Inter. J. of Chemical and Analytical Science
ISSN NO: 0976-1209
International Journal of Chemical and Analytical Science (IJCAS) is a international journal which publishes high quality original research articles, reviews, short communications, and case reports that contribute significantly to the advancement of the scientific knowledge in the following categories:
    • Synthesis and biological studies.
    • QSAR.
    • Novel drug design.
    • Rational drug design combinatorial and parallel synthesis.
    • Estimation of drug.
    • Method developments.
    • Analysis of various pharmaceutical drugs.
    • Medicinal chemistry
    • Organic and synthetic chemistry
    • Natural products chemistry
It's online copy circulated to all bonafide members of JPR Solutions. The Editorial Board of IJCAS comprises of eminent scientists and pharmacists from reputed institutions worldwide.
Impact Factor TM ( India ) = 0.918 as on date (12.03.2018)

Manuscripts Published

Journal: Inter. J. of Chemical and Analytical Science, Volume: 7, Issue: Jan to December
Article Id: JPRS-AC-00001852
Title: Comparative study of analytical method development of fluconazole in tablets and capsule by ultraviolet spectrophotometric method
Category: Analytical Chemistry
Section: Research Article
Author Affiliation: Department of Quality Assurance, Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, Maharashtra, India
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Objective: This comparative study is aimed to develop and validate a simple, accurate, economic, and precise ultraviolet (UV) spectroscopic method for tablets and capsules of fluconazole. Percentage purity of fluconazole in tablets and capsule was determined using bracketing method. Method: The method involves the use of easily available inexpensive solvents that is distilled water. UV-visible spectrophotometer (Shimadzu, model 1800) which has two matched quartz cells with 1 cm light path and a detection wavelength of 261 nm using a UV detector. Results: A linear response was observed over the concentration range 5-25 μg/mL of fluconazole. Detection limit for fluconazole tablet and capsule was found to be 0.894 and 1.35, respectively. Quantitation limit for fluconazole tablet and capsule was found 2.71 and 4.1, respectively. The percentage purity was found 101.35% and 97.29% for tablet and capsule, respectively. Conclusion: The comparative study of proposed method gives analytical results which satisfy all validation parameters for both tablet and capsules. The method was successfully validated in accordance to ICH guidelines acceptance criteria for linearity, accuracy, precision, robustness, and ruggedness. Good precision and accuracy which prove the reliability of proposed method in different dosage form. Hence, this method can be used routinely for quantitative estimation of fluconazole in solid dosage form (tablet and capsule) by UV spectrophotometer. The literature survey revealed that various research works are done with fluconazole in bulk, tablet, capsule, and any other formulations. The present work gives detail account on comparative study of tablet and capsule for analytical method development and validation.