JPR:BioMedRx:An International Journal
ISSN NO: 2321-4988
BioMedRx journal is devoted to the promotion of Bio, Pharma and related disciplines (including medical, Nursing,Paramedical, Clinical   fields).It seeks to foster multi-disciplinary research and collaboration among scientists, pharmaceutical industries and healthcare sector as well as provide a National and international forum for the communication and evaluation of data, methods and opinions in pharmaceutical sciences and related disciplines.The Editor  welcome contributions of field relevance. Although primarily devoted to original research papers, the journal particularly welcomes reviews on current topics of special interest and relevance.

Manuscripts Published

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-PDRS-0000250
Title: Assessment of the antioxidant activity of aqueous extract of Acacia catechu bark: An in vitro and in vivo study
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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Safer antioxidants are essential to prevent the progression of free radical mediated disorders. Plants present a large source of natural antioxidants that might serve as leads for the development of novel drugs. The present study investigates the antioxidant properties of aqueous extract of bark of Acacia catechu in vitro and in vivo. The in vitro tests in diversified fields included total antioxidant activity, scavenging activities for DPPH and H2O2, reducing power and phenolic content. The IC50 values for DPPH and H2O2 scavenging were found to be 177.53 ± 12.35μg/ml and 455.2 ± 15.48 mg/ml respectively. The plant extract reduced the most Fe3+ ions in reducing power estimation. The extract yielded 67.40 ± 0.279 mg/ml gallic acid equivalent phenolic content per 100 mg plant extract. In the in vivo experiments, the extract treatment showed significant increase in the level of superoxide dismutase, catalase, glutathione-S-transferase and reduced glutathione at the dose of 100 and 200mg/kg bwt. The extract showed no toxicity, as the levels of the toxicity marker enzymes were found to be in the normal range. The present study provides evidence that aqueous extract of Acacia catechu bark shows potential antioxidant and free radical scavenging activity which might be due to the presence of phenolic compounds.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-DVD-0000249
Title: Development and validation of a stability-indicating RP-HPLC method for estimation of Ciclopirox olamine in bulk drug and cream formulation
Category: Development and Validation of Drugs
Section: Research Article
Country: India
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A simple, economic, selective, precise, and stability-indicating HPLC method has been developed and validated for estimation of ciclopirox olamine (CPO) both in bulk drug and in cream formulation. Reversed-phase chromatography was performed on a phenomenex C18 column with mobile phase acetonitrile-phosphate buffer 6.5 pH (70:30 v/v) at a flow rate of 1.0 ml min-1. Detection was performed at 305 nm and a sharp peak was obtained for CPO at a retention time of 7.190 ± 0.045 min. The method was validated for accuracy, precision, specificity and selectivity, robustness, detection and quantification limits, and system suitability in accordance with ICH guidelines. Linear regression analysis data for the calibration plot showed there was a good linear relationship between response and concentration in the range 2 - 16 μg ml-1; the regression coefficient was 0.9980 and the linear regression equation was y = 10035x - 20400. The detection (LOD) and quantification (LOQ) limits were found to be 0.005 and 0.01 μg ml-1, respectively. Statistical analysis proved the method was precise, reproducible, selective, specific, and accurate for analysis of CPO. In order to determine whether the analytical method and assay were stability-indicating, CPO cream was stressed under various conditions to conduct forced degradation studies. The wide linearity range, sensitivity, accuracy, short retention time, and simple mobile phase imply the method is suitable for routine quantification of CPO with high precision and accuracy.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-DTBA-0000248
Title: Chitosan-Alginate Drug Loaded Polymer Network for Accelerated Wound Healing
Category: Drug release and biodegrading ability
Section: Research Article
Country: India
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The biodegradable sponge composed of chitosan and sodium alginate at different ratio (1:3, 2:2, 3:1) was prepared and analyzed for their swelling, in vitro drug release and biodegrading ability. Plumbagin a multifunctional agent was incorporated into chitosan and alginate sponge to deter wound infection. The water uptake ability, lysozyme degradation resistance and persistence drug release was found to be more appropriate in the sponge prepared with high ratio of chitosan to alginate. An in vivo animal test employed confirms the applicability of the sponge as a wound dressing material without any adverse symptoms. The sponge had better wound healing effect than cotton gauze and by incorporating plumbagin a more accelerated wound healing was observed in animal model.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-PDRS-0000247
Title: Antioxidant potential of tissue cultured Mentha spicata
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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Environmental pollutants and food contaminants are posing an oxidative stress in humans. The body’s endogenous defenses may not be adequate to prevent the damages completely. So, it is pertinent to look for some exogenous source of natural antioxidants that can be incorporated in the diet to modulate body’s antioxidant defense mechanisms. Herbs can be important sources of natural antioxidants. Keeping this in view, present study had been carried out to evaluate antioxygenic potential of tissue culture raised Mentha spicata (SPR 8). This mentha species was found to be rich in phenolics. Various in vitro models viz. hydroxyl, nitric oxide,super oxide radical scavenging potential, iron reducing power, iron chelation and inhibition of linoleic acid peroxidation revealed Mentha spicata (SPR 8) to be a potent source of antioxidants. Usefulness of Mentha spicata was further proved using ex vivo models involving human erythrocytes. Being rich in iron and PUFA erythrocytes are vulnerable to oxidative damage when exposed to molecular oxygen. Moreover, human erythrocytes when incubated at low temperature tend to lose their endogenous antioxidants. The rate of loss of antioxidant potential in the presence of an extract can therefore be an index of antioxidant potential. The Mentha spicata (SPR 8) extract protected erythrocytes against induced LPO of erythrocytes as well as osmotic fragility over the incubation period of 72 h. Loss of activities of antioxidant enzymes over the incubation period was prevented to a good extent using Mentha extracts. Thus, tissue culture raised Mentha spicata (SPR 8) can be a potent source of antioxidants.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-PP-0000246
Title: Assessment of impact of pregnancy-induce hypertension and patient counseling on pregnancy outcome
Category: Pharmacy Practice
Section: Research Article
Country: India
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A perspective study was conducted in order to assess the impact of pregnancy-induced hypertension (PIH) on pregnancy outcome as well as to assess and improve the knowledge towards PIH among pregnant women by effective patient counseling. Fifty pregnant women were taken up for the study of which 32 women had PIH (classified as Group 1) and the remaining 18 had preeclampsia (classified as Group 2). A suitably designed questionnaire consisting of ten questions were given at baseline to assess patients’ knowledge. Then the patients received counseling and patient information leaflets (PILs). Final follow up was made by administering the questionnaire to patients to assess the improvement in their knowledge. Also the cases were followed up till delivery of the child in order to assess pregnancy outcome. At the final follow up, a considerable improvement in patient’s knowledge was observed in both the groups. In Group 1, 6.25 % of patients experienced preterm labour and in Group 2, 61.1 % of patients experienced preterm labour. Perinatal deaths were seen in 3.1 % of Group 1 and 38.8% were seen with Group 2 patients. And intrauterine growth retardation was observed in 3.1 % of patients in Group 1, and 44.5% of Group 2 patients. With both the groups, counseling made the patients understand better about the disease and therapy and thus enhanced compliance.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-IALI-0000245
Title: Simultaneous estimation of cefixime trihydrate and linezolid in tablet dosage form by derivative spectrophotometric method
Category: Instrumental analysis led to identification
Section: Research Article
Country: India
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Simple, rapid, accurate and precise spectrophotometric method have been developed for simultaneous estimation of Cefixime trihydrate and Linezolid in tablet dosage form. Method involves, formation of ‘1st derivative spectroscopic method’ at 255.3 nm (zeros crossover point of cefixime) and 325.82 nm (zero cross over point of linezolid) using methanol as a solvent. The linearity was observed in the concentration range of 2 - 14 µg /ml for Cefixime trihydrate and 2 - 18 µg/ml for Linezolid. The results of analysis have been validated statistically and by recovery studies and were found satisfactory. Limit of detection for cefixime trihydrate and linezolid were found to be 0.54 µg/ml and 0.77 µg/ml respectively. Limit of quantification for cefixime trihydrate and linezolid were found to be 1.54 µg/ml and 1.67 µg/ml.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-SDCS-0000244
Title: Benzimidazole chalcones: Potent glycosidase inhibitors
Category: Synthetic Drug Chemistry study
Section: Research Article
Country: India
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Benzimidazole-2-substituted chalcones, a new class of glycosidase inhibitors are synthesized using recyclable PEG-400 as an alternative reaction solvent. Effect of synthesized compounds on glycosidase enzymes (α-amylase and glucoamylase) were studied in vitro. Chalcones bearing electron withdrawing groups exhibit strong α-glycosidase inhibitory action whereas electron donating groups displayed moderate inhibitory action. However, nitro derivative of chalcones 3d (IC50 = 1 mM), 3m (IC50 = 2 mM) and 3n (IC50 = 4.9 mM) proved to be potent inhibitors against a-amylase whereas derivative 3h (IC50 = 19 mM) was found to be moderate inhibitor of glucoamylase.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-PDRS-0000243
Title: GC-MS study of phytochemicals in black gram using two different organic manures
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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Plants are excellent source of drugs for the majority of the world population. It is a good challenge for scientists to provide efficient, safe and cheap medications. Black gram can be used as an antioxidant in treating aliments like liver diseases, cancer, diabetes, kidney diseases and for curing microbial infection. The present investigation was carried out to determine the phytochemicals present in the root nodules of Vigna mungo.L which was grown with different types of organic manures. GC-MS analysis led to identification of specific chemical compounds released from plants using two different organic manures which show antimicrobial activity.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-SDCS-0000242
Title: Design synthesis characterization and dual biological activity of some novel morphanthridine 6,11 dione derivatives
Category: Synthetic Drug Chemistry study
Section: Research Article
Country: India
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In modern medicinal chemistry, molecular modeling study is effectively participating in drug discovery process to reduce and the time and cost. The present study involved in the docking of 4-alkylamide/imides substituted 5H morphanthridine 6,11-dione [5H Dibenzo(b,e) apine 6,11-dione] derivatives 1(a-d), 2(a-d), 3(a-d) and 4(a-d) with Mono Amine Oxidase A protein to find out their potency of antidepressant activity. On the basis of docking result the molecules 1a, 2a, 2b, 2c, 3a, 3b, 4a and 4c were synthesized, characterized and evaluated for antidepressant activity by Forced Swim Test. Also all the 12 molecules synthesized characterized and evaluated to their in vitro anti bacterial activity by Agar Plate Disc diffusion method.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-MDSM-0000241
Title: Molecular docking of secondary metabolites from Cyperus rotundus and Cyamopsis tetragonolobus against aldose reductase - A novel drug target for diabetic cataract
Category: Molecular docking of secondary metabolites
Section: Research Article
Country: India
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Diabetic cataract is one of the serious complications of diabetes mellitus, which is a major cause of blindness all over the world. Aldose reductase is the rate limiting enzyme responsible for triggering the pathogenesis of diabetic cataract. Nowadays, natural therapy is gaining more value as alternative medicine. So, it was planned to study the ability of secondary metabolites identified from Cyperus rotundus and Cyamopsis tetragonolobus to serve as antagonist to aldose reductase that may serve as new drug target. 21 compounds were identified as secondary metabolites of ethanolic extract of C. rotundus rhizome by GC-MS analysis and 34 compounds were identified from ethanol extract of C. tetragonolobus fruit. These compounds were docked with aldose reductase. Docking analysis was performed using GLIDE. We describe the docking of these identified compounds into the 3D structure of aldose reductase of human. The inhibitor binding positions and affinity were evaluated using scoring functions. The compounds 3-(2-hydroxy-3,4-dimethoxyphenyl)-7-chromanol and 3-bromo-4-(methoxymethyl)-bicyclo [4.2.0] octa-1,3,5,7-tetraene from C. tetragonolobus were identified as potential inhibitors of aldose reductase. In addition, camphoric aldehyde and longifolenaldehyde from C. rotundus are considered for its effective binding with the target protein. 1,2-cyclopentanedione and (3,8,8-Trimethyl-1,2,3,4,5,6,7,8-octahydro-2-naphthalenyl)methyl acetate showed more hydrogen bond interactions with effective binding to aldose reductase. Thus, it may be concluded that the identified metabolites from both the plants could serve as antagonist to aldose reductase that can be used to treat diabetic cataract.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-Pha-0000240
Title: In-house validation of high fat diet induced obesity models
Category: Pharmacology
Section: Research Article
Country: India
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Background: Obesity results from a prolonged imbalance between energy intake and energy expenditure, as depending on basal metabolic rate, heat production, thermogenic effects of the diet and physical activity. Diet-induced obesity (DIO) in rodents can be achieved by different regimens and approaches. Diets providing a high fat intake have been established as a “gold standard” to generate obese rodent models and have proven to initiate pathologies similar to those encountered in humans. However, this dietary treatment is far from being standardized and its relevance has been criticized on the basis of findings in humans that total energy intake rather than fat per se determines body fat accumulation in humans. Hence, varieties of high fat diet regimens have been introduced by providing a choice of several palatable food items of variable composition, appearance and texture in addition to a non-purified diet. Further male rats have been considered in developing all types of obesity models and no rationale has been provided as of this discrimination and negligence of using female rats. Another pitfall in the obesity model development is that of the choice of the strain of the rats used for the study. The basis on which the specific strain is being chosen still remains controversial. This present study aimed at comparing and validating different diet induced obesity models utilizing different high fat diet regimens in different strains and gender. Methods: Sprague-Dawley and Wistar male and female rats were offered different high fat diet regimens for 7 weeks to induce obesity. Marketed high fat diet group served as a standard. Evaluation parameters like food intake, calorie intake, water intake, % increase in body weight, plasma total cholesterol, HDL-C, LDL-C, VLDL-C, triglyceride, oral glucose tolerance test and insulin tolerance test were performed to assess the efficacy. Results: Diet specific, strain specific and gender specific variation was observed in case of diet induced obesity models. Marketed diet produced better lipid profile and also produced signs of diabetes and thus can be used for obesity-diabetes studies. Vegetable ghee::coconut oil diet produced higher increase in lipid profile in shorter span of dietary manipulation of 4 week and also gave confirmation of equal amount of fat ingested by the entire group. In-house prepared HFD produced better results at the end of 7 week of dietary manipulation. Strain wise Sprague-Dawley rats produced better results and gender wise males showed greater increase in lipid profile than that of females. Conclusions: The results of the study provide clear evidence that vegetable ghee::coconut oil (3:2) diet serves as a better model of hyperlipidemia/obesity as it requires shorter time of dietary manipulation and economically also is more feasible. Marketed diet produced better results but takes longer time to develop and also causes glucose intolerance and insulin resistance thus can serve as a model of obesity and diabetes. Strain wise and gender wise Sprague-Dawley rats and males respectively served as a better model for obesity. The reason for this can be attributed to the metabolic activity as concluded from the calorie intake values that persists in Sprague-Dawley rats and that in males. Further study is required to derive proper conclusions.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-PDRS-0000238
Title: Evaluation of in vitro antioxidant activity of plant Chrozophora plicata
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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Free radical induced oxidative stress is involved in the pathogenesis of various diseases and disorders. Antioxidants are the free radical scavengers which protect human body against the oxidative stress. The present study was carried out to evaluate the in vitro antioxidant properties of 70% ethanol extract of Chrozophora plicata plant (Leaves) by estimation of reducing power and scavenging activity of Superoxide anion, Hydroxyl radical and Nitric oxide anion. The Ethanolic extract of leaves had shown concentration dependent reducing power. This exhibited higher reducing power at 100mg concentration of extract as similar to standard drug (sodium metabisulphite 25mg). Similarly, Ethanolic extract of Chrozophora plicata also have shown concentration dependant superoxide scavenging activity, hydroxyl radical scavenging activity and Nitric oxide radical scavenging activities at 100mg but to a lesser extent than standard drug (sodium metabisulphite 25mg). From the preliminary studies, it was found that the leaves of Chrozophora plicata plant contain triterpenoids and related compounds (sterols, alcohols and hydrocarbons), phenolic compounds (flavonoids, lignans, coumarins, tannins, phenanthrenes, quinones, phenolic acids, etc.) that are possessing antioxidant properties.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-PDRS-0000237
Title: Anti diabetic potential medicinal plants
Category: Plant Drugs Related Study
Section: Review Article
Country: India
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Diabetes mellitus is caused due to deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin produced. It is a global problem and number of those affected is increasing day by day. The plants provide a potential source of hypoglycemic drugs because many plants and plant derived compounds have been used in the treatment of diabetes. Several medicinal plants have found potential use as hypoglycemic in the Indian system of medicines, including ayurveda. Many Indian plants have been investigated for their beneficial use in different types of diabetes and reports occur in numerous scientific journals. This article aims to provide a comprehensive review on various plant species from Indian biosphere and their constituents, which have been shown to display potent hypoglycemic activity. Ayurveda and other Indian literature mention the use of plants in treatment of various human ailments. India has about 45000 plant species and among them, several thousands have been claimed to possess medicinal properties. Research conducted in last few decades on plants mentioned in ancient literature or used traditionally for diabetes have shown anti-diabetic property. Indian plants which are most effective and the most commonly studied in relation to diabetes and their complications are: Allium cepa, Allium sativum, Aloe vera , Cajanus cajan , Coccinia indica , Caesalpinia bonducella ,Ficus bengalenesis , Gymnema sylvestre, Momordica charantia , Ocimum sanctum, Pterocarpus marsupium, Swertia chirayita ,Syzigium cumini, Tinospora cordifolia and Trigonella foenum graecum. Among these we have evaluated M. charantia, Eugenia jambolana, Mucuna pruriens , T. cordifolia , T. foenum graecum, O. sanctum, P. marsupium, Murraya koeingii and Brassica juncea .All plants have shown varying degree of hypoglycemic and anti-hyperglycemic activity.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-SDCS-0000236
Title: Synthesis and in vitro evaluation of novel urea derivatives as ACE inhibitors
Category: Synthetic Drug Chemistry study
Section: Research Article
Country: India
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ACE inhibitors have been proven to be more effective in the treatment the other established anti-hypertensive. ACE inhibition can be achieved by a drug which can bind to the Zinc atom of the metallopeptidase. Ureas are the simplest molecules with a carbonyl group which show a promising tendency to bind to the Zinc atom. A combinatorial library of 31Novel urea derivatives were synthesized and screened for ACE inhibition. Three amines with different electron withdrawing and electron donating substituents were selected and converted to Isocyanates in the first step. The urea linkage was formed by further coupling these three isocyanates with different aliphatic and aromatic amines to form. These compounds were screened for enzyme inhibition on ACE isolated from acetone treated Rat lung powder in the presence of HHL substrate and borate buffer. Absorbance was measured and compared with standard drug Lisinopril at 410nm. In this study three compounds have showed good percentage of ACE inhibition activity.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-MD-0000235
Title: Potential bioactive compound from novel marine actinobacteria associated with antagonistic activity against human pathogens
Category: Marine Drug
Section: Research Article
Country: India
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A total of fifty six marine actinobacteria were isolated from the soil sediment of South Indian coastal region. The isolates were screened for invitro anti-microbial activity study. The anti-microbial screening showed that, three isolates (1, 2 and 18) exhibited potential activity against human pathogens such as Borrelia bargdosferi, Bartonella henselae, Listeria monocytogens, Helicobacter pylori and Camphylobacter jejuni by extracting bioactive compounds using ethyl acetate, acetone and dimethyl sulfoxide (DMSO). Among them, ethyl acetate extracted bioactive compounds from the isolate 1 exhibited virulent activity (18±0.67, 15±0.39, 11±0.75, 16±0.32 and 10±0.10) against all human pathogens than the other solvents and isolates. The partial characterization of the ethyl acetate extract (isolate - 1) by IR (Infra Red) spectra analysis revealed the possible presence of functional groups such as hydroxyl groups, unsaturated fatty acids and amine derivatives compounds in the extract. A unique 16S rRNA gene sequences and phylogenetic analysis provided strong evidence for the three novel actinobacterial strains (1, 2 and 18) namely Streptomyces acrimycini NGP (JX843532), Streptomyces albogriseolus NGP (JX843531), Streptomyces variabilis NGP (JX843530).

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-PDRS-0000234
Title: Isolation and identification of flavonoid glycosides and natural phthalate derivative from the leaves extract of Melothria heterophylla (Lour.) Cogn.
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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Two known flavonoid glycosides (luteolin-7-O-glucoside and apigenin-7-O-glucoside) and phthalate derivative (dioctyl phthalate) were isolated and characterized for the first time from the methanolic leaves extract of Melothria heterophylla (Lour.) Cogn. a well known traditional plant in Mizoram, India for the treatment and management of inflammation, fever, malaria, sprain and pain. The structure of these compounds were established with the aid of spectroscopic methods (UV, Mass, IR, 13C NMR and 1H NMR spectroscopy).

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-PP-0000233
Title: A study on drug-drug interactions in inpatients of general medicine department in a tertiary care teaching hospital
Category: Pharmacy Practice
Section: Research Article
Country: India
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Objective: Many studies have been done on drug interactions in their local hospitals. Drug interactions may lead to an increase or decrease in the beneficial or the adverse effects of the given drugs. We want to know the incidence rate of drug interactions in a tertiary care hospital in Chennai, our hospital setting, so that this data will be useful in creating awareness among the health care professionals. To study the incidence, frequency and severity of drug-drug interactions in patients admitted in General Medicine Department of Sri Ramachandra Hospital, and to create awareness among the health care professionals. Methods:  A prospective observational study was carried out in Inpatient department of General Medicine in a tertiary care teaching hospital. All inpatients of both sex and who were taking at least four or more drugs (polypharmacy) were included in the study. Over dosage cases were excluded from the study. The medications of the patients were analyzed for possible drug interactions by using computerized data base systems. Statistical analysis was done by Pearson correlation and nonparametric correlation to see the relationship between the number of drugs prescribed and the occurrence of pDDIs. Results and Discussion:  425 cases were analyzed. 342 prescriptions were with interactions. pDDIs were identified in about 80.5% of the study subjects. Of 1872 pDDIs, the major interactions were seen in 4.5%, moderate in 75.6% and minor in 19.9% of the patients. Among the DDIs, the majority were of pharmacodynamic (69.5%), followed by pharmacokinetic (23.4%) and unknown (7.1%). Statistical analysis by Pearson correlation and also by Nonparametric correlation (Kendall’s tau) showed that there was an extremely significant linear relationship (r = 0.623, r=0.496) (p<0.0001) between the number of drugs prescribed for a patient and the occurrence of pDDIs. Conclusion: This article will be useful in rationalizing the prescribing pattern by creating awareness among the physicians about the drug interactions. Detection and reporting of DDIs should be done by all health professionals to ensure patient’s safety. The pharmacist participation in the multidisciplinary team can improve the treatment to hospitalized patients and promote drug safety.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-RP-0000232
Title: A literature review on current tropical diseases and the role of Pharmacist in public health with special reference to tropical diseases
Category: Role of Pharmacist
Section: Review Article
Country: India
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Tropical diseases encompass all diseases that occur principally, in this tropic. In practice, the term is often taken to refer to infectious diseases that flourish in hot, humid conditions, such as malaria, leishmaniasis, schistosomiasis, onchocerciasis, lymphatic filariasis, Chagas disease, Leprosy, and dengue etc. The World Health Organization (WHO) is providing technical support to 14 countries with persistent transmission of yaws or where the disease has reemerged as part of a renewed effort to eradicate the disease. Tropical diseases are the most common infections of the world’s poorest people living in Africa, Asia, and the Americas. Occurring predominantly among people who live on below the World Bank poverty figure of US$1.25 per day. These are group of chronic parasitic and related bacterial and viral infections that actually promote poverty because of their impact on child development, pregnancy outcome, and worker productivity. Pharmacists, also known as druggists or chemists, are healthcare professionals who practice in pharmacy, the field of health sciences focusing on safe and effective medication for therapeutic uses of drugs. They are also play an important role during complete eradication of tropical diseases. National strategies for attaining health for all will normally provide for the monitoring of pharmacy manpower development and pharmacy services in the framework of health systems such as prevention and treatment of Tropical diseases. This comprehensive review article is important data base on current tropical diseases and the role of pharmacist in public health with special reference to tropical diseases.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 1.
Article Id: JPRS-DVD-0000231
Title: Development and Validation of UV Spectrophotometric method for estimation of glibenclamide in bulk and pharmaceutical dosage forms
Category: Development and Validation of Drugs
Section: Research Article
Country: India
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A selective, simple, accurate and reproducible spectrophotometric method has been developed for the estimation of Glibenclamide in bulk and pharmaceutical formulation. The drug obeyed the Beer’s law and showed good correlation. It showed absorption maxima at 300nm in methanol. The developed method was validated with respect to linearity, accuracy and precision. The linearity was observed between 10-100ìg/ml having line equation Y=0.0069X + 0.0209 with correlation coefficient of 0.9988. Results of the analysis were validated statistically and by recovery study.