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Journal of Pharmacy Research
ISSN NO: 0974-6943
The Journal of Pharmacy Research is an online Journal, publishing of correct version and document can be modified when, we/or author get comments from any readers. The journal is devoted to the promotion of Pharmaceutical sciences and related disciplines (including Pharmacy, medical, Biotech, Botany, organic and medicinal chemistry,  Nursing, Paramedical, prescription etc  fields).
Scopus Indexed (link http://www.scimagojr.com/journalsearch.php?q=21100325431&tip=sid&clean=0) 
Journal Metrics for this Journal of Pharmacy Research (Source ID: 21100325431): 2015(SNIP) Source Normalized Impact Per Paper : 0.575; SCImago Journal Rank (SJR):0.787; Impact Per Publication : 0.789 (Top level : Life Science)
Year SJR Cites per document Year Value
2014 0.607 Cites / Doc. (4 years) 2014 0.607
2015 0.787 Cites / Doc. (4 years) 2015 0.789
    Cites / Doc. (3 years) 2014 0.607
    Cites / Doc. (3 years) 2015 0.789
    Cites / Doc. (2 years) 2014 0.607
    Cites / Doc. (2 years) 2015 0.789
Cites Year Value
External Cites per document 2014 0.607
External Cites per document 2015 0.789
Cites per document 2014 0.607
Cites per document 2015 0.789
Documents Year Value
Uncited documents 2014 206
Uncited documents 2015 174
Cited documents 2014 107
Cited documents 2015 139
  • Author Guidelines
  • Submission Preparation Checklist
  • Archiving
  • About JPR
  • Editorial boad
  • Copyright Notice
  • Main Author Guideline

    The Journal publishes reviews, research articles and short communications.

    The scope of the journals is to publish clinical and Pharmaceutical Sciences which include organic, inorganic, analytical chemistry, pharmaceutics, pharmacology, phytochemistry and pharmacognosy, pharmaceutical analysis, pharmaceutical microbiology and biotechnology.

    It is essential that authors prepare their manuscripts according to established specifications. Failure to follow them may result in papers being delayed or rejected. Therefore, contributors are strongly encouraged to read these instructions carefully before preparing a manuscript for submission. The manuscripts should be checked carefully for grammatical errors. All papers are subjected to rapid peer corrections and publish in Online. Types of manuscripts Research papers: Papers should present new experimental studies in elaborate form that constitute a significant contribution to knowledge. Research Papers should not exceed 15 pages. Short communications: Papers are the one that should present new important findings in a brief form,a maximum of 10 pages including illustrations. Review articles : Papers should bring up the most important current topics or present interpretative and critical accounts, but not simple compilation, on subjects of general interest. They should be around 30 or more pages. Manuscripts are accepted on the understanding that the authors have obtained the necessary authority for publication. Manuscripts with multi-authors imply the consent of each of the authors. Submission of an article to JPR is understood to imply that it has not been either published or not being considered for publication elsewhere. Manuscripts should be neatly typed, single-spaced throughout, including tables, graphs, figures ( IN EXCEL FORMAT). Manuscript should be uniform size with at least 1.0 cm margins on all sides. We do not want any hard copy or CD of the Manuscripts. Only complete file should be submitted to the e-mail:editorparial@gmail.com

    Manuscripts preparations Prepare the manuscript in Times New Roman font using a font size of 12. Title shall be in a font size 14, bold face capitals. All section titles in the manuscript shall be in font size 12, bold face capitals. Subtitles in each section shall be in font size 12, bold face lower case. Standard International Units could be used throughout the text. Pages should not be numbered, manuscript should be starting with the title page and the text should be arranged in the following order: Title page, Abstract, Introduction, Materials and Methods, Results, Discussion or Results and Discussion (Figure and Table titles and legends [must be submitted by excel sheet only), Acknowledgements, References (must be in numerical in text as well as references]). Title Page: The title must be as brief as possible, comprehensive and descriptive. Each author must provide their full name including their forenames and surname followed by their address in normal face lower case. The Corresponding Author of the manuscript must be marked with an asterisk, and should be listed first. In addition the corresponding author must include telephone, fax and E-mail address at the bottom left corner of the title page. If any of the co-authors are from different organizations, their addresses too should be mentioned and indicated using numbers after their names. Abstract: Should start on a new page after the title page and should present the reason of the study, the main findings, and principal conclusions, not more than 250 words. All the three categories, Review Articles, Research papers and Short Communications should have an Abstract. Keywords: 3-6 keywords are to be provided by the authors. Introduction: Should start on a new page and should clearly indicate the aim of the study. Novelty statement in work: Materials and Methods: The section Materials and Methods should include concise details on the methodology adopted, sufficient to repeat the experiment. Extracts and/or fractions tested for in vitro or in vivo biological activities should be chemically defined, at least by means of the results of preliminary phytochemical screening. Complete formulation details of all crude drug mixtures and extracts should be mentioned. The plant name should be fully mentioned when cited first, and the authors are asked to add the details regarding its identification, voucher herbarium specimen number and name of the herbarium institution where it has been deposited. The statistical method and the level of significance chosen should be clearly stated. Results : All results presented in tabular or graphical form shall be described in this section. All Tables and figures must have a title and a legend to make them self-explanatory and they should be given numbers. Tables and figures should be typed on separate excel format sheets only have to be submitted. Discussion: should contain a critical review of the results of the study with the support of relevant literature. It can end with brief conclusions. Acknowledgements: All acknowledgments should be typed in one paragraph directly preceding the reference section. References: number should refer to References. Nothing should be italicized.

    Examples: Journals Author (last name) AB (initials), Author BB, Title of Article, Journal name, volume, year, page numbers.:Books: Author AB, Author BB, Author CC, Title of Book, Ed, Vol, Publisher, City, year, page numbers.

  • As part of the submission process, authors are required to check off their submission's compliance with all of the following items, and submissions may be returned to authors that do not adhere to these guidelines.

    1. Journal of Pharmacy Research ( ISSN (ONLINE ) : 0974-6943 As part of the submission process, authors are required to check off their submission's compliance with all of the following items, and submissions may be returned to authors that do not adhere to these guidelines.
    • The submission (Research or Review etc.) has not been previously published elsewhere, is original and has been written by the stated authors.
    • The article is not currently being considered for publication by any other journal and will not be submitted for such review while under review by JPR
    • The submission file is in Microsoft Word file (2003 or 2000 format).All Tables and figures in Excel format only
    • Table number ,figure number should be placed within the text at the appropriate points rather than at the end.
    • Figures should be always original. if copied then proper citation must be placed bellow the figures.
    • Corresponding authors E-mail,Mobile number and full address must be given at the first page of article.
    • Copyright must be signed by all authors and submitted along with article.
    • Do not copy of 10 words at a stretch many words or paragraph from other author published work.
    • Work should be novel and full of novel informations
    • References given in text should be superscript with numerical .
    • Article Should be arrange like the following

    Title: Development and Validation of a RP-HPLC Method for Simultaneous Densitometric Analysis ------

    Authors: A.B. Mukherjee1, S. A. Gupta*1 and K. Kumar2------------------

    Affiliations:1Asian University ,Department of Pharmaceutical Sciences, Indian College of Science, Pune – 411038,Maharastra, India. Address for corresponding author: A.B. Mukherjee Asian University ,Department of Pharmaceutical Sciences, Indian College of Science, Pune – 411038,Maharastra, India. E-mail: Phone:

    ABSTRACT

    Keywords:

    INTRODUCTION G. acid is a group of triterpenoid saponins isolated from Gymnema sylvestre which is responsible for its anti-diabetic action1. G-------- basic hydrolysis2. -------------------ene3. 18β-Glycyrrhetinic acid is ----------------------- induced diabetic rats4. Extensive literature survey ------------t few HPTLC5, 6, 7 and HPLC2 methods have been reported for estimation of gymnemagenin. HPTLC8. 9, 10 and HPLC11, 12 methods have---------------------- compounds. To the best of our knowledge no reports were found for simultaneous estimation of gymnemagenin and 18β-glycyrrhetinic acid by HPTLC method. ------------------------- in UV regions5. It is therefore necessary to develop methods for rapid, precise ----------------- and inherent quality13, 14. HPTLC is most widely used at industrial level for routine analysis of herbal medicines15. Hence the objective of this work was to develop ------------------------ herbal drug formulation.

    MATERIALS AND METHODS Solvents and chemicals Instrumentation and Chromatographic Conditions RESULTS AND DISCUSSION: HPTLC Method optimization ( table 1,2,3, and fig.1.2.3. ) legends of table and fig has to be given above the table and fig.

    CONCLUSION:

    ACKNOWLEDGEMENTS:

    REFERENCES: for Journal:

    1. Chatterjee SE, Shinha AA, Lankota A, Bpahed S, Gymnema Sylvestre: A Comprehensive Review, Drug Invention Today, 2010, 2,144-157. BOOK:

    2.ICH Harmonised Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2 (R1), Nov. 2005.

    3. ---- 40. ----------------------------------------------- once you will finish the preparation then submit the article

     

  •    Impact Factor TM ( India ) of JPR. 2.95 as on date (02.01.2017) Authors can use these sites to for more visibility of their articles 

    A https://www.mendeley.com/

    B https://scholar.google.co.in/citations?user=Z6hTSYYAAAAJ&hl=en

    C. http://www.researchgate.net

    D. https://www.academia.edu

    E. http://www.webcitation.org/archive.php ( free for authors)

    F. http://www.authorcite.com/  ( free for authors)

    G. CAS[ American Chemical Society] Source Index (CASSI)   CODEN : JPROFW

    H. Embase Content - Active Embase journal titles [SL number 5068] Elsevier

    I. https://www.ebscohost.com/title-lists

    Está en una o más bases multidisciplinares (Academic Search Premier) = +3
    Está en una o más bases de citas WoS/Scopus (Scopus) = +3.5
    ICDS = 6.500 - See more at: http://miar.ub.edu/issn/0974-6943#sthash.5twphomX.dpuf

    Indexing: 1. Indian citation Index        

    1. a . http://asian-education-index.com/business-directory/journal-of-pharmacy-resarch/

    http://www.ncbi.nlm.nih.gov/nlmcatalog/101556893

    www.cabdirect.org/abstracts/20103127133.html

    http://www.cabdirect.org/subject/ss200/non-food-non-feed-plant-products.html?start=102700

    http://www.gfmer.ch/Medical_journals/Pharmacology_pharmacy.htm [ Search by title ] http://www.jdb.uzh.ch/25259/ [ University of Zurich]

    http://www.researchgate.net [ with few articles by only corresponding authors ]

    http://rzblx1.uni-regensburg.de/ezeit/detail.phtml?bibid=WZB&colors=3&lang=en&jour_id=239647

    http://www.worldcat.org/title/journal-of-pharmacy-research/oclc/495994270 https://www.academia.edu/hiring [ authors can play same role as Researchgate in this site] Like this article [http://www.academia.edu/7871320/Method_Development_and_Validation_for_Simultaneous_Estimation_of_Pantoprazole_and_Domperidone_in_Pharmaceutical_Dosage_Form_M._Sumithra_V.Ravichandiran_Divya_dammayi_P.Shanmugasundaram_A.S.K.Sankar] http://journaldatabase.info/journal/issn0974-6943 [Academic Journals Database] http://ayushportal.nic.in/srchjrnl.aspx [ Many AYUSH related article , AYUSH , Govt of India] Ebscohost] Item Type: Library Index]    

    14. http://umpir.ump.edu.my/view/type/article.html[Universiti Malaysia Pahang]    

    15. http://www.dondelopublico.com/ficha/0974-6943    

    16. http://repository.gsi.de/record/110315    

    17. http://juser.fz-juelich.de/record/204327            

    18.http://journals.indexcopernicus.com/Journal+of+Pharmacy+Research+,p4396,6.html 19. http://www.dondelopublico.com/ficha/0974-6943   Go to pages  https://www.facebook.com/groups/JPRSolutions/ (JPR solutions group )

    20. http://journalseek.net/cgi-bin/journalseek/journalsearch.cgi?query=0974 6943&field=title&editorID=&send=Search+Title%2FISSN+Only

    21. http://www.refseek.com ( Search journal articles)

    SCImago Journal & Country Rank    

    http://www.refseek.com/#
  • The Journal of Pharmacy Research 

    JPR seeks to foster multi-disciplinary research and collaboration among scientists, pharmaceutical industries and healthcare sector as well as provide a National and international forum for the communication and evaluation of data, methods and opinions in pharmaceutical sciences and related disciplines. The Editor  welcome contributions of field relevance. Although primarily devoted to original research papers, the journal particularly welcomes reviews on current topics of special interest and relevance.

    All manuscripts will be subjected to rapid peer corrections and publish. Those of high quality (not previously published and not already under consideration for publication) will be published. All published article text can also be modified with new idea ( only by corresponding authors ) and republish new article and modified article should contain the old article reference in reference section and also after KEY WORDS mentioned [Modification applied ];  in that section author has to describe what  modification done in new article. This modified article will appear in current issue. ( This Open Evaluation Type apply only when editorial will get proper justification from corresponding author to do the modification in article and as we all know the research is a continuous process so need modification with time and this process can save the time and energy and readers can get new idea from one place.

    The  Journal of Pharmacy Research  allowing online submission of manuscripts.  Author should therefore submit and monitor the status of their manuscripts online .

    JPR 

     Journals provides immediate  access  to its content on the principle that making research available to the public supports a greater global exchange of knowledge, meaning:

    • Everyone has access to the full-text of articles published in JPR Solutions Journals; manuscripts are available to the readers without subscription, always suggestion, comments are welcome .
    • Papers are  released in various format

     

  • EDITORIAL BOARD 

    Editors:  

     Sumita Mukherjee

    Dr. B.L.R. Madhavi , [Area of Interest: Pharmaceutics] Dept. of Pharmaceutics ,Acharya & BM Reddy College of Pharmacy, (ABMRCP) Dr. Sarvepalli Radhakrishnan road, Soldevanvahalli,  Bangalore –560090,Karnataka,India.

    ·Prof. Dr. G. Babu, M. Pharm., Ph. D.,Professor & Principal, [Area of Interest: Pharmaceutical Analysis, Natural Products Chemistry] Devaki Amma Memorial College of Pharmacy,Chelembra,Malappuram dist. 673634,Kerala,India.

    ·Dr. Suvardhan Kanchi, [Area of Interest: Analytical Chemistry, Biosensors, Green Synthesis of NPs, Dye Sensitized Solar cells] Department of Chemistry,Durban University of Technology,Durban,South Africa.

    ·Dr. Zhiyong Peng,Department of CardioVascular Sciences,Heart Institute,East Carolina University,115 Heart Dr,Greenville, NC 27834,USA.

    ·Dr. Debasish Bandyopadhyay [Area of Interest:Herbal Antioxidant Drug Study, Calcutta University, Kolkata.

    ·Dr. Ryszard Amarowicz , [ Area of Interest: Phenolic Compound, antioxidants, Chromatography, food analysis, bioactive compd of plant]Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland.

    ·Dr. Y. K . Gupta, Professor and Head,Dept. of Chemistry,B K Birla Institute of Engineering and Technology,CEERI road,Pilani (Rajasthan), India.

    ·Dr. Bishwambhar Mishra , (Assistant Professor, Dept. of Biotechnology, Sreenidhi Institute of Science and Technology,Hyderabad, India)

    ·Dr. Sat Pal Singh Bisht, ( Professor, Dept of Zoology, Kumaun University, Nainital-263002, Uttarakhand, India )

    ·Dr.Mohamed El Houseiny El Sebeay Shams,Head of the Department of Pharmacy Practice,Oman Pharmacy Institute,Ministry of Health, PO Box 1928, Muscat 114, Oman.

    ·Dr. Smaranika Pattnaik, School of Life Sciences, Sambalpur University, Burla 768019, Odisha,India.

    ·Dr. Kondawar M. S.Prof. and Head,Department of Quality Assurance,Appasaheb Birnale college of Pharmacy,South Shivajinagar, Sangli-Miraj road,Sangli - 416416 (MS)India.

    ·Dr. Md. Amirul Islam , Pharmacy Discipline,Khulna University,Khulna-9208, Bangladesh·Prof. Vaithiamanithi Perumal,SAIMS Medical College, Indore,India·Dr. Biswa Mohan Sahoo,HOD & Associate Professor,Dept. of Medicinal Chemistry,Vikas College of Pharmacy,Putrela Road, Vissannapeta, Krishna Dist-521215 ,Andhra Pradesh, India·Dr. Popat Mohite.Associate Professor, Dapartment of Pharmaceutical Chemistry, MES's College of Pharmacy, SonaiTal- Newasa Dist-Ahmednagar, Maharashtra-414105·Dr.M.Swaroopa, UGC Post Doctoral Fellow in Biomedicine, Division of Zoology, Sri Padmavati Mahila Visvavidyalayam, Tirupati,A.P,India·Dr. Jiafeng Geng, School of Chemistry and Biochemistry, Georgia Institute of Technology, 315 Ferst Dr, Atlanta, GA 30332,  United States·Dr. M. V. Kumudhavalli., [Area of Interest: Phytochemistry and Pharmacology] Dept. of Pharmaceutical Analysis,Vinayaka Mission’s College of Pharmacy, Yercaud Main Road, Kondappanaikenpatty, Salem- 636008, T.N, India·Dr.Rajkumar Venkatadri [ area of Interest: Cancer Research, Pharmaceutical Sciences, Molecular Biology, Drug Invention], Department of Pharmaceutical Sciences, School of Pharmacy, Hampton University, 100 E Queen St, Hampt, VA 23668, USA·Dr. Pankaj  Goyal, Amity Institute of Microbial Technology, Amity University, Noida, Sec-125, India·Dr. Bao Yang, PhD, Professor, [Area of Interest: Botany, enzyme ,bioactive compounds] South China Botanical Garden (Formerly South China Institute of Botany), Chinese Academy of Sciences, Guangzhou 510650, China.Dr. Appala Raju. Nemala, [Area of Interest: Pharmaceutical Analysis] , Department of Pharmaceutical Chemistry,8-2-249, Mount Pleasant, Road#3, Banjara Hills,Sultan-ul-Uloom College of Pharmacy, Hyderabad, Telanagana State. India

    ·Dr. Goutam Kumar Jana,Department of Pharmacognosy,Gayatri College of Pharmacy,At- Gayatri Vihar, PO- Jamadarpali, Via- Sason,Dist- Sambalpur, Pin- 768200, OrissaIndia

    ·Dr. Bhushankumar Suresh Sathe ,[Area of Interest: Pharmacy,Medicinal Chemistry], Department of Pharmaceutical Chemistry, MGSM’S Smt. Sharadchandrika Suresh Patil, College of Pharmacy,Chopda-425107, M.H., India

    ·Dr. Versha Parcha,[Area of Interest: Natural products and Drug Discovery] Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences and Research,Balawala,  Dehradun,  Uttarakhand, India

    ·Dr.Tareeka Dilip Sonawane,[Area of Interest: Biotechnology and Bioinformatics (Reproductive toxicity, Molecular Biology)] D.Y.Patil University ,School of Biotechnology and Bioinformatics Level 5 , Sector 15, Plot No. 50 ,  CBD Belapur, Navi Mumbai  400 614,Maharashtra  India

    ·Dr. Sabyasachi Maiti, [Area of Interest: Pharmaceutics (Novel Drug Delivery, Pharmacokinetics, Biopolymer Hydrogels)], Gupta College of Technological Sciences, Ashram More, GT Road, Asansol-713301, West Bengal, India

    ·Raghunath Singh,Senior Research Fellow (PhD Scholar), [Area of Interest: Nueropsychopharmacology, Ethnopharmacology, Inflammation, Neurodegenerative disorders]  University Institute of Pharmaceutical SciencesUGC-Center of Advanced Study (UGC-CAS),Panjab University,Chandigarh-160014,India

    ·Mohammed Rageeb Mohammed Usman, [Area of Interest: Pharmacognosy] ,Dept. of Pharmacognosy, Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda 425107, Dist - Jalgaon Maharshtra, India.

    ·Dr. Durgacharan Arun Bhagwat, [Area of Interest: Pharmaceutics (Development of Novel Drug Delivery System)],  Dept of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Pin: 416 013, M.S. India.

    ·Dr.. Abhishek Laxminarayan Sharma, Q.A./ Q.C. Manager- Ayurvedic Section; Choksi Laboratories Limited; Vapi,India

    ·Dr. Agnimitra Dinda,[Area of Interest: Pharmaceutics ], Dept of Pharmaceutics, Gyana Jyothi College of Pharmacy,7-48/1, Gyana Jyothi Nagar,Uppal Bus Depot,Hyderabad-98,India

    ·Dr. A. Sai Ramesh, M.S. (by Research), Ph.D.,[Area of Interest: Medicinal Biochemistry, Natural Products, Medicinal Plants] Assistant Professor, Department of Biotechnology,Sree Sastha Institute of Engineering and Technology, Chemberambakkam, Chennai 600123, Tamil Nadu,India.

    ·Dr. Renu Sankar, Postdoctoral Researcher, [Area of Interest: Nanobiotechnology],Biomolecular Therapeutics Laboratory, Department of Chemistry, Sungkyunkwan University, Suwon, 440-746, South Korea.

    Dr. Shashikant  V. Bhandari.[Area of Interest: Drug design and development , Molecular modeling studies viz. QSAR, Anti-cancer], Professor, Head, Department of Pharmaceutical Chemistry, AISSMS College of pharmacy,  Near RTO Office , Kenedy Road, Pune-4110001 ,M.H.,India.

    Dr. Dhavalkumar V Patel, [Area of Interest: Pharmaceutics ] B K Mody Govt Pharmacy College,NR AJI DAM,Polytechnic Campus,Rajkot-360003, Gujarat,India.

    ·Mr. Mayank Sharma, Doctoral Research Fellow, [Area of Interest:  Pharmaceutics(Drug Delivery, Nanotechnology) Department of Pharmaceutics, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshashila Campus, Khandwa Road, Indore (M.P.) – 452001, India

    Dr.Senthil Venkatachalam , Pharmaceutics [Area of Interest:Muco/Bioadhesive drug delivery system, Nanostructured Lipid carrier system], JSS College of Pharmacy, Rocklands, Ooty, Tamil Nadu 643001,India.

    Dr. M.R Jayapal, [Area of Interest:Organic chemistry,Analytical chemistry,Nanotechnology]Dept of Chemistry, National University of Cordoba,Argentina.

    Dr. Quan Wang,[ Area of Interest : fluorescence spectroscopy, single-molecule detection, biophysics, microfluidics, optics] Department of Chemistry, Stanford University, MC5080,USA.

    Advisory Board:

    ·Dr. Fengguo Xu,Dept of Epidemiology and Public Health,Yong Loo Lin School of Medicine,National University of Singapore,MD3, 16 Medical Drive, Singapore 117600.

    ·Dr. D. Nagasamy Venketash,Dept of Pharmaceutics,JSS College of Pharmacy,Ooty - 643 001. Tamil Nadu. India.

    ·Dr. G.S. Lavekar, Former DG, CCRAS – AYUSH (Govt. of India)

    ·Dr. Debasish Bandyopadhyay ( Calcutta University, Kolkata)

    ·Dr. Vijay Dhondiram Wagh, Pharmaceutical Technology, India

    ·Dr. Ramdas Bhanudas Pandhare[Area of Interest: Pharmacology], University of Pune, India

    ·Dr. Faiyaz Ahamed, India

    ·Dr. Shete R.V, India

    ·Dr. Ramesh Putheti, United States

    ·Dr. Yuanxiong Deng, China

    ·Dr. Praveen Bansal, India

    ·Dr. C. Rajasekaran, India

    ·Dr. A. K. Meena, (NIAPR, Patiala) India

    · Dr. Jongwha Chang, USA 

    · Dr. Somasekhar Penumajji, South Korea

    ·Dr. Geetha Kodali,Mexico

     [ Join the Editorial board by sending brief biodata mail OR Register  in login page : info@jprsolutions.info ]

  • Review process:

    Papers will usually be acknowledged upon receipt. Author(s) have to submit duly signed Copyright form.

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    Note:

    • All authors are required to sign this above copyright form. However, first author & corresponding author may sign on behalf of others in case of non-availability of other authors, after taking consent of all authors/coauthors.
    • No addition, deletion or change in the sequence of authors is allowed at a later stage.

    The editorial decision is final. The editorial board reserves the right to make corrections/revisions aimed at greater clarity or conformity of style.

Recent Manuscripts published

Journal: Journal of Pharmacy Research

Title: Aqueous leaf extract of Tulsi (Ocimum sanctum) protects against high fat diet-induced injury to rat liver through antioxidant mechanisms: a dose- and time-dependent study
Section: Research Article
Category: Pharmacology
Country: India
View Article

Background: Consumption of high fat induces oxidative stress by disturbing the activity of a number of antioxidant enzymes in rat liver. The present study was designed to investigate the efficacy of the aqueous leaf extract of Tulsi (Ocimum sanctum) to provide protection against the High Fat Diet (HFD) induced oxidative injury in rat liver. Objective: The aim of the present study was to examine whether administration of aqueous extract of the leaves of Ocimum sanctum (Tulsi) do possess a protective effect against HFD-induced oxidative stress in rat liver. Materials and method: The dose and time dependent changes were studied in the liver of male Wistar rats following the oral feeding of the rats with HFD for a period of 5 days, 10 days and 15 days to determine the maximum oxidative damage in the hepatic tissue of rats without any mortality. Pre-treatment of rats with aqueous leaf extract of Tulsi (TLE) was also studied by oral administration of TLE with the increasing doses (50, 100, and 200 mg/kg BW) against HFD induced oxidative stress in rat liver to determine the minimum effective dose of Tulsi, which can provide protection to the liver damage and minimize the alterations in a concentration dependent manner. The alterations in the activity of some of the important different bio-markers of hepatic damage, biomarkers of oxidative stress, and activities of the antioxidant enzymes were studied. Histo-pathological and histo-chemical alterations were also studied through H-E staining and Picrosirius red staining. Scanning electron microscopy was done to see the structural integrity of hepatic tissue surface. Result: The studies revealed that the extract protected the biomarkers of organ damage, oxidative stress, antioxidant enzymes, pro-oxidant enzymes and oxidative stress index from being altered in the rat hepatic tissue following treatment with HFD. Conclusion: It can be concluded from the current work that this aqueous leaf extract of Tulsi possess antioxidant properties and may be used as a potential antioxidant supplement to combat oxidative stress-induced tissue damages due to high fat diet consumption.

Journal: Journal of Pharmacy Research

Title: Molecular modeling and docking studies on OXA-10 enzyme of Acinetobacter baumannii
Section: Research Article
Category: Bioinformatics (Genome & Sequence Analysis )
Country: India
View Article

The strains of Acinetobacter spp. producing Oxacillinase enzyme pose a crucial threat to clinicians worldwide due to limited treatment options against these strains. A 3D model of OXA-10 enzyme from A. baumannii was successfully predicted and its interaction with six different protease inhibitor compounds of cyanobacterial origin was studied. Among the six compounds tested, kempopeptin showed the good atomic contact energy and effective binding with OXA-10 enzyme, which indicate its ability to hydrolyze oxacillinase enzymes. Thus, this compound may be helpful in reducing the burden of infections caused by oxacillinase producing members of Acinetobacter spp, if used in combination with standard antibiotics.

Journal: Journal of Pharmacy Research

Title: Optimization of physiochemical parameters for the production of withaferin A employing cell suspension culture of Withania somnifera : A review
Section: Review Article
Category: Pharmaceutical Biotechnology
Country: India
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Withania  somnifera  (Ashwagandha )  is  a  plant  used  in  medicine  from  the  time  of presence by ayurveda, the  ancient  system  of  Indian  medicine  and  in  plant  biotechnology. The  dried  roots  and  leaves   of  the  plant  are  used  in  the  treatment  of  various  nervous  and  sexual  disorders. Medicinal  properties  of  plant  have  been  attributed  to  the  presence of  a  group  of  steroidal  lactones  which  are  known  as   withanolides  which  are  present  in  roots  and leaves. Withaferin  A  is  a  steroidal  lactone  being   derived  from  Withania  somnifera. It  is  used  in  ayurvedic  medicine. It  has  a  wide  range  of  activities  which  comes  under  pharmacy ,cardio protection, the  anti-inflammatory  agent ,  an  immuno  modulatory,  an   anti-angiogenesis, anti-metastasis  and anti-carcinogenic  property.  This  review  article  is     focusing  on   the  methodology  to  achieve  the  maximum  production  of  withaferin  A  employing cell  suspension  culture  of  Withania  somnifera.  As  withaferin  A  low  concentration  was  found  to  be  a  limiting  factor  in  previous  reports   on  Withania  somnifera . This  article  will  encompass  the  parameters  which  are  responsible  for  optimum  production  of  withaferin  A   employing  cell  suspension  culture  of  Withania  somnifera.