JPR:BioMedRx:An International Journal
ISSN NO: 2321-4988
BioMedRx journal is devoted to the promotion of Bio, Pharma and related disciplines (including medical, Nursing,Paramedical, Clinical   fields).It seeks to foster multi-disciplinary research and collaboration among scientists, pharmaceutical industries and healthcare sector as well as provide a National and international forum for the communication and evaluation of data, methods and opinions in pharmaceutical sciences and related disciplines.The Editor  welcome contributions of field relevance. Although primarily devoted to original research papers, the journal particularly welcomes reviews on current topics of special interest and relevance.

Manuscripts Published

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-PDRS-0000270
Title: Comparitive study on phytochemicals from leaves of Mentha piperita (Mint), Psidium guajava (Guava) and Moringa oleifera (Drumstick)
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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Propanolic extract of leaves of three plants namely mint (Mentha piperita), guava (Psidium guajava), drum stick (Moringa oleifera) were prepared separately. Comparison for the presence of some important phytochemicals like, terpenpoids, reducing sugars, tannins, cabonyl, flavonoids, phlobatanins, steroids etc. were studied. It was found that saponins, terpenoids and reducing sugar was present in all the three plant extracts. Carbonyl and flavonoids were present in guava leaves. Moringa leaves exhibited the presence of carbonyl, flavonoids, phlobatanin and steroids. In the mint leaves tannins, carbonyls, flavonoids, phlobatanin and steroids were conspicuous by their absence.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-SDCS-0000269
Title: Synthesis characterization and biological activities of Schiff bases of Isatin
Category: Synthetic Drug Chemistry study
Section: Research Article
Country: India
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In the present study, five new Schiff bases of Isatin were synthesized. These new compounds were formed through the condensation reaction between Isatin with 2-aminobenzoicacid, 4-aminobenzoicacid, urea, thiourea and, Pyridin-2-amine. The synthesized compound structures were characterized by FT-IR and H1NMR spectroscopy. The biological activities of the compounds were predicted by using PASS (online software for bioactivity prediction).The newly synthesized Schiff bases of , (3Z)-3-[(pyridin-2-yl)imino]-2,3-dihydro-1H-indol-2-one has shown twitching activity, Nicotinic alpha2beta2 receptor antagonist and fibrillation atrial activity. 2-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]amino}benzoic acid shows better activity in acute neurological disorder. [(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]thiourea acts as a best Thioredoxin inhibitor.4-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]amino}benzoic acid was found to have hypothermic activity.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-SDCS-0000268
Title: Microwave assisted synthesis, characterization & biological evaluation of 2-(phenoxymethyl)-1-[5-(substituted aryl)-1,3,4-oxadiazole-2-yl]-1H-benzimidazoles
Category: Synthetic Drug Chemistry study
Section: Research Article
Country: India
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In an effort to develop novel 1,3,4-oxadiazoles, with various substituents characterizing and biologically screening them for anticonvulsant and antibacterial activities, a series of benzimidazole containing 1,3,4- oxadiazoles were synthesized by microwave assisted methods from presynthesized acetohydrazide by refluxing them with substituted aromatic acids at appropriate temperature in the suitably designed experimental conditions. The synthesized compounds were characterized by means of their IR, HNMR data, Mass spectrophotometry and elemental analysis. All compounds were tested for their anticonvulsant (using MES method) and antibacterial (against E. coli, S. aureus etc) activities.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-SDCS-0000267
Title: Assay of Some Adreno-corticosteroid Drugs with Pyridinium Fluorochromate Reagent
Category: Synthetic Drug Chemistry study
Section: Research Article
Country: India
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In the present paper, we have reported a simple and convenient titrimetric method for determination of adreno-corticosteroid drugs e.g. betamethasone sodium phosphate, dexamethasone sodium phosphate, hydrocortisone sodium succinate, prednisolone sodium succinate and triamcinolone in pure form and in their pharmaceutical preparations such as betnesol (Inj), cortil (Tab), decdon (Inj), dexasone (Tab), Primacprt (Inj), wycort (Inj), wysolone (Tab), predone forte (Syrup), tricort (Inj) and ledercort (Tab) with pyridinium fluorochromate (PFC) reagent. It is a versatile oxidizing agent of chromium (VI) and it is being increasingly used as an oxidant for several classes of organic compounds. The value of percentage error, coefficient of variation (CV) and standard deviation (SD) prove the method to be precise and reproducible. To establish authenticity of the method, recovery experiments were also carried out by standard drug addition method. It was noted that the excipients present in pharmaceutical preparations do not interfere in the estimation.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-SDCS-0000266
Title: Designing, structural, redox and biological investigation of copper(II), nickel(II), cobalt(II), Zinc(II) and vanadium(IV) complexes derived from 1-phenyl-2,3-dimethyl- 4-imino-(3-oxo-N-phenylbutamide
Category: Synthetic Drug Chemistry study
Section: Research Article
Country: India
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A Schiff base namely tetradentate N2O2 donor has been prepared by condensation of acetoacetaninilido-4-aminoantipyrine and 5-(a-imino)-indole-3-propionic acid (tryptophan) in 1:1 molar ratio. Copper(II), Nickel(II), cobalt(II), Zinc(II) and VO(II) complexes of this Schiff base have been synthesized and characterized by elemental analysis, molar conductance, Magnetic measurements, IR, UV- Vis., 1H- NMR, FAB Mass, and ESR spectral data. The IR data show that the ligand is coordinated to the metal ion in a tetratendate manner with N2O2 donor site of the enolic –OH group, carboxylate oxygen and two azomethine nitrogen. Magnetic measurements and electronic spectral data of the chelates suggested that all the complexes are square planar geometry except VO(II) complex which has square pyramidal geometry. 1H-NMR spectra of the Schiff base and its zinc complex reveal that carboxylate proton of amino acid and enolic hydroxyl proton of acetoacetanilido-4- aminoantipyrine moiety were displaced during complexation. The ligand and the metal complexes were evaluated for antibacterial and antifungal activities against various bacterial and fungal strains. The results showed that all the chelate have better activity than the free ligand.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-PDRS-0000265
Title: Preliminary phytochemical screening and evaluation of antibacterial effect of Amaranthus caudatus
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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Amaranthus caudatus is a medicinal plant belongs to the family Amarannthaceae. The present study was carried out to investigate the phytochemical constituents and assayed for antibacterial effect of this plant. In the phytochemical screening, different types of solvent like ethanol, chloroform, petroleum ether were taken which revealed that the leaves extract of Amaranthus caudatus contain flavonoids, terpenoids, steroids, cardiac glycosides, carbohydrates, tannins, saponins, proteins as secondary metabolites and chemical compounds. The microorganisms assayed for antibacterial activity were against three Gram positive bacteria Listeria monocytogenes, Staphylococcus pyrogenes, Enterococcus faecalis and three Gram negative bacteria Salmonella enterica, Escherichia coli, Pseudomonas aeruginosa The result showed that the leaf extract of Amaranthus caudatus can be used as a good herbal medicine.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-Ph-0000264
Title: Formulation and Physical Characterization of Microcrystals for Dissolution Rate Enhancement of Telmisartan
Category: Pharmaceutics
Section: Research Article
Country: India
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Telmisartan is a potent, long-lasting, nonpeptide antagonist of the angiotensin II type-1(AT1) receptor that is indicated for the treatment of essential hypertension. Telmisartan is practically insoluble in water and its dissolution is the rate-limiting step for its absorption, which leads to variable bioavailability. The aim of this investigation was to enhance the dissolution rate of Telmisartan by formation of microcrystals using solvent change method. The in-situ micronization process was carried out using solvent change method in the presence of Polyvinylpyrrolidone (PVP) as a stabilizing agent that limits the size of the particles generated. Telmisartan was dissolved in methanol and the stabilizing agent in water (as a non-solvent). The non-solvent was poured rapidly into the drug solution under stirring by a magnetic stirrer, and the resultant was oven-dried. Microcrystals were characterized by optical microscopy, SEM, FTIR, XRD and in vitro powder dissolution study. Telmisartan microcrystals showed narrow particle size and change in crystalline shape from avicular shape. FTIR results showed no interaction between the drug and the stabilizer. XRD diffractograms of microcrystals showed smaller peak height than untreated Telmisartan indicates that crystal habit modification occurred in the microcrystals without any polymorphic changes. Negative Gibb’s free energy change represented spontaneous solubility of microcrystals. Dissolution efficiency of Telmisartan microcrystals at 15 min (DE15%) was increased about 9 times. Microcrystals were found to have good flow property.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-PDRS-0000263
Title: Evaluation of Anti-Alzheimer’s properties of Bacopa monniera extract on Morphometric, Behavoural aspects and Cholinergic system in albino mice
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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The aim of the present study is to assess the anti-Alzheimer’s properties of Bacopa monniera plant extract (BME) on the cholinergic system of AD-induced mice. Male albino mice, Mus musculus, of one month old weighing 20±2 grams, obtained from Sri Venkateswara Enterprises, Bangalore were used as the experimental model. They were maintained in the animal house of the Department (Behringer,1973) according to the ethical guidelines for animal protection and welfare bearing the Resolution No. 02/(i)/a/CPCSEA/ IAEC/ SVU/ KY-KK/ Dt. 21-03-2011. The mice were fed with standard pellet diet and water ad libitum. The mice were divided in to four groups as follows: Group I: Control mice; Group II: mice treated with BME; Group III(AD induced): mice treated with D-Gal & NaNO2; Group IV: AD induced mice simultaneously treated with BME. Changes in Morphometric and Behavioural aspects of four groups of mice were analised by using Morris Water Maze technique. Various constituents of the cholinergic system viz., Acetylcholine (ACh) content and Acetylcholinesterase (AChE) activity were determined in selected regions of all groups of mice at selected time intervals through standard biochemical assay methods. From our results, it was ovious that BME showed positive effects on body weight, learning skills, memory and concentration, whereas D-Gal and NaNO2 caused learning and memory deficits in mice which could be ameliorated by simultaneous administration of BME. Similar protective effectsof BME were noticed on the cholinergic system of mice brain wherein , oral administration of BME could revert both the ACh content and also AChE activity to normal levels in AD induced mice. Form these observations on Morphometric and Behavioural aspects and also on the Cholinergic system it was finally concludd that BME had potential compounds which can prevent the learning and memory deficits effectively and thus confer neuroprotection againt Alzheimers Disease.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-Ph-0000262
Title: Solubility enhancement and formulation of rapid disintegrating tablet of Febuxostat Cyclodextrin complex.
Category: Pharmaceutics
Section: Research Article
Country: India
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Febuxostat is a non-purine, xanthine oxidase inhibitor. It is a BCS class II drug. It exhibits poor bioavailability of about 49% which is attributed to its poor solubility. The present work was aimed at overcoming these two limitations. Drug-β-cyclodextrin and Hydroxy propyl â-cyclodextrin complex were prepared and characterized by FTIR, DSC and PXRD studies. Saturation solubility study was carried out to evaluate the increase in the solubility of febuxostat. In vitro studies showed that the solubility and dissolution rate of febuxostat were significantly improved by complexation with β-cyclodextrin and Hydroxy propyl β-cyclodextrin with respect to drug alone. The inclusion complexes with β-CD prepared by spray drying method showed highest solubility (305.09%) and fast dissolution profile while inclusion complexes with HP-β-CD prepared by co-evaporation method showed highest solubility (330.24%) and it was incorporated into rapid disintegrating tablet. The tablets were prepared by using three different superdisintegrants, crosspovidone, sodium starch glycolate and croscarmellose sodium by direct compression. Tablets were evaluated for the hardness, friability, assay, thickness, disintegration time and average weight. Tablets shows enhance dissolution rate as compared to pure febuxostat.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-QSAR-0000261
Title: CoMFA and CoMSIA 3D-QSAR Studies on Phenyl ethanolamine Derivatives as Inhibitors of Staphylococcus aureus Phenylalanyl t-RNA Synthetase.
Category: QSAR Studies
Section: Research Article
Country: India
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With the objective to design new chemical entities with enhanced inhibitory potencies against Phenylalanyl t-RNA Synthetase (PTS), the 3D-QSAR Comparative Molecular Field Analysis (CoMFA) and comparative molecular similarity indices analysis (COMSIA) studies were carried out on Phenyl ethanolamine derivatives compounds. The CoMFA model yielded satisfactory statistical data with the cross-validated q2 value of 0.88 and the non-cross-validated r2 value of 0.986. The cross-validated q2 value for CoMSIA model was 0.75 and the non-cross-validated r2 value was 0.99. The high leave-one-out (LOO) cross-validated correlation coefficient q2 reveals that the model is a useful tool for the prediction of test set of 10 compounds that were not included in the training set of 38 compounds. The results not only lead to better understanding of structural requirements of PTS inhibitors but also can help in the design of new potent inhibitors.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-PDRS-0000260
Title: Efficient adsorption of Pb+2 and Cd+2 from effluents on Eco-Friendly and low cost adsorbent developed from Achyranthes aspera Linn. stem
Category: Plant Drugs Related Study
Section: Editorial
Country: India
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Heavy metals are major toxicants found in industrial wastewater, they adversely affect to the aquatic flora, animals and human beings . In this study, the removal of heavy metals like Pb+2 and Cd+2 from aqueous solution using eco- friendly and low cost activated carbon has been investigated . The carbon is prepared from Achyranthes aspera Linn. stem by treatment with conc. H2SO4. The powdered raw material and chemically treated material of specific micron size is used by employing various temperature. The results revealed that the removal of dye by chemically treated material is more effective than raw material at higher temperature. The experimental data is analyzed using Freundlich and Langmuir isotherm models and it is fit with these isotherm models. The adsorption capacity (Qm) for Pb+2 and Cd+2 is calculated at 25,35 and450C . It is found to be a potential adsorbent for removal of Pb+2 and Cd+2 from effluents.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-PDRS-0000259
Title: Phytochemical Screening and Central Nervous System Activity of Methanolic Extract of Cucumis sativus Leaves.
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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Bioactive plant parts remain popular as therapeutics in all age. Their significance is intensifying day by day to provide safe, affordable and obtainable drugs for all classes of people. The present investigation was designed to evaluate the activity of Cucumis sativus leaves as analgesic and CNS depressant in model mice along with phytochemical screening. The analgesic activity of the extract was examined using acetic acid-induced writhing test (chemically induced pain) and tail immersion test (thermally induced pain) at the dose of 200 and 300 mg/kg body weight. CNS depressant activity was evaluated by pentobarbitone-induced hypnosis, neuropharmacological experiment by open field and hole cross tests at the doses of 200 and 400 mg/kg body weight. The results of the statistical analysis showed that the plant extract had significant (P<0.001) dose dependent CNS depressant and antinociceptive activities. The extract, at the dose of 300mg/kg showed better analgesic effects in tail immersion test, indicating its centrally acting analgesic property and exerted 63.64% inhibition of writhing response in the acetic acid-induced writhing model, which is very close to the reference drug Indomethacin (65.91%). The extract also produced a dose-dependent reduction of the onset and duration of pentobarbitone-induced hypnosis, reduction of locomotor and exploratory activities in the open field, hole cross tests. This analgesic and CNS-depressant activity of the extract might be because of presence of different chemical compounds in it. Altogether, these results suggest that the leaves extract of Cucumis sativus possesses remarkable CNS depressant and analgesic properties.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-PDRS-0000257
Title: In vitro antioxidant potential of stem bark of Prosopis cineraria Linn.
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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The present study was to design and evaluation of antioxidants activity of methanolic extract of Prosopis cineraria (Linn.). Anti-oxidants can neutralize the side effects of free radicals by scavenging or chain breaking (like vitamin A, C, -carotene, etc.) or some other mechanism of action. These antioxidants must be constantly replenished since they are ‘used up’ in the process of neutralizing free radicals. The activity of methanolic extract of stem bark of Prosopis Cineraria Linn.( MPCL) was compared with ascorbic acid as standard 10.52 µg/ml (y = 0.4992x + 101.25, 0.9921) and result is 193.54 µg/ml. Data were compared by student t – test and t- value found to be 112.08 which is considered extremely significant. The results of this study show that the MPCL can be used as easily accessible source of natural antioxidants and as a possible food supplement or in pharmaceutical industry.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-Pha-0000256
Title: Evaluation of anticonvulsant activity of ethanolic extract of Nymphaea alba Linn. (white water lily) and its comparison with phenytoin sodium and sodium valproate in albino rats
Category: Pharmacology
Section: Research Article
Country: India
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Objective: The aim of the present work was to evaluate the anticonvulsant activity of ethanolic extract of Nymphaea alba Linn. in rats. Materials and methods: Anticonvulsant activity of ethanolic extract of Nymphaea alba Linn.(200 and 100mg/kg oral) is evaluated in albino rats both in MES induced artificial seizures by Electroconvulsiometer and Pentylene tetrazole (70mg/kg i.p)induced seizures. Phenytoin sodium and sodium valproate were used as standard drugs for these two methods respectively. All drugs were administered orally one hour before tests. Results: Oral administration of ethanolic extract of Nymphaea alba (200 and 100mg/kg) 1 hour before artificial induction of seizures significantly prevented Tonic hind limb extension (THLE) and also decreased the duration of seizures in MES models and was comparable to phenytoin sodium. In PTZ induced models it showed some protection compared to control but was statistically not significant. Conclusion: Nymphaea alba has significant anticonvulsant property in MES model at the dose of 100 and 200mg/kg and is comparable to phenytoin sodium. But Nymphaea alba did not show statistically significant anticonvulsant property in PTZ induced seizures.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-PDRS-0000255
Title: Analgesic, anti-inflammatory and anti-arthritic activity of Euphorbia thymifolia Linn phytosterol fraction
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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Euphorbia thymifolia Linn. (family Euphorbiaceae) is an annual herb belonging to genus Euphorbia having many medicinal uses. The present study was carried out to evaluate the analgesic, anti-inflammatory and anti-arthritic activity of the phytosterol fraction of E. thymifolia (ETTS). Phytosterol was separated from the petroleum ether extract of dried aerial part, by refluxing with 5% alcoholic KOH for 4 hr followed by filtration. LD50 was calculated as 283 mg kg-1, i.p and a dose level of 20, 30 and 40 mg kg-1 was chosen for in vivo studies. Analgesic activity was evaluated in mice using morphine and naloxone on Hot Plate instrument to assess the involvement of opioid receptor in analgesic activity. Anti-inflammatory and anti-arthritic activity was evaluated against carrageenan induced paw edema and Complete Freund’s Adjuvant induced arthritis in rats by estimating TNF-a and knee joint Histopathology. ETTS showed significant (P < 0.01) increase in hot plate reaction time which was reversed in presence of naloxone. ETTS at 40 mg kg-1 decreased (P < 0.01-0.001) paw volume, arthritic index and TNF-a expression. ETTS showed repair of articular surfaces with small areas of erosion and irregularities with invasion of connective tissue. E. thymifolia total sterol possesses moderate analgesic, and potent anti-inflammatory and anti-arthritic activities at 40 mg kg-1. Centrally acting mechanism may be involved in analgesic response modulating the opioid receptors having morphine like action as the effects of ETTS was blocked by naloxone. ETTS led to marked repair of articular surfaces and reduction of tissue edema and cellular infiltration.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-DVD-0000254
Title: Development and validation of a thin-layer chromatography-densitometric method for the quantitation of Isovanillin from Hemidesmus indicus (Linn.) R.Br., its extracts and marketed formulations
Category: Development and Validation of Drugs
Section: Research Article
Country: India
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A selective, precise, and accurate high-performance thin-layer chromatographic (HPTLC) method has been proposed for the analysis of Hemidesmus indicus and its formulations for isovanillin content. Hemidesmus indicus is a twining shrub and a root of this taxon has been used in folk medicine as well as in ayurvedic and unani preparations. The method employed TLC aluminium plates precoated with silica gel 60 F254 as the stationary phase. Linear ascending development with toluene: ethyl acetate: methanol: acetic acid 7.5: 1.5: 0.5:0.5 (v/v) as the mobile phase was performed at room temperature (25 ± 2ºC) in a twin-trough glass chamber saturated with mobile phase vapour. Compact bands (Rf 0.39 ± 0.02) were obtained for isovanillin in Crude plant materials, Herbal extracts and Formulations. Scanning was performed in absorbance mode at 230nm. Linear regression analysis of the calibration plots showed good linear relationship between peak area and peak height (r2 = 0.9907 ±0.0002) in the concentration range 87-167 ppm. The method was validated for precision, recovery, robustness, specificity, detection and quantification limits. Recovery percentage in the sample found in between 84.14-86.73%. Quantification values of isovanillin in raw materials, extracts and marketed formulations were found to be 0.17%, 0.40% & 0.14% respectively. The developed technique is precise, specific and accurate for checking the purity of H. indicus.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-PDRS-0000253
Title: Anxiolytic and antidepressant activity of Barleria buxifolia Linn
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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Anxiety and Depression are overwhelming mood disorders which account for 15% of the world population.With the drawback of existing treatment the researchers has focused on plant extracts which are having no side effects.Barleria buxifolia (From the family Acanthaceae) is traditionally used in bronchitis and inflammation.The aim of the present study was to investigate the anxiolytic and andepressant activities.An aqueous extract of dried leaves of Barleria buxifolia(AqEOBB) was prepared.The anxiolytic and antidepressant of this aqueous extract has been evaluated by Elevated Plus Maze[EPM] model and Forced Swim Test[FST].The aqueous extract of Barleria buxifolia has shown effect in dose dependent manner.In EPM model the dose of 200mg/kg has shown significant [p<0.01] effect by increasing the number of entries and time spent in open arms when compared to control group indicating anxiolytic activity and in FST by decreasing the duration of immobity.Barleria buxifolia could be the alternative in treatment but further studies are required to evaluate the mechanism by which the anxiolytic and anti-depression activities are shown.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-PDRS-0000252
Title: Removal of Cationic Dye from effluents using Eco-Friendly Adsorbent
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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In the present study, the use of cheap, ecofriendly and abundantly available waste weed as a raw material for producing adsorbent is investigated. Achyranthes aspera Linn. plant is widespread in the world as a weed, which is locally available on road sides and wastelands. The main aim of this study is to investigate the potentiality of Achyranthes aspera Linn stem as an adsorbent for the adsorption of malachite green. The powdered raw material and chemically treated material of specific micron size is used for the removal of the malachite green from aqueous solution. Adsorption capacity is studied by using malachite green as dye at various temperature. The results revealed that the removal of dye by chemically treated material is more effective than raw material at higher temperature. The experimental data is analyzed using Freundlich and Langmuir isotherm models and it is fit with these isotherm models. The adsorption capacities (Qm) are calculated as 27.4, 29.7, 28.3 at 25,35 and450C respectively . It can be useful as low cost, efficient, potential and ecofriendly adsorbent for the treatment of effluents.

Journal: JPR:BioMedRx:An International Journal, Volume: 1, Issue: February
Article Id: JPRS-PDRS-0000251
Title: Medicinal value of croton sparsiflorus fresh leaf and fruit extracts as shown by antibacterial activity
Category: Plant Drugs Related Study
Section: Research Article
Country: India
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Knowledge on plants by the Indigenous people provides an insight to the researchers to screen traditionally used plants for active principles against various human pathogens. Antibacterial study on Croton sparsiflorus fresh leaf and fresh fruit extracts obtained using petroleum ether showed more medicinal value on Staphylococcus aureus and less on Serratia marcescens. In general, Gram-positive bacteria were more susceptible than Gram-negative bacteria. Leaf extract had profound killing effects on bacteria.