Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001006
Title: Hepatoprotective and antioxidant effect of Hesperidin against Isoniazid, Rifampicin and Pyrazinamide induced hepatotoxicity in rats.
Category: Pharmacology
Section: Research Article
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    Background: Drug induced hepatotoxicity is found to be one of the foremost reason for Liver injury. Pharmacological intervention preferably using natural bioactive compounds to prevent hepatotoxicity is the need of the hour. So a study was designed to investigate the protective effect of naturally occurring flavonoid Hesperidin on Isoniazid (H), Rifampicin(R) and Pyrazinamide (Z) induced hepatotoxicity and oxidative stress. Materials and Methods:Rats were divided into four different groups (n=6), control, HRZ, HRZ plus Hesperidin , standard group HRZ plus silymarin p.o for 50 days and after rats were sacrificed blood and liver were collected and used for biochemical and histological studies. RESULTS: Hepatotoxicity induced by HRZ was evidenced by a significant increase in liver marker enzyme such as alanine transaminase(ALT) ,aspartate transaminase (AST), alkaline phosphatase (ALP) , Gamma glutamyl transferase (gGT), Lactate dehydrogenase (LDH), lipid peroxidative products such as Lipid hydroperoxides (LHP), conjugated dienes(CD), malondialdehyde (MDA) as well as decreased the level of antioxidant enzymes superoxide dismutase(SOD),catalase(CAT), glutathione reductase(GR), reduced glutathione(GSH), glutathione S transferase(GST), glutathione peroxidase(Gpx), vitamin C and E(VIT E& C) in experimental rats. These changes were not observed in the group where Hesperidin was administered along with HRZ. The effect of Hesperidin was compared with a standard drug, silymarin. The changes in biochemical parameters were supported by histopathological evidence. CONCLUTION:  It is to be concluded that the Hesperidin can be used as a protective agent against antitubercular drug induced oxidative liver injury and necrosis.

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    Author(s) Name:

    1S.Nathiya, 2 Dr.S.Rajaram.MD, 3Dr.Philips Abraham, 4Mrs. G. vennila,

    5Dr. Sivakami

    Affiliation(s) Name:

    1Tutor,Department of Pharmacology,Vinayaka Mission Kirupananda Variyar Medical College, Vinayaka Missions University,Salem,Tamil Nadu,India
    2Professor and Head,Department of Pharmacology,Vinayaka Mission Kirupananda Variyar Medical College,Salem, Tamil Nadu,India
    3Associate Professor,Department of Biochemistry,Vinayaka Mission Kirupananda Variyar Medical College,Salem, Tamil Nadu,India
    4Lecturer,Department of Anatomy,KSR Dental college,Thiruchengode, Tamil Nadu,India
    5Assistant professor,Department of pathology,Vinayaka Mission Kirupanandha Variyar Medical College,Salem. Tamil Nadu,India 

    *Corresponding author.
    S.Nathiya,
    Tutor,
    Department of Pharmacology,
    Vinayaka Mission Kirupananda Variyar Medical College,
    Vinayaka Missions University,
    Salem,Tamil Nadu,India.

    Received on:24-05-2015; Revised on: 21-06-2015; Accepted on: 28-07-2015

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    Author:

    1S.Nathiya, 2 Dr.S.Rajaram.MD, 3Dr.Philips Abraham, 4Mrs. G. vennila,

    5Dr. Sivakami

    Title:Hepatoprotective and antioxidant effect of Hesperidin against Isoniazid, Rifampicin and Pyrazinamide induced hepatotoxicity in rats.
    Journal:Journal of Pharmacy Research
    Vol(issue):9 (July)
    Year:2015
    Page No: (469-475)
  • Experimental Methods Keywords

    Methodology:Hepatoprotective and antioxidant effect , Biochemical analysis
    Research Materials:Hesperidin, Isoniazid, Rifampicin, Pyrazinamide, Silymarin,

Keywords

Hesperidin Isoniazid Rifampicin Pyrazinamide Silymarin hepatotoxicity oxidative stress.

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