JPR:BioMedRx:An International Journal
ISSN NO: 2321-4988
BioMedRx journal is devoted to the promotion of Bio, Pharma and related disciplines (including medical, Nursing,Paramedical, Clinical   fields).It seeks to foster multi-disciplinary research and collaboration among scientists, pharmaceutical industries and healthcare sector as well as provide a National and international forum for the communication and evaluation of data, methods and opinions in pharmaceutical sciences and related disciplines.The Editor  welcome contributions of field relevance. Although primarily devoted to original research papers, the journal particularly welcomes reviews on current topics of special interest and relevance.

Manuscripts Published

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 11.
Article Id: JPRS-PP-00001081
Title: A Case Study on Zinc Phosphide Poisoning in Tamil Nadu
Category: Pharmacy Practice
Section: Editorial
Country: India
View Article

Zinc Phosphide has a long history of use and remains an important rodentcide for both commensal and select field rodents. Zinc Phosphide (Rodentcide) associated with both accidental and intentional ingestion. Despite its free availability in the Indian market for use to prevent from rat. It is an uncommon poisoning in India with only a single case report described from India. We report single cases of fatal rodentcide poisoning from a tertiary care hospital in the south state of Tamil Nadu, India.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: 11.
Article Id: JPRS-Pha-00001398
Title: Melatonin protects against lead-induced oxidative stress in stomach, duodenum and spleen of male Wistar rats
Category: Pharmacology
Section: Research Article
Country: India
View Article

Environmental or occupational or even accidental exposure to certain heavy metals can cause generation of reactive oxygen species (ROS) which are major causes of various diseases. Our present investigation demonstrates that the oral supplementation of aqueous solution ofmelatonin has the potential to protect against the oxidative stress in stomach, duodenum and spleen induced by sub-chronic exposure of theexperimental rats to the heavy metal , lead (Pb). Rats were intraperitoneally injected with lead acetate (15mg/kg body weight). Another group was pre-treated with melatonin (10 mg / kg, fed orally).The positive control group was fed melatonin (10 mg / kg), and the control animals received vehicle treatment i.p. for 7 consecutive days. The alterations in the activity of the different biomarkers of oxidative stress and the activities of the antioxidant enzymes were studied. Histo-morphological changes in the gastric, duodenal and splenic tissues were studied through H-E staining. Lead caused alterations in all the parameters studied. All these changes were mitigated in all the three tissues when the
rats were pre-treated with melatonin. The results indicate that melatonin protects against lead-induced damages in stomach, duodenum and spleen in experimental rats by antioxidant mechanism. Melatonin may have future therapeutic relevance in the prevention of lead-induced gastro-toxicity as well as in splenic toxicity and duodenal toxicity in humans exposed occupationally or environmentally to this toxic heavy metal and may be used for development of new drug with almost no or minimum side-effect.