Drug Invention Today
ISSN NO: 0975-7619
Drug Invention Today (DIT) was first published in 2009 by JPR Solutions. It is a journal, which publishes reviews, research papers and short communications . 
• Novel Drug Delivery Systems • Nanotechnology & Nanomedicine • Biotechnology related pharmaceutical technology • Polymeric bio-conjugates • Biological macromolecules • Biomaterials • Drug Information • Drug discovery/development • Screening of drugs from natural & synthetic origins • Novel therapeutic strategies • Combinatorial chemistry and parallel synthesis • Clinical trials • Case Reports
 Impact FactorTM ( India ) = 0.897 as on date (08.05.2017)
  Scopus Indexed ( link http://www.scimagojr.com/journalsearch.php?q=21100202909&tip=sid&clean=0)
Journal Metrics for this   Drug Invention Today (Source ID: 21100202909): 2014 (SNIP) Source Normalized Impact Per Paper : 0.402; SCImago Journal Rank (SJR):0.301; Impact Per Publication : 0.517 (Top level : Life Science)
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  • Copyright Notice
  • Editorial Board
  • Author Guidelines
  • Indexing
  • Copyright notice & Permissions: 
    Upon acceptance of an article, authors will be asked to complete a "Copyright notice and permission letter". 
    Dear editor (Drug Invention Today),
    Sub: Submission of an original paper with copyright agreement and authorship responsibility ( submit by e-mail only)
     Topic entitled:
    I certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published or is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.
     
    Kindly find it suitable to publish in your esteemed journal.
    Thanking you
    Yours sincerely,
     
                                                                         
    Author name and address                                                             Signature
  • EDITORIAL BOARD 
    Editors:  
    Prof. S. Parial (Pharmacy, Pharmacognosy)
    Dr. Praveen Kumar Sharma (Associate Professor) [Area of Interest:  Medicinal Chemistry ] Department of Chemistry, Lovely Professional University, Punjab (India)-144411
    ·Dr.M.Swaroopa, UGC Post Doctoral Fellow in Biomedicine, Division of Zoology, Sri Padmavati Mahila Visvavidyalayam, Tirupati,A.P,India
    ·Dr. Fengguo Xu,Dept of Epidemiology and Public Health,Yong Loo Lin School of Medicine,National University of Singapore,MD3, 16 Medical Drive, Singapore 117600.
    ·Dr. D. Nagasamy Venketash,Dept of Pharmaceutics,JSS College of Pharmacy,Ooty - 643 001. Tamil Nadu. India.
    ·Dr. Suvardhan Kanchi, Department of Chemistry,Durban University of Technology,Durban,South Africa.
    ·Dr. Zhiyong Peng ,Department of CardioVascular Sciences,Heart Institute,East Carolina University,115 Heart Dr,Greenville, NC 27834,USA.
    ·Dr. Y. K . Gupta, Professor and Head,Dept. of Chemistry,B K Birla Institute of Engineering and Technology,CEERI road,Pilani (Rajasthan), India.
    ·Dr. Bishwambhar Mishra , (Assistant Professor, Dept. of Biotechnology, Sreenidhi Institute of Science and Technology,Hyderabad, India)
    Dr. Tanay Pramanik  Assistant Professor in Department of Chemistry, Research Coordinator in School of Chemical Engineering and Physical Sciences,Lovely Professional University (LPU), India.
    ·Dr. Sat Pal Singh Bisht, ( Professor, Dept of Zoology, Kumaun University, Nainital-263002, Uttarakhand, India )
    ·Dr.Mohamed El Houseiny El Sebeay Shams (Head of the Department of Pharmacy Practice,Oman Pharmacy Institute,Ministry of Health, PO Box 1928, Muscat 114, Oman)
    ·Dr. Smaranika Pattnaik, (School of Life Sciences, Sambalpur University, Burla 768019, Odisha,India)
    ·Dr. Kondawar M. S.Prof. and Head,Department of Quality Assurance,Appasaheb Birnale college of Pharmacy,South Shivajinagar, Sangli-Miraj road,Sangli - 416416 (MS)India.
    ·Dr. Md. Amirul Islam , Pharmacy Discipline,Khulna University,Khulna-9208, Bangladesh
    ·Prof. Vaithiamanithi Perumal,SAIMS Medical College, Indore,India
    ·Dr. Biswa Mohan Sahoo,HOD & Associate Professor,Dept. of Medicinal Chemistry,Vikas College of Pharmacy,,Putrela Road, Vissannapeta, Krishna Dist-521215 ,Andhra Pradesh, India
    ·Dr. Popat Mohite.Associate Professor, Dapartment of Pharmaceutical Chemistry, MES's College of Pharmacy, SonaiTal- Newasa Dist-Ahmednagar, Maharashtra-414105
    ·Dr. Shankar Ananth,India
    ·Dr. Wei Zhang, China
    ·Dr. Goutam Kumar Jana,Department of Pharmacognosy,Gayatri College of Pharmacy,At- Gayatri Vihar, PO- Jamadarpali, Via- Sason,Dist- Sambalpur, Pin- 768200, OrissaIndia
    ·Dr. Asim Ahmad Elnour,UAE
    ·Dr. Geetha Kodali,Mexico
    ·Dr. Syed Haris Omar, Pharmacology,Qassim University,Saudi Arabia
    ·Dr. Jaykaran (Medical Sciences), India
    ·Dr. Vijay Dhondiram Wagh, Pharmaceutical Technology, India
    ·Dr. Ramdas Bhanudas Pandhare, University of Pune, India
    Advisory Board:
    ·Dr. G.S. Lavekar, Former DG, CCRAS – AYUSH (Govt. of India)
    ·Dr. Debasish Bandyopadhyay ( Calcutta University, Kolkata)
    ·Dr. Faiyaz Ahamed, India
    ·Dr. Shete R.V, India
    ·Dr. Ramesh Putheti, United States
    ·Dr. Yuanxiong Deng, China
    ·Dr. Praveen Bansal, India
    ·Dr. C. Rajasekaran, India
    ·Dr. A. K. Meena, (NIAPR, Patiala) India
    · Dr. Jongwha Chang, USA 
    · Dr. Somasekhar Penumajji, South Korea
     
     [ Join the Editorial board by sending brief biodata mail OR Register  in login page : info@jprsolutions.info ]
  • PREPARATION OF MANUSCRIPTS 
    Manuscripts must be in "Times New Roman" font-size 10, with double spacing. Please arrange the manuscript as follows: Title page, abstract, introduction, methods, results and discussion, and references, tables, figure captions and figures. Number all pages consecutively at the bottom, beginning with the title page. Figures and tables must be cited in the manuscript.
    It is important that the file be saved in the native format of the word processor used. The text should be in single-column format. Keep the layout of the text as simple as possible. Most formatting codes will be removed and replaced on processing the article. In particular, do not use the word processor's options to justify text or to hyphenate words. However, do use bold face, italics, subscripts, superscripts etc. When preparing tables, if you are using a table grid, use only one grid for each individual table and not a grid for each row. If no grid is used, use tabs and not spaces to align columns. The electronic text should be prepared in a way very similar to that of conventional manuscripts. Note that source files of figures, tables and text graphics will be required whether or not you embed your figures in the text. See also the section on electronic artwork. To avoid unnecessary errors, you are strongly advised to use the 'spell-check' and 'grammar-check' functions of your word processor. Lines must be numbered consecutively throughout the manuscript and all pages must be numbered.
     
    MANUSCRIPT STRUCTURE
    Subdivision - Numbered Sections: Divide the article into clearly defined and numbered sections. Subsections should be numbered 1.1 (then 1.1.1, 1.1.2, ...), 1.2, etc. (the abstract is not included in section numbering). Use this numbering for internal cross-referencing also: do not just refer to 'the text'. Any subsection may be given a brief heading. Each heading should appear on its own separate line.
    Introduction: State the objectives of the work and provide an adequate background, avoiding a detailed literature survey or a summary of the results.
    Material and methods: Provide sufficient detail to allow the work to be reproduced. Methods already published should be indicated by a reference: only relevant modifications should be described.
    Results and discussion: Results should be clear and concise. Discussions should explore the significance of the results of the work, not repeat them. A combined Results and Discussion section is often appropriate. Avoid extensive citations and discussion of published literature.
    Conclusion: The main conclusions of the study may be presented in a short conclusions section, which may stand alone or form a subsection of a Discussion or Results and Discussion section.
    Appendices: If there is more than one appendix, they should be identified as A, B, etc. Formulae and equations in appendices should be given separate numbering: Eq. (A.1), Eq. (A.2), etc.; in a subsequent appendix, Eq. (B.1) and so on. Similarly for tables and figures: Table A.1; Fig. A.1, etc.
     
    Title page information
    • Title: Concise and informative. Titles are often used in information-retrieval systems. Avoid abbreviations and formulae where possible. A short running title not exceeding 40 characters must be provided.
    • Author names and affiliations: Where the family name may be ambiguous (e.g., a double name), please indicate this clearly. Present the authors' affiliation addresses (where the actual work was done) below the names. Indicate all affiliations with a lower-case superscript letter immediately after the author's name and in front of the appropriate address. Provide the full postal address of each affiliation, including the country name. The journal reserves the right to ask for the contribution of each author to an article.
    • Corresponding author: Clearly indicate who will handle correspondence at all stages of refereeing and publication, also post-publication. Ensure that telephone and fax numbers (with country and area code) are provided in addition to the e-mail address and the complete postal address. Contact details must be kept up to date by the corresponding author.
    • Present/permanent address: If an author has moved since the work described in the article was done, or was visiting at the time, a 'Present address' (or 'Permanent address') may be indicated as a footnote to that author's name. The address at which the author actually did the work must be retained as the main, affiliation address. Superscript Arabic numerals are used for such footnotes.
     
    Abstract: A concise and structured abstract is required under the headings like objectives, methods, results, and conclusions. The abstract should state briefly the purpose of the research, the principal results and major conclusions. An abstract is often presented separately from the article, so it must be able to stand alone. For this reason, References and non-standard or uncommon abbreviations should be avoided, but if essential they must be defined at their first mention in the abstract itself. The abstract should not exceed 250 words.
    Graphical abstract: A Graphical abstract is required for this journal. It should summarize the contents of the article in a concise, pictorial form designed to capture the attention of a wide readership online. Authors must provide images that clearly represent the work described in the article. Graphical abstracts should be submitted as a separate file in the online submission system. Image size: Images should be clear enough and of appropriate size (5 inch × 7 inch or larger) for better reproduction. If scanned, they should be scanned at minimum of 300 dpi. Color images must be CMYK. Line art drawing must have a minimum resolution of 1200 dpi. Permission to reproduce any borrowed image must be obtained from the author and the publisher. Preferred file types: TIFF, and JPEG files.
    Keywords: A maximum of 5 keywords are required after the abstract.
    Acknowledgements: Acknowledgements should be given in a separate section at the end of the article before the references.
    Artwork - Electronic artwork:
    • Make sure you use uniform lettering and sizing of your original artwork.
    • Save text in illustrations as 'graphics' or enclose the font.
    • Only use the following fonts in your illustrations: Arial, Courier, Times, Symbol.
    • Number the illustrations according to their sequence in the text.
    • Use a logical naming convention for your artwork files.
    • Provide captions to illustrations separately.
    • Produce images near to the desired size of the printed version.
    Submit each figure as a separate Excel file.
    Journal Articles
    1) George JN, Woolf SH, Raskob GE, Wasser JS, Aledrot LM, Ballem PJ. Idiopathic thrombocytopenic purpura: A practice guideline developed by explicit methods of the American Society of Hematology. Blood, 1996, 88, 3–40.
    2) Driessens FCM, Boltong MG, Bermudez O, Planell JA. Formulation and setting times of some calcium orthophosphate cements: A pilot study. J. Mater. Sci: Mater. Med., 1993, 4, 503–508.
    Books
    Strunk W, Jr, White EB. The Elements of Style 4th ed. Longman, New York, 2000.
    Book Chapters
    Mettam GR, Adams LB. How to prepare an electronic version of your article. In: Jones BS, Smith RZ (Eds.),Introduction to the Electronic Age. E-Publishing Inc., New York, 2009, pp. 281–304.
    Web references
    As a minimum, the full URL
  • 1. http://www.scimagojr.com/journalsearch.php?q=21100202909&tip=sid&clean=0
     
    SCImago Journal & Country Rank
     
    2. http://endnote.com/downloads/style/drug-invention-today
    3. http://publicationethics.org/members/drug-invention-today
    4. https://scholar.google.co.in/citations?user=DvHkMU0AAAAJ&hl=en
    5.http://www.citefactor.org/journal/index/1532/drug-invention-today#.VcYmm3 Gqqko  
    6. http://www.ncbi.nlm.nih.gov/nlmcatalog/101619441
    7. http://journaldir.petra.ac.id/browse_journal2.php?id=17101
    8. http://www.webcitation.org/archive.php (author can freely upload )
    9.http://www.citationmachine.net/drug-invention-today/cite-a-journal/manual (author can freely upload)
    10. http://en.journals.sid.ir/JournalList.aspx?ID=23338
    11. http://ores.su/en/journals/drug-invention-today/
    12. http://pubget.com/journal/0975-7619/drug-invention-today
    13. http://www.journals4free.com/link.jsp?l=17953464
    14. http://library.wur.nl/WebQuery/clc/2032712 
    15. http://trove.nla.gov.au/work/38532528?versionId=51078376
     
      scopus
     
     

Recent Manuscripts published

Journal: Drug Invention Today

Title: Challenges in delivery of chemotherapeutic agents for the treatment of brain cancer and the scope of nanoparticulates
Section: Review Article
Category: Drug Release Profiles
Country: India
View Article

Brain tumor remains one of the most dreadful, poorly prognosed cancer despite advances in understanding the molecular basis of carcinogenesis. Treatment of brain tumors requires a multidisciplinary approach that includes combination of surgery, radiation, or chemotherapy. The major hindrance to prognosis of brain tumor is the autoprotective nature of the brain and blood–brain barrier (BBB). The approaches involves deliberate opening of the tight junctions of the BBB or delivery of drugs “through” or “behind” BBB by manipulating the physicochemical properties of the drug and have major drawbacks including irreversible opening of BBB that potentially allows the entry of exogenous material such as viruses and bacteria, and allows limited spatial distribution of drug. Nanoparticles (NPs) focus on the administration of nanometric size particles loaded with chemotherapeutic agent, monoclonal antibodies, genes, proteins, peptides, and other entities. Due to its small size and modifiability warrant their selective uptake by the tumor cells. They can be formulated out of variety of substance and can carry multiple loads of drugs directing the substance toward the tumor cells. Thus in comparison to conventional therapies, NPs reduces the side effects. Number of drug delivery strategies has been developed to overcome challenges presented by the BBB. One technique that holds promise for bypassing the BBB to deliver drugs to the brain the spillover effect of drug to normal tissue is intranasal delivery. The intranasal delivery of NP loaded anticancer drug provides a practical and noninvasive method for delivering therapeutic agents to the brain due to the unique anatomical connections.

Journal: Drug Invention Today

Title: Proteins P53 and BCL-2 in pathogenesis of missed and spontaneous abortions
Section: Research Article
Category: Biomaterials ( Synthetic and Natural )
Country: India
View Article

mRNA expression of p53, p21, BCL-2, Bax, Noxa and MDM2 in decidual tissue (endometrium) of 50 patients with missed abortions, 47 patients with spontaneous abortions, and 57 patients with artificial abortion (control group) at 6–10 weeks of gestation were examined using reverse transcription quantitative polymerase chain reaction. Expression of p53 mRNA had no significant differences in patients with missed and spontaneous abortions. Significant increase of proapoptotic protein Noxa, accompanied with anti-apoptotic protein BCL-2 elevation was observed in the endometrium of patients with missed abortions. In patients with spontaneous abortions, only increase of Noxa has been observed. It can be suggested, that increase of BCL-2 in patients with missed abortions, when embryo resorption has happened, protects nearby embryos in case of multiple pregnancies. No significant changes of p21 mRNA were discovered in both groups, which indicates, that cell cycle arrest is not involved in the pathogenesis of early miscarriages. No significant changes of Bax and MDM2 mRNA expression were discovered in decidual tissue of patients with missed and spontaneous abortions.

Journal: Drug Invention Today

Title: Hypolipidemic of ethanolic extract of Salam bark (Syzygium polyanthum (Wight) Walp.) from Indonesia (Preclinical study)
Section: Research Article
Category: Clinical Drugs Related Study
Country: India
View Article

Aim: The aim of this research to evaluate the effect of 70% ethanol extract of Salam bark (Syzygium polyanthum (Wight) Walp.) ethanolic extract of Salam bark (EESB) from Indonesia toward blood cholesterol, triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels in male rats Wistar strain. Materials and Methods: This study was a preclinical experimental study with a pre- and post-test with control group design. A total of 25 white male rats Wistar strain were divided into five groups with simple random sampling. The groups were negative control (aquadest), positive control (simvastatin 0.2 mg/200 g bw/day), dose I (0.36 g/200 g bw/day), dose II (0.72 g/200 g bw/day), and dose III (1.44 g/200 g bw/day). Blood cholesterol, triglyceride, LDL, and HDL levels were measured before and after applying treatment. This study was held for 15 days and data were analyzed by one-way ANOVA test followed by least significant difference test and Kruskal–Wallis followed by Mann–Whitney test. Results: The 70% EESB (S. polyanthum (Wight) Walp.) at dosage of 0.72 and 1.44 g/200 g bw/day can decrease blood cholesterol; triglyceride and LDL levels (P < 0.05), meanwhile, the extract at dosage of 0.36, 0.72, and 1.44 g/200 g bw/day can increase serum HDL levels (P < 0.05). Conclusions: The 70% EESB (S. polyanthum (Wight) Walp.) decreases the serum cholesterol, triglyceride, LDL, and increase HDL levels significantly in hypercholesterolemia male rats Wistar strain.