 were used to measure zolpidem and mirtazapine respectively. Results: The proposed method validated for a linear dynamic range of 0.5-550 ng/mL with a correlation coefficient = 0.99, where the regression model (1/x2) was best fitted. The intra- and inter-day batches precision (%CV) across the three validation batches (LOQQC, LQC, MQC and HQC) were in the ranged of 4.4-5.7% and 4.9-6.1% respectively. The intra- and inter-day accuracies at different levels of QC were within ± 7%. The drug was found to be stable after a number of stability studies. This method competes with all the regulatory requirements for selectivity, sensitivity, linearity, precision, accuracy and stability for the determination of zolpidem. Conclusions: The validated method was successfully applied in the analysis of zolpidem levels in a clinical pharmacokinetic bioequivalence study following oral administration of zolpidem 10 mg tablets.

Cite this article as:Kuldeep K Namdev, Manoj K Singh, Swapnil Sharma, Jaya Dwivedi,Determination of zolpidem in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a clinical pharmacokinetic study,International Journal of Chemical and Analytical Science 2014,5(2),99-106.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 5, Issue: 2.
Article Id: JPRS-SDS-00001169
Title: Efficient, stable and reusable Bi2O3/ZrO2 catalyzed one-pot synthesis of 3, 4-dihydropyrimidi-2(1H)-ones under solvent-free conditions
Category: Synthetic Drug Study
Section: Research Article
Country: India
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3,4-Dihydropyrimidin-2-(1H)-ones were synthesized in high yields by a one-pot cyclocondensation of an aldehyde, 1,3-dicarbonyl compound and urea using Bi2O3/ZrO2 as a recyclable catalyst under solvent-free conditions in short reaction time (2–3.5 h). Bi2O3/ZrO2 catalyst with Bi2O3 loading (3 wt %) was prepared by the wet impregnation method. This catalyst was characterized by various techniques, such as SEM, XRD, FT-IR and elemental analysis. Bi2O3/ZrO2 was found to be stable and efficient to catalyze one-pot Biginelli reaction in solvent-free conditions. The catalyst is recovered by pouring reaction mixture into cold water and filtration.

Cite this article as: Vijaya Charan Guguloth, Gajula Raju, Manohar Basude and Satyanarayana Battu, Efficient, stable and reusable Bi2O3/ZrO2 catalyzed one-pot synthesis of 3, 4-dihydropyrimidi-2(1H)-ones under solvent-free conditions,International Journal of Chemical and Analytical Science 2014,5(2),86-92.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 5, Issue: 2.
Article Id: JPRS-AC-00001154
Title: Simultaneous estimation of Pyronaridone Tetraphosphate and Artesunate in Bulk and Combined Tablet Dosage form by RP-HPLC.
Category: Analytical Chemistry
Section: Editorial
Country: India
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A simple, sensitive, linear, precise and accurate method by Gradient RP-HPLC for the simultaneous estimation of Pyronaridone Tetraphosphate and Artesunate in Bulk and in their combined Tablet Dosage form was developed and validated. The separation of the two drugs was based on the use of Inertsil ODS 3V (250 × 4.6 mm, i.d., 5 ìm) column in a Gradient mode. Mobile phase consisted of 0.1% orthophosphoric acid (Solvent A) and Acetonitrile (Solvent B) was set with gradient programming for 20 min and was delivered at 1 ml/min flow rate and effluents are achieved with variable wavelength PDA detector at 220 nm. The retention times of Pyronaridone Tetraphosphate and Artesunate were found to be 2.17 minutes and 11.59 minutes respectively. The percentage assay of Pyronaridone Tetraphosphate and Artesunate was found to be 99.39% and 99.95% respectively. Calibration curves were linear for PYT and ART at concentration ranges of 72-216 ìg/ml, and 24-72 ìg/ml with the regression coefficient of 0.999 for both the drugs and precise with (%RSD<2). The LOD for PYT and ART was found to be 1.8 ìg/ml and 0.06 ìg/ml and LOQ for PYT and ART was found to be 5.4 ìg/ml and 1.8 ìg/ml respectively. The method was validated by determining its linearity, accuracy, precision, system suitability and can be employed for routine quality control analysis as per ICH guidelines.

Cite this article as: K. Neelima, Y. Rajendra Prasad,Simultaneous estimation of Pyronaridone Tetraphosphate and Artesunate in Bulk and Combined Tablet Dosage form by RP-HPLC,International Journal of Chemical and Analytical Science 2014,5(2),93-98