Inter. J. of Chemical and Analytical Science
ISSN NO: 0976-1209
International Journal of Chemical and Analytical Science (IJCAS) is a international journal which publishes high quality original research articles, reviews, short communications, and case reports that contribute significantly to the advancement of the scientific knowledge in the following categories:
  • PHARMACEUTICAL CHEMISTRY:
    • Synthesis and biological studies.
    • QSAR.
    • Novel drug design.
    • Rational drug design combinatorial and parallel synthesis.
    • Estimation of drug.
    • Method developments.
    • Analysis of various pharmaceutical drugs.
    PHARMACEUTICAL ANALYSIS:
    • Medicinal chemistry
    • Organic and synthetic chemistry
    • Natural products chemistry
It's online copy circulated to all bonafide members of JPR Solutions. The Editorial Board of IJCAS comprises of eminent scientists and pharmacists from reputed institutions worldwide.
Impact Factor TM ( India ) = 0.911 as on date (12.05.2017)

Manuscripts Published

Journal: Inter. J. of Chemical and Analytical Science, Volume: 6, Issue: 1.
Article Id: JPRS-AC-00001218
Title: Wet chemical method for determination of free carbon content in boron carbide
Category: Analytical Chemistry
Section: Research Article
Country: India
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A wet chemical method has been developed for the estimation of free carbon in boron carbide. A chromic-sulfuric acid mixture is used to selectively oxidize the free carbon to carbon dioxide which is precipitated as barium carbonate in a known excess of barium hydroxide solution. The free carbon content is then calculated from the barium hydroxide consumed.

 

Cite this article as:D. Annie, V. Chandramouli, S. Anthonysamy,Wet chemical method for determination of free carbon content in boron carbide,International Journal of Chemical and Analytical Science 2016,7(1),1-4.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 6, Issue: 1.
Article Id: JPRS-PC-00001162
Title: A new, simple and rapid method for simultaneous determination of ethambutol and isoniazid in dried blood spots by LC-MS/MS and its application to pharmacokinetic study.
Category: Pharmaceutical Chemistry
Section: Research Article
Country: India
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Background: Ethambutol (EMB) and isoniazid (INH) are first-line anti tubercular drugs. The combination formulation is used for the continuation phase of tuberculosis. A new, simple and rapid method for simultaneous determination of ethambutol and isoniazid in dried blood spots (DBS) was developed and validated using LC-MS/MS. This method was successfully applied to pharmacokinetic study following oral administration of tablet of fixed dose combination containing ethambutol hydrochloride 800 mg and isoniazid 300 mg in human volunteers. Methods: Whole blood samples were spotted, dried and a 3 mm punch was extracted with methanol. The separation was performed on kromasil C18 column (150×4.6mm i.d., 5µm particle size) using a mobile phase composed of 0.1% formic acid in water and methanol (35:65 v/v) at a flow rate of 0.8 mL/min. The total run time was 3.5 min with retention times of 1.34 min for EMB, 1.90 for INH and 2.44 for IS. Results: The method was linear over the concentration range of 50-4000 ng/mL for EMB and 100-5500 ng/mL for INH with all correlation coefficients greater than 0.9943 and 0.9941 for EMB and INH respectively. The intra-day accuracy of the method was ranged from 95.5% to 103.4% and the inter-day accuracy was between 97.8% and 103.8% with the precision less than 8.4 and 7.5% respectively. The stability of both the analytes was evaluated under various conditions. Conclusion: The method described here was validated in accordance with “Guidance for industry: Bioanalytical method validation, USFDA (2001)” and the method was successfully applied to the pharmacokinetic study after oral administration. DBS technique has been demonstrated to produce similar PK profiles as that of plasma quantitation methods, supporting the use of DBS as an alternative for plasma pharmacokinetic studies.

Cite this article as: P Pavan Kumar, T E G K Murthy,A new, simple and rapid method for simultaneous determination of ethambutol and isoniazid in dried blood spots by LC-MS/MS and its application to pharmacokinetic study,International Journal of Chemical and Analytical Science 2014,5(1),49-54.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 6, Issue: 1.
Article Id: JPRS-AC-00001789
Title: Spectral studies of N’’-[(1Z,2Z)-2-(hydroxyimino)-1-phenylpropylidene]-N’’’-[(Z)-(2-hydroxyphenyl)methylidene]thiocarbonohydrazide(HINSALTH) metal complexes.
Category: Analytical Chemistry
Section: Research Article
Country: India
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The complexes of new ligand with the transition metal Co (II), Ni (II), Cu (II), and Zn (II) have been synthesizedandreported for the first time. Ligand act as the ambidentate nature. The geometry of the complexes investigated on the basis of magnetic susceptibility and spectral data. IR studies shows that the ligand behaves as bidentate in metal like Co(II), Ni(II), Cu(II), Zn(II)and coordinate through oximino and azomethanine nitrogen. Based on these results probable structure of these complexes have been proposed, for Ni(II), Zn(II) tetrahedral, Ni(II) octahedral and Cu(II) have square planar structure.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 6, Issue: 1.
Article Id: JPRS-AC-00001167
Title: Simultaneous determination of Lansoprazole and Metronidazole in Pharmaceutical Dosage Form by Reversed Phase- High Performance liquid Chromatography
Category: Analytical Chemistry
Section: Research Article
Country: India
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A simple, selective, rapid, precise and economical reverse phase HPLC method has been developed for the simultaneous estimation of Lansoprazole and Metronidazole in Pharmaceutical dosage forms. The method was carried out on a C18 (25 cm×4.6 mm i.d, 5 µm particle size) column with a mobile phase consisting of Acetonitrile ,water and Triethanol amine(pH 7.3 by addition of O-phosphoric acid) (40:60:1 v/v) at a flow rate of 1 ml/min. Detection was carried out at 290nm with UV detector. The retention time of Metronidazole and Lansoprazole was 3.14 and 10.13 min, respectively. The developed method was validated in terms of accuracy, precision, linearity, limit of detection and limit of quantitation .The calibration curves were linear with R2 between 0.99to 1.0 over a concentration range of 5-25 µg/ml for Metronidazole and 2-10 µg/ml for Lansoprazole . The RSD for intraday and interday precision was <1.0%.The proposed method can be used for the estimation of these drugs in combined dosage forms. Degradation studies showed that solutions of both the drug were stable for 5 hr at room temperature but both the drug showed degradation when subjected to thermal and photodegradation.

Cite this article as: Snehal Y. Kane, Snehalatha B., Munira Momin,Simultaneous determination of Lansoprazole and Metronidazole in Pharmaceutical Dosage Form by Reversed Phase- High Performance liquid Chromatography,International Journal of Chemical and Analytical Science 2014,5(2),80-85

Journal: Inter. J. of Chemical and Analytical Science, Volume: 6, Issue: 1.
Article Id: JPRS-AC-00001161
Title: Simultaneous determination of copper and cadmium as Cu(DDTC)2 Spectrophotometrically after fractional extraction
Category: Analytical Chemistry
Section: Research Article
Country: India
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Copper(II) and cadmium(II) forms M(DDTC)2 complexes (M=Cu, Cd) with diethyldithiocarbamate (DDTC) that is extracted in CHCl3/CCl4. Yellow Cu(DDTC)2 shows maximum absorbance at 435 nm whereas Cd(DDTC)2 has no absorption. Extract was divided into two fractions. Absorption of one fraction is directly measured which is equivalent to Cu(II) present in sample. Addition of excess copper(II) to the second fraction of the extract displaces cadmium quantitatively forming additional Cu(DDTC)2 as its stability is higher than Cd(DDTC)2. The absorbance of second extract is measured subsequently when additional absorbance is equivalent to cadmium. Linear calibration range was obtained 0.05–17 µg mL-1 for cadmium and 0.02–12 µg mL-1 for copper with the regression coefficient (r2) 0.998 for each. In the presence of EDTA as masking agent very good selectivity was achieved.

Cite this article as:Mohammad Nasir Uddin, Md. Muzahidul Islam, Nur Mostaq Shah,Simultaneous determination of copper and cadmium as Cu(DDTC)2 Spectrophotometrically after fractional extraction , International Journal of Chemical and Analytical Science 2014,5(1),43-49.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 6, Issue: 1.
Article Id: JPRS-PSPA-00001157
Title: Antihyperglycemic activity of Boerhaavia diffusa in streptozotocin induced diabetic rats
Category: Phytochemical Study and Pharmacological Activity
Section: Research Article
Country: India
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Background: Many Indian medicinal plants were investigated in streptozotocin induced diabetic rat model and provided scientific validation to prove their antihyperglycemic activity. In view of alleged antidiabetic potential, effect of the aqueous and methanol extracts of Boerhaavia diffusa (Nyctaginaceae) roots, was observed on fasting blood sugar levels in streptozotocin induced diabetic rats. Methods: Fasting plasma glucose levels were determined by an enzymatic method using a kit. Results: Results show that both the extracts significantly reduced the blood glucose level in STZ induced diabetic rats. Conclusion: A plausible mechanism of action is that the extracts might have stimulated the residual pancreatic beta-cell function or produced the hypoglycaemia.

Cite this article as: Deepti Malhotra, Fouzia Ishaq and Amir Khan,Antihyperglycemic activity of Boerhaavia diffusa in streptozotocin induced diabetic rats,International Journal of Chemical and Analytical Science 2014,5(1),21-23.

Journal: Inter. J. of Chemical and Analytical Science, Volume: 6, Issue: 1.
Article Id: JPRS-AC-00001153
Title: Analytical Techniques in Forensic Science: MS & Bio-Sensor based diagnostics
Category: Analytical Chemistry
Section: Review Article
Country: India
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Background/Objectives: Forensic science is a stream which owes its growth to the advancements in technology. Forensic science analyses samples or material evidences like blood, skin, semen, hair collected from the site of crime through detection techniques. Methods: Various analytical techniques including Gas/Liquid Chromatography, HPLC, Mass Spectrometry, Immunoassays, enzymatic assays, DNA profiling techniques, PCR, biosensing and metabolomics involved for forensic studies. LC-MS is efficient in telling the chemical nature of almost all kind of samples. DNA profiling provides the fingerprint of individual’s DNA which are used in criminal identification and solving disputes related to paternity and maternity. PCR allows gaining great deal of information from very limited amount of samples. Conclusion: Cumulative use of the detection techniques has totally changed the parameters of forensic analysis. The traces of samples can easily be analysed accurately and efficiently. This review provides an overview of the recent methods and technology used for forensic analysis.

Cite this article as:Anjum Gahlaut,Vikas Dhull, Monika Dahiya, Rajesh Dabur,Analytical Techniques in Forensic Science: MS & Bio-Sensor based diagnostics,International Journal of Chemical and Analytical Science 2014,5(1),6-10

 

 

Journal: Inter. J. of Chemical and Analytical Science, Volume: 6, Issue: 1.
Article Id: JPRS-AC-0000703
Title: Polarographic studies of Fe(II)-dithiocarbamate complexes at DME: Application to environmental samples
Category: Analytical Chemistry
Section: Research Article
Country: India
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Two new ligands, ammonium 4-phenylpiperazine-1-dithiocarbamate (Amm 4-PP-DTC) and ammonium 4-benylpiperidine-1-dithiocarbamate (Amm 4-BP-DTC) were synthesized in the laboratory. The method was based on chelation of iron (II) with Amm 4-PP-DTC / Amm 4-BP-DTC in presence of NH4OH at pH 6.2 and 6.6 to produce catalytic hydrogen currents at -1.31V and -1.50V vs SCE respectively and prior detected by DC polarography. Optimized polarographic conditions were established by studying effect of pH, supporting electrolyte (NH4Cl), ligand and metal ion concentrations and effect of adverse ions on peak height to improve the sensitivity, selectivity and detection limits. This technique is successfully applied for the analysis of iron (II) in different matrices with recoveries ranging from 96.25-99.76% and the results obtained were comparable with the AAS.