Journal: Journal of Pharmacy Research
Title: Review on various techniques of solubility enhancement of poorly soluble drugs with special emphasis on solid dispersion
Category: Pharmaceutics
Section: Review Article
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Abstract
A success of formulation depends on how efficiently it makes the drug available at the site of action. Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecules especially in oral formulation. But most of the time it becomes challenging to formulate poorly water soluble drugs. Therefore it is necessary to improve solubility of drug by various ways like salt formation, co-solvency, and addition of solublizing agent, micronization, and complexation. Although these techniques have commonly been used to increase dissolution rate of the drug, there are practical limitations with these techniques, the desired bioavailability enhancement may not always be achieved. One such formulation approach that has been shown to significantly enhance absorption of such drugs is to formulate/prepare solid dispersions.In this review we concentrated on improvement of the solubility of poorly water soluble drugs by preparing solid dispersion using various methods.
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About the authors and Affiliations
Author(s) Name: Mrs. Meera C. Singh*1, A. B. Sayyad, Dr. S. D. Sawant
Affiliation(s) Name: *1 Asst. Professor (Pharmaceutics) Smt. Kashibai Navale College Of Pharmacy, Saswad Kondhwa Road, S. No 40/4, near Octroi post, Kondhawa (Bk), Pune 411048, Maharashtra, India.
2 B.Pharm. Smt. Kashibai Navale College Of Pharmacy, Saswad Kondhwa Road, S. No 40/4, near Octroi post, Kondhawa (Bk), Pune 411048, Maharashtra, India.
3 Professor & Principal Smt. Kashibai Navale College Of Pharmacy, Saswad Kondhwa Road, S. No 40/4, near Octroi post, Kondhawa (Bk), Pune 411048, Maharashtra, India.*Corresponding author.
Mrs. Meera C. Singh ,Asst. Professor (Pharmaceutics)
Smt. Kashibai Navale College Of Pharmacy,
Saswad Kondhwa Road, S. No 40/4, near Octroi post,
Kondhawa (Bk), Pune 411048, Maharashtra, India.
Received on: 15-06-2010; Revised on: 19-08-2010; Accepted on:13-09-2010-
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Author: Mrs. Meera C. Singh*1, A. B. Sayyad, Dr. S. D. Sawant
Title: Review on various techniques of solubility enhancement of poorly soluble drugs with special emphasis on solid dispersion Journal: Journal of Pharmacy Research Vol(issue): 3 (October) Year: 2010 Page No: (2494-2501) -
Experimental Methods Keywords
Methodology: bioavailability, salt formation, co-solvency, solublizing agent, micronization, complexation, solid dispersion. Research Materials: Poorly soluble drugs
Keywords
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