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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link 
Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 (Top level : Life Science)
Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
Cites per document 2014 0.607
Cites per document 2015 0.789
Documents Year Value
Uncited documents 2014 206
Uncited documents 2015 174
Cited documents 2014 107
Cited documents 2015 139
  • Author Guidelines
  • Copyright Notice
  • Editorial boad
  • About JPR
  • Archiving
  • Submission Preparation Checklist

    Main Author Guideline

    The Journal publishes reviews, research articles and short communications.

    The scope of the journals is to publish clinical and Pharmaceutical Sciences which include organic, inorganic, analytical chemistry, pharmaceutics, pharmacology, phytochemistry and pharmacognosy, pharmaceutical analysis, pharmaceutical microbiology and biotechnology.

    It is essential that authors prepare their manuscripts according to established specifications. Failure to follow them may result in papers being delayed or rejected. Therefore, contributors are strongly encouraged to read these instructions carefully before preparing a manuscript for submission. The manuscripts should be checked carefully for grammatical errors. All papers are subjected to rapid peer corrections and publish in Online. Types of manuscripts Research papers: Papers should present new experimental studies in elaborate form that constitute a significant contribution to knowledge. Research Papers should not exceed 15 pages. Short communications: Papers are the one that should present new important findings in a brief form,a maximum of 10 pages including illustrations. Review articles : Papers should bring up the most important current topics or present interpretative and critical accounts, but not simple compilation, on subjects of general interest. They should be around 30 or more pages. Manuscripts are accepted on the understanding that the authors have obtained the necessary authority for publication. Manuscripts with multi-authors imply the consent of each of the authors. Submission of an article to JPR is understood to imply that it has not been either published or not being considered for publication elsewhere. Manuscripts should be neatly typed, single-spaced throughout, including tables, graphs, figures ( IN EXCEL FORMAT). Manuscript should be uniform size with at least 1.0 cm margins on all sides. We do not want any hard copy or CD of the Manuscripts. Only complete file should be submitted to the

    Manuscripts preparations Prepare the manuscript in Times New Roman font using a font size of 12. Title shall be in a font size 14, bold face capitals. All section titles in the manuscript shall be in font size 12, bold face capitals. Subtitles in each section shall be in font size 12, bold face lower case. Standard International Units could be used throughout the text. Pages should not be numbered, manuscript should be starting with the title page and the text should be arranged in the following order: Title page, Abstract, Introduction, Materials and Methods, Results, Discussion or Results and Discussion (Figure and Table titles and legends [must be submitted by excel sheet only), Acknowledgements, References (must be in numerical in text as well as references]). Title Page: The title must be as brief as possible, comprehensive and descriptive. Each author must provide their full name including their forenames and surname followed by their address in normal face lower case. The Corresponding Author of the manuscript must be marked with an asterisk, and should be listed first. In addition the corresponding author must include telephone, fax and E-mail address at the bottom left corner of the title page. If any of the co-authors are from different organizations, their addresses too should be mentioned and indicated using numbers after their names. Abstract: Should start on a new page after the title page and should present the reason of the study, the main findings, and principal conclusions, not more than 250 words. All the three categories, Review Articles, Research papers and Short Communications should have an Abstract. Keywords: 3-6 keywords are to be provided by the authors. Introduction: Should start on a new page and should clearly indicate the aim of the study. Novelty statement in work: Materials and Methods: The section Materials and Methods should include concise details on the methodology adopted, sufficient to repeat the experiment. Extracts and/or fractions tested for in vitro or in vivo biological activities should be chemically defined, at least by means of the results of preliminary phytochemical screening. Complete formulation details of all crude drug mixtures and extracts should be mentioned. The plant name should be fully mentioned when cited first, and the authors are asked to add the details regarding its identification, voucher herbarium specimen number and name of the herbarium institution where it has been deposited. The statistical method and the level of significance chosen should be clearly stated. Results : All results presented in tabular or graphical form shall be described in this section. All Tables and figures must have a title and a legend to make them self-explanatory and they should be given numbers. Tables and figures should be typed on separate excel format sheets only have to be submitted. Discussion: should contain a critical review of the results of the study with the support of relevant literature. It can end with brief conclusions. Acknowledgements: All acknowledgments should be typed in one paragraph directly preceding the reference section. References: number should refer to References. Nothing should be italicized.

    Examples: Journals Author (last name) AB (initials), Author BB, Title of Article, Journal name, volume, year, page numbers.:Books: Author AB, Author BB, Author CC, Title of Book, Ed, Vol, Publisher, City, year, page numbers.


  • Review process:

    Papers will usually be acknowledged upon receipt. Author(s) have to submit duly signed Copyright form.


                                                                       COPYRIGHT FORM


    JPR solutions

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    Sub: Submission of an original/short communication/review article/case report with copyright and authorship responsibility.


    Title of Article: (write title of your article here)

    Corresponding author contact Detail:



    I/we certify that I/we have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I/we believe and know the manuscript represents valid and original work and reflects no plagiarism issue. I/we have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my/our authorship been published or is being considered for publication elsewhere. I/we have read and know policy/rule of JPR SOLUTIONS. Authors accept that they are solely responsible for the content of article and not JPR SOLUTIONS. I/we declare that this article has not published anywhere and I/we know that plagiarism article will be deleted even after publication. We certify that all the data collected during the study is presented in this manuscript & no data from the study has been or will be published separately. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if required. I/we give consent for publication in the JPR SOLUTIONS in any media (print, electronic or any other) and transfer copyright to the JPR SOLUTIONS. I further state that there is no conflict of interests among the authors/coauthors regarding publication of this article.

    I/we also agree to the authorship of the article in the following sequence: 

    Author’s name(s)                                                                       Signatures                                    

    1.------------------------------------                                               1.------------------------

    2.------------------------------------                                                2.-----------------------

    3.-----------------------------------                                                3.------------------------

    4.-----------------------------------                                                4.------------------------



    • All authors are required to sign this above copyright form. However, first author & corresponding author may sign on behalf of others in case of non-availability of other authors, after taking consent of all authors/coauthors.
    • No addition, deletion or change in the sequence of authors is allowed at a later stage.

    The editorial decision is final. The editorial board reserves the right to make corrections/revisions aimed at greater clarity or conformity of style.



     Sumita Mukherjee

    ·Prof. Dr. G. Babu, M. Pharm., Ph. D.,Professor & Principal, [Area of Interest: Pharmaceutical Analysis, Natural Products Chemistry] Devaki Amma Memorial College of Pharmacy,Chelembra,Malappuram dist. 673634,Kerala,India.

    ·Dr. Suvardhan Kanchi, [Area of Interest: Analytical Chemistry, Biosensors, Green Synthesis of NPs, Dye Sensitized Solar cells] Department of Chemistry,Durban University of Technology,Durban,South Africa.

    ·Dr. Zhiyong Peng,Department of CardioVascular Sciences,Heart Institute,East Carolina University,115 Heart Dr,Greenville, NC 27834,USA.

    ·Dr. Debasish Bandyopadhyay [Area of Interest:Herbal Antioxidant Drug Study, Calcutta University, Kolkata.

    ·Dr. Ryszard Amarowicz , [ Area of Interest: Phenolic Compound, antioxidants, Chromatography, food analysis, bioactive compd of plant]Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland.

    ·Dr. Y. K . Gupta, Professor and Head,Dept. of Chemistry,B K Birla Institute of Engineering and Technology,CEERI road,Pilani (Rajasthan), India.

    ·Dr. Bishwambhar Mishra , (Assistant Professor, Dept. of Biotechnology, Sreenidhi Institute of Science and Technology,Hyderabad, India)

    ·Dr. Sat Pal Singh Bisht, ( Professor, Dept of Zoology, Kumaun University, Nainital-263002, Uttarakhand, India )

    ·Dr.Mohamed El Houseiny El Sebeay Shams,Head of the Department of Pharmacy Practice,Oman Pharmacy Institute,Ministry of Health, PO Box 1928, Muscat 114, Oman.

    ·Dr. Smaranika Pattnaik, School of Life Sciences, Sambalpur University, Burla 768019, Odisha,India.

    ·Dr. Kondawar M. S.Prof. and Head,Department of Quality Assurance,Appasaheb Birnale college of Pharmacy,South Shivajinagar, Sangli-Miraj road,Sangli - 416416 (MS)India.

    ·Dr. Md. Amirul Islam , Pharmacy Discipline,Khulna University,Khulna-9208, Bangladesh·Prof. Vaithiamanithi Perumal,SAIMS Medical College, Indore,India·Dr. Biswa Mohan Sahoo,HOD & Associate Professor,Dept. of Medicinal Chemistry,Vikas College of Pharmacy,Putrela Road, Vissannapeta, Krishna Dist-521215 ,Andhra Pradesh, India·Dr. Popat Mohite.Associate Professor, Dapartment of Pharmaceutical Chemistry, MES's College of Pharmacy, SonaiTal- Newasa Dist-Ahmednagar, Maharashtra-414105·Dr.M.Swaroopa, UGC Post Doctoral Fellow in Biomedicine, Division of Zoology, Sri Padmavati Mahila Visvavidyalayam, Tirupati,A.P,India·Dr. Jiafeng Geng, School of Chemistry and Biochemistry, Georgia Institute of Technology, 315 Ferst Dr, Atlanta, GA 30332,  United States·Dr. M. V. Kumudhavalli., [Area of Interest: Phytochemistry and Pharmacology] Dept. of Pharmaceutical Analysis,Vinayaka Mission’s College of Pharmacy, Yercaud Main Road, Kondappanaikenpatty, Salem- 636008, T.N, India·Dr.Rajkumar Venkatadri [ area of Interest: Cancer Research, Pharmaceutical Sciences, Molecular Biology, Drug Invention], Department of Pharmaceutical Sciences, School of Pharmacy, Hampton University, 100 E Queen St, Hampt, VA 23668, USA·Dr. Pankaj  Goyal, Amity Institute of Microbial Technology, Amity University, Noida, Sec-125, India·Dr. Bao Yang, PhD, Professor, [Area of Interest: Botany, enzyme ,bioactive compounds] South China Botanical Garden (Formerly South China Institute of Botany), Chinese Academy of Sciences, Guangzhou 510650, China.Dr. Appala Raju. Nemala, [Area of Interest: Pharmaceutical Analysis] , Department of Pharmaceutical Chemistry,8-2-249, Mount Pleasant, Road#3, Banjara Hills,Sultan-ul-Uloom College of Pharmacy, Hyderabad, Telanagana State. India

    ·Dr. Goutam Kumar Jana,Department of Pharmacognosy,Gayatri College of Pharmacy,At- Gayatri Vihar, PO- Jamadarpali, Via- Sason,Dist- Sambalpur, Pin- 768200, OrissaIndia

    ·Dr. Bhushankumar Suresh Sathe ,[Area of Interest: Pharmacy,Medicinal Chemistry], Department of Pharmaceutical Chemistry, MGSM’S Smt. Sharadchandrika Suresh Patil, College of Pharmacy,Chopda-425107, M.H., India

    ·Dr. Versha Parcha,[Area of Interest: Natural products and Drug Discovery] Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences and Research,Balawala,  Dehradun,  Uttarakhand, India

    ·Dr.Tareeka Dilip Sonawane,[Area of Interest: Biotechnology and Bioinformatics (Reproductive toxicity, Molecular Biology)] D.Y.Patil University ,School of Biotechnology and Bioinformatics Level 5 , Sector 15, Plot No. 50 ,  CBD Belapur, Navi Mumbai  400 614,Maharashtra  India

    ·Dr. Sabyasachi Maiti, [Area of Interest: Pharmaceutics (Novel Drug Delivery, Pharmacokinetics, Biopolymer Hydrogels)], Gupta College of Technological Sciences, Ashram More, GT Road, Asansol-713301, West Bengal, India

    ·Raghunath Singh,Senior Research Fellow (PhD Scholar), [Area of Interest: Nueropsychopharmacology, Ethnopharmacology, Inflammation, Neurodegenerative disorders]  University Institute of Pharmaceutical SciencesUGC-Center of Advanced Study (UGC-CAS),Panjab University,Chandigarh-160014,India

    ·Mohammed Rageeb Mohammed Usman, [Area of Interest: Pharmacognosy] ,Dept. of Pharmacognosy, Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda 425107, Dist - Jalgaon Maharshtra, India.

    ·Dr. Durgacharan Arun Bhagwat, [Area of Interest: Pharmaceutics (Development of Novel Drug Delivery System)],  Dept of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Pin: 416 013, M.S. India.

    ·Dr.. Abhishek Laxminarayan Sharma, Q.A./ Q.C. Manager- Ayurvedic Section; Choksi Laboratories Limited; Vapi,India

    ·Dr. Agnimitra Dinda,[Area of Interest: Pharmaceutics ], Dept of Pharmaceutics, Gyana Jyothi College of Pharmacy,7-48/1, Gyana Jyothi Nagar,Uppal Bus Depot,Hyderabad-98,India

    ·Dr. A. Sai Ramesh, M.S. (by Research), Ph.D.,[Area of Interest: Medicinal Biochemistry, Natural Products, Medicinal Plants] Assistant Professor, Department of Biotechnology,Sree Sastha Institute of Engineering and Technology, Chemberambakkam, Chennai 600123, Tamil Nadu,India.

    ·Dr. Renu Sankar, Postdoctoral Researcher, [Area of Interest: Nanobiotechnology],Biomolecular Therapeutics Laboratory, Department of Chemistry, Sungkyunkwan University, Suwon, 440-746, South Korea.

    Dr. Shashikant  V. Bhandari.[Area of Interest: Drug design and development , Molecular modeling studies viz. QSAR, Anti-cancer], Professor, Head, Department of Pharmaceutical Chemistry, AISSMS College of pharmacy,  Near RTO Office , Kenedy Road, Pune-4110001 ,M.H.,India.

    Dr. Dhavalkumar V Patel, [Area of Interest: Pharmaceutics ] B K Mody Govt Pharmacy College,NR AJI DAM,Polytechnic Campus,Rajkot-360003, Gujarat,India.

    ·Mr. Mayank Sharma, Doctoral Research Fellow, [Area of Interest:  Pharmaceutics(Drug Delivery, Nanotechnology) Department of Pharmaceutics, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore (M.P.) – 452001, India

    Dr.Senthil Venkatachalam , Pharmaceutics [Area of Interest:Muco/Bioadhesive drug delivery system, Nanostructured Lipid carrier system], JSS College of Pharmacy, Rocklands, Ooty, Tamil Nadu 643001,India.

    Dr. M.R Jayapal, [Area of Interest:Organic chemistry,Analytical chemistry,Nanotechnology]Dept of Chemistry, National University of Cordoba,Argentina.

    Dr. Quan Wang,[ Area of Interest : fluorescence spectroscopy, single-molecule detection, biophysics, microfluidics, optics] Department of Chemistry, Stanford University, MC5080,USA.

    Dr. Gopal LalKhatik M.S. Pharm.; Ph.D., Dept. of Pharmaceutical chemistry, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara, Punjab (INDIA) -144411

    Advisory Board:

    ·Dr. Fengguo Xu,Dept of Epidemiology and Public Health,Yong Loo Lin School of Medicine,National University of Singapore,MD3, 16 Medical Drive, Singapore 117600.

    ·Dr. D. Nagasamy Venketash,Dept of Pharmaceutics,JSS College of Pharmacy,Ooty - 643 001. Tamil Nadu. India.

    ·Dr. G.S. Lavekar, Former DG, CCRAS – AYUSH (Govt. of India)

    ·Dr. Debasish Bandyopadhyay ( Calcutta University, Kolkata)

    ·Dr. Vijay Dhondiram Wagh, Pharmaceutical Technology, India

    ·Dr. Ramdas Bhanudas Pandhare[Area of Interest: Pharmacology], University of Pune, India

    ·Dr. Faiyaz Ahamed, India

    ·Dr. Shete R.V, India

    ·Dr. Ramesh Putheti, United States

    ·Dr. Yuanxiong Deng, China

    ·Dr. Praveen Bansal, India

    ·Dr. C. Rajasekaran, India

    ·Dr. A. K. Meena, (NIAPR, Patiala) India

    · Dr. Jongwha Chang, USA 

    · Dr. Somasekhar Penumajji, South Korea

    ·Dr. Geetha Kodali,Mexico

    Dr. Damayanthi Dalu,M.Pharm., Ph.D,Assoc.Professor,Dept.of Pharmacology, Pulla Reddy Institute of Pharmacy,Hyderabad,India

     [ Join the Editorial board by sending brief biodata mail OR Register  in login page : ]

  • The Journal of Pharmacy Research 

    JPR seeks to foster multi-disciplinary research and collaboration among scientists, pharmaceutical industries and healthcare sector as well as provide a National and international forum for the communication and evaluation of data, methods and opinions in pharmaceutical sciences and related disciplines. The Editor  welcome contributions of field relevance. Although primarily devoted to original research papers, the journal particularly welcomes reviews on current topics of special interest and relevance.

    All manuscripts will be subjected to rapid peer corrections and publish. Those of high quality (not previously published and not already under consideration for publication) will be published. All published article text can also be modified with new idea ( only by corresponding authors ) and republish new article and modified article should contain the old article reference in reference section and also after KEY WORDS mentioned [Modification applied ];  in that section author has to describe what  modification done in new article. This modified article will appear in current issue. ( This Open Evaluation Type apply only when editorial will get proper justification from corresponding author to do the modification in article and as we all know the research is a continuous process so need modification with time and this process can save the time and energy and readers can get new idea from one place.

    The  Journal of Pharmacy Research  allowing online submission of manuscripts.  Author should therefore submit and monitor the status of their manuscripts online .


     Journals provides immediate  access  to its content on the principle that making research available to the public supports a greater global exchange of knowledge, meaning:

    • Everymember has access to the full-text of articles published in JPR Solutions Journals; manuscripts are available to the readers without subscription, always suggestion, comments are welcome .
    • Papers are  released in various format


  •    Impact Factor TM ( India ) of JPR. 2.95 as on date (02.01.2017) Authors can use these sites to for more visibility of their articles 






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  • As part of the submission process, authors are required to check off their submission's compliance with all of the following items, and submissions may be returned to authors that do not adhere to these guidelines.

    1. Journal of Pharmacy Research ( ISSN (ONLINE ) : 0974-6943 As part of the submission process, authors are required to check off their submission's compliance with all of the following items, and submissions may be returned to authors that do not adhere to these guidelines.
    • The submission (Research or Review etc.) has not been previously published elsewhere, is original and has been written by the stated authors.
    • The article is not currently being considered for publication by any other journal and will not be submitted for such review while under review by JPR
    • The submission file is in Microsoft Word file (2003 or 2000 format).All Tables and figures in Excel format only
    • Table number ,figure number should be placed within the text at the appropriate points rather than at the end.
    • Figures should be always original. if copied then proper citation must be placed bellow the figures.
    • Corresponding authors E-mail,Mobile number and full address must be given at the first page of article.
    • Copyright must be signed by all authors and submitted along with article.
    • Do not copy of 10 words at a stretch many words or paragraph from other author published work.
    • Work should be novel and full of novel informations
    • References given in text should be superscript with numerical .
    • Article Should be arrange like the following

    Title: Development and Validation of a RP-HPLC Method for Simultaneous Densitometric Analysis ------

    Authors: A.B. Mukherjee1, S. A. Gupta*1 and K. Kumar2------------------

    Affiliations:1Asian University ,Department of Pharmaceutical Sciences, Indian College of Science, Pune – 411038,Maharastra, India. Address for corresponding author: A.B. Mukherjee Asian University ,Department of Pharmaceutical Sciences, Indian College of Science, Pune – 411038,Maharastra, India. E-mail: Phone:



    INTRODUCTION G. acid is a group of triterpenoid saponins isolated from Gymnema sylvestre which is responsible for its anti-diabetic action1. G-------- basic hydrolysis2. -------------------ene3. 18β-Glycyrrhetinic acid is ----------------------- induced diabetic rats4. Extensive literature survey ------------t few HPTLC5, 6, 7 and HPLC2 methods have been reported for estimation of gymnemagenin. HPTLC8. 9, 10 and HPLC11, 12 methods have---------------------- compounds. To the best of our knowledge no reports were found for simultaneous estimation of gymnemagenin and 18β-glycyrrhetinic acid by HPTLC method. ------------------------- in UV regions5. It is therefore necessary to develop methods for rapid, precise ----------------- and inherent quality13, 14. HPTLC is most widely used at industrial level for routine analysis of herbal medicines15. Hence the objective of this work was to develop ------------------------ herbal drug formulation.

    MATERIALS AND METHODS Solvents and chemicals Instrumentation and Chromatographic Conditions RESULTS AND DISCUSSION: HPTLC Method optimization ( table 1,2,3, and fig.1.2.3. ) legends of table and fig has to be given above the table and fig.



    REFERENCES: for Journal:

    1. Chatterjee SE, Shinha AA, Lankota A, Bpahed S, Gymnema Sylvestre: A Comprehensive Review, Drug Invention Today, 2010, 2,144-157. BOOK:

    2.ICH Harmonised Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2 (R1), Nov. 2005.

    3. ---- 40. ----------------------------------------------- once you will finish the preparation then submit the article


Recent Manuscripts published

Journal: Journal of Pharmacy Research

Title: Essential Oil Extraction, Characterization and Anti microbial study of Cythocline purpurea from Konkan Region
Section: Research Article
Category: Natural Drugs
Country: India
View Article

Objective: The present study of was designed to evaluate the methods of essential oil, phytochemical composition and Anti Microbial Study of essential oil from Cythocline purpurea DC collected from Bhramhanwadi, Taluka Dapoli District Ratnagiri in Konkan Region. Methods: The Essential Oil was extracted by Hydro distillation using Clevenger’s type Apparatus and characterization of essential oil was done by IR, GC-MS, GC-FID and Anti Microbial Activity. Results: Total 32 compounds were identified using Gas Chromatography with Mass Spectroscopy. The main components of essential oil are 4- hexen-1-ol, 5-methyl-2-(1-methylethenyl) (70.2%), 1,6 octadiene 3-ol, 3,7-dimethyl (39.9), Phenol, 2-methyl-5- (1-methylethenyl) (42.2%), etc. GC-FID shows number of components of present essential oil. IR confirms the identification of components. Chemical Investigation were done to determine its molecular formula and structure.

Journal: Journal of Pharmacy Research

Title: Synthesis, biological evaluation and molecular docking studies of furo[3,2-H]quinoline-2-carbimidates
Section: Research Article
Category: Pharmaceutical Chemistry
Country: India
View Article

An operationally simple and efficient protocol for the construction of quinoline fused dihydrofuran derivatives 3(a-h) has been achieved via a sequential addition of N-chloro succinimide and base to pyrano[3,2-h]carbonitrile derivatives in alcohol medium. Tandem oxidative difunctionalization was accomplished with N-chloro succinimide reagent by the addition of both chlorine and alkoxy groups across the chromene double bond. Further addition of piperidine base results in the formation of dihydrofuran derivatives by ring contraction. The structures of synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and elemental analysis.The synthesized compounds were evaluated for in vitro antibacterial and cytotoxic activity studies. Further these compounds were screened for computational molecular docking studies against vascular epidermal growth factor receptor tyrosine kinase. Anti bacterial activity results showed that compounds 2g, 2h, 3c, 3d, 3e, 3f and 3h were active against all the four strains of bacteria and their MIC ranged between 1.56 and 12.55 µg/mL. Cytotoxic activity studies revealed that compounds, 2f, and 3b exhibited significant percentage inhibition in cell proliferation at an IC50 value of 4.54 µg/ml and 7.75 µg/ml as well as in silico docking studies also reveal that compounds 2f, 2h, 3b & 3e have good dock score, binding affinity and binding energies towards epidermal growth factor receptor tyrosine kinase.

Journal: Journal of Pharmacy Research

Title: Influences of the methanol extract of the leaves of Anacardium occidentale on selected oxidative stress indices of indomethacin-ulcerated rats
Section: Research Article
Category: Pharmacology
Country: India
View Article

Background and Aim: Researches into medicinal plants with potent anti-oxidant activity will continue to receive the attention of researchers due to the role of oxidative stress in many disease conditions and hence, this study was aimed at investigating the influences of the methanol extract of the leaves of A. occidentale on selected oxidative stress indices of indomethacin-ulcerated rats. Methods: The effects of the methanol extract of the leaves of A. occidentale on the activity of superoxide dismutase (SOD), concentrations of reduced glutathione (GSH) and malondialdehyde (MDA) were evaluated using standard methods. Results: The extract at the administered doses (100, 200 and 400 mg/kg b.w), caused significant (p < 0.05) and dose-related increases in the activities and amounts of SOD and GSH respectively in the rats of the test groups compared to those of the rats in the ulcer-untreated group. The extract treatment also led to significant (p < 0.05) reductions in the concentrations of MDA in the rats of the test groups compared to that of the rats in the ulcer-untreated group. The 400 mg/kg b.w of the extract exerted the greatest effects which were analogous to those of the standard anti-ulcer drug, famotidine at the dose of 50 mg/kg b.w. Conclusion: The methanol extract of the leaves of A. occidentale remarkably ameliorated the gastric ulcer-associated indices in the ulcerated rats and these findings thus support the local application of the leaves of the plant in the treatment of gastric ulcer.