Journal: Journal of Pharmacy Research

Article Id: JPRS-PB-00001241
Title: Effect of Pullulan concentration in fast dissolving films formulation and exploration of film properties
Category: Pharmaceutical Biotechnology
Section: Research Article
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    Background: Dissolvable oral thin films made from biopolymers gain much attention by pharmaceutical industries due to their fast dissolution capabilities. Objective: To cast the pullulan based film with plasticizer and silver nitrate and to explore the film properties for appearance, thickness, and disintegration and dissolution times for various films. Materials and methods: Aqueous solutions of pullulan (1-5%), 1-5 % of poly ethylene glycol (400, 600 varieties) and 1- 10 mM silver nitrate were formulated into films by solvent casting method. Thickness was measured by screw gauge and disintegration and dissolution times were physically observed and reported. Results: Formulated films were clear transparent, translucent and opaque in color. Least values of disintegration (15 sec) and dissolution (37 sec) times were observed and increase in the concentration of polymer and plasticizers increased the disintegration and dissolution times. Conclusion: The prepared pullulan based films can be used as fast dissolving films for systemic delivery of active pharmaceutical ingredients (APIs).

    Cite this article as: V S Rama Krishna Ganduri, N Meher Reethika, M Jayasai, V Sirisha, S Vasudha, Sudhakar Poda,Effect of Pullulan concentration in fast dissolving films formulation and exploration of film properties,Journal of Pharmacy Research 2016,10(5),211-215.

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    Author(s) Name:

    V S Rama Krishna Ganduri1,2,*, N Meher Reethika1, M Jayasai1, V Sirisha1, S Vasudha1, Sudhakar Poda2

    Affiliation(s) Name:

    1Department of Biotechnology, K. L. University, Green Fields, Vaddeswaram- 522502, Guntur (Dist), A.P., India.
    2Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur- 522510, A.P., India.

    *Corresponding author.
    G. V. S. Rama Krishna,
    Assistant Professor,
    Department of Biotechnology,
    K. L. University,
    Green Fields, Vaddeswaram,
    Guntur- 522 502, A.P., India.

    Received on:21-02-2016; Revised on: 27-03-2016; Accepted on: 26-04-2016

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    Author:

    V S Rama Krishna Ganduri1,2,*, N Meher Reethika1, M Jayasai1, V Sirisha1, S Vasudha1, Sudhakar Poda2
    Title:Effect of Pullulan concentration in fast dissolving films formulation and exploration of film properties
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (May)
    Year:2016
    Page No: (211-215)

  • Experimental Methods Keywords

    Methodology: Films formation, solvent casting method, dissolution, disintegration
    Research Materials:Biopolymers

Keywords

Fast dissolving films pullulan plasticizers dissolution disintegration.

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