Journal: Journal of Pharmacy Research
Title: Design and development of sustained release microspheres of Quetiapine Fumarate using 32 full factorial design
Category: Pharmaceutics
Section: Research Article
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Abstract
The objectives of this investigation were to prepare sustained release microspheres of the anti-psychotic drug, quetiapine fumarate, using ethyl cellulose as the polymer and evaluate it’s encapsulation efficiency, release characteristics in vitro; utilizing emulsion solvent evaporation and extraction technique. A 32 factorial factorial design was applied to investigate the influence of drug: polymer ratio and average particle size on release characteristics. The drug release was proportional to square root of time, indicating that the drug release from ethyl cellulose microspheres was diffusion controlled. The optimized batch showed no signs of interaction with sustaining the drug release up to 12 h along with identical release behavior to that of marketed sustained release tablet. The sphericity and smoothness of microspheres were also confirmed by scanning electron microscopy study.
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About the authors and Affiliations
Author(s) Name: Jaydeep Patel*; Anjali Dhingani; Mahesh Dabhi; Nilesh Patel; Mihir Raval & Navin Sheth
Affiliation(s) Name: Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, India
*Corresponding author.
Jaydeep Patel,
Department of Pharmaceutical Sciences,
Saurashtra University,
Rajkot-360005, Gujarat, India.
Received on: 20-09-2010; Revised on: 21-10-2010; Accepted on:19-11-2010-
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Author: Jaydeep Patel*; Anjali Dhingani; Mahesh Dabhi; Nilesh Patel; Mihir Raval & Navin Sheth
Title: Design and development of sustained release microspheres of Quetiapine Fumarate using 32 full factorial design Journal: Journal of Pharmacy Research Vol(issue): 3 (December) Year: 2010 Page No: (2871-2875) -
Experimental Methods Keywords
Methodology: Design and development, Research Materials: Quetiapine fumarate, emulsion solvent evaporation, in vitro drug dissolution
Keywords
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