Journal: Journal of Pharmacy Research
Title: The diverse pharmacological importance of Pyrazolone Derivatives : A Review
Category: Pharmaceutical Chemistry
Section: Review Article
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Abstract
Scientific research programs and reports are continuously pouring in with respect to improvised synthetic techniques to prepare numerous pyrazolone derivatives and with regard to their diverse biological, pharmacological and chemical applications. When pyrazolones were discovered, they were only known as NSAID but in recent times, they are known to exhibit antioxidant, anticancer, antibacterial and several other pharmacological actions. These derivatives were withdrawn from the market because of their adverse effects such as agranulocytosis, skin rashes and blood dyscrasis etc, but recently they are again finding their place in the market and are being extensively used in cerebral ischemia and cardio vascular diseases. Since its introduction into medicine, there have been more than 1000 compounds made in an effort to find others with more potent analgesic action combined with less toxicity. Keeping in view the increasing importance of these derivatives, a need for the review is felt. This review deals with up to-date literature on biological and pharmacological properties of pyrazolone derivatives.
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About the authors and Affiliations
Author(s) Name: G Mariappan*1, B.P Saha1, L. Sutharson2, Ankit2, S. Garg2, Lipika Pandey1, Deepak kumar1
Affiliation(s) Name: 1Department of Pharmaceutical Chemistry, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim-737136.
2Department of Pharmacology, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim-737136.*Corresponding author.
G Mariappan
Department of Pharmaceutical Chemistry,
Himalayan Pharmacy Institute, Majhitar,
Rangpo, East Sikkim-737136.
Received on: 18-08-2010; Revised on: 16-10-2010; Accepted on:15-11-2010-
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Author: G Mariappan*1, B.P Saha1, L. Sutharson2, Ankit2, S. Garg2, Lipika Pandey1, Deepak kumar1
Title: The diverse pharmacological importance of Pyrazolone Derivatives : A Review Journal: Journal of Pharmacy Research Vol(issue): 3 (December) Year: 2010 Page No: (2856-2859) -
Experimental Methods Keywords
Methodology: cardio protective, Antioxidant, Anticancer. Research Materials: Pyrazolones, Edaravone
Keywords
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