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Title: Preparation and Characterization of Pharmaceutical Grade Chitosan And Hydrated Chitosan Gums for Topical Preparations
Category: Development and Validation of Drugs
Section: Research Article
Author Affiliation: Managing Director, Innomono Laboratories Private Limited, India
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The main goal of this work is the preparation and characterization of hydrated gums using chitosan for further formulation and topic applications. To achieve this goal several gums from pharmaceutical quality chitosan of low (Mw= 72.180 g/mol) and medium. (Mw= 103.000 g/mol) molecular weight with a 4% w/w were employed. The prepared hydrated gums were characterized by infrared spectroscopy, scanning electron microscopy andreological analyses. The spectroscopic study shows no great difference between both gums and most of chitosan bands are exhibited. The rheological studies shows that both gums exhibit a non Newtonian flow independent of the time, with pseudoplastic for low molecular weight chitosan and plastic behavior for the medium molecular weight.