Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001311
Title: Synthesis, and anti-cancer activity of some novel 3-(piperazin-1-yl)pyrazin-2-amine derivatives
Category: Pharmaceutical Chemistry
Section: Research Article
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    Aim: Synthesis of some new 2-aminopyrazine derivatives for the preliminary studies on cytotoxicity against breast cancer cells. Methods: The starting materials for the synthesis of new 2-aminopyrazine derivatives (PP1-18) are aryl-piperazines and 3,5-dibromo-2-aminopyrazine , which were prepared by the known literature procedure and condensed to get the new derivatives. The structure of newly synthesized compounds were characterized by spectral data and studied for their cytoxicity activity against breast cancer lines. Results: Some compounds showed moderate cytotoxicity on breast cancer cells and some have non toxic. Conclusions: In this article we reported the synthesis of a new (PP1-18) 2-aminopyrazine derivatives. The cytotoxicity studies showed that compounds were moderately toxic and some are non-toxic Hence the fact that the compounds prepared in this study are chemically new and not related to current medication and further work is clearly warranted.

    Cite this article as:Sadagopan Sekar, Nagaraja Naik, Ajjanna M Sridhara , Shivanna Yogish,Synthesis, and anti-cancer activity of some novel 3-(piperazin-1-yl)pyrazin-2-amine derivatives,Journal of Pharmacy Research 2016,10(6),419-425.

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    Author(s) Name:

    Sadagopan Sekar1, Nagaraja Naik *1, Ajjanna M Sridhara 2, Shivanna Yogish3

    Affiliation(s) Name:

    1 Department of Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
    2 Department of Industrial Chemistry, Kuvempu University, Shankaragatta -577 451, Karnataka, India
    3 Skanda Life Sciences Pvt Ltd, Sunkadakatte, Bengaluru-560091, Karnataka,India

    *Corresponding author.
    Dr. Nagaraja Naik,
    Professor,
    Department of Studies in Chemistry
    University of Mysore,Manasagangotri,
    Mysore – 570006,Karnataka, India.

    Received on:16-04-2016; Revised on: 23-05-2016; Accepted on: 19-06-2016

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    Author:

    Sadagopan Sekar1, Nagaraja Naik *1, Ajjanna M Sridhara 2, Shivanna Yogish3

    Title:Synthesis, and anti-cancer activity of some novel 3-(piperazin-1-yl)pyrazin-2-amine derivatives
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (June)
    Year:2016
    Page No: (419-425)
  • Experimental Methods Keywords

    Methodology:Synthesis, anti-cancer activity,MTT assay method
    Research Materials:some novel 3-(piperazin-1-yl)pyrazin-2-amine derivatives

Keywords

Breast cancer cells 2-aminopyrazine aryl-piperazines cytotoxicity 2-amino-3 5-dibromopyrazine.

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