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Abstract

Quinoxalines are well known and important nitrogen-containing heterocyclic compounds containing a ring complex made up of a benzene ring and a pyrazine ring. Diversely substituted quinoxalines and their derivatives embedded with variety of functional groups are important biological agents and a significant amount of research activity has been directed towards this class. Various methods have been worked out for their synthesis. Numerous quinoxaline derivatives have been found to possess considerable biological activities, which stimulated the research activity in this field. They have several prominent pharmacological effects, such as antimicrobial, antimycobacterial, antifungal, antiviral, antiprotozoal, antimalarial, antiinflammatory,anticonvulsant, antidepressant and anticancer activities. They also possess some potent receptor selective biological activity like AMPA receptor antagonist activity. Quinoxaline 1,4-di-N-oxides seem to be the most frequently studied quinoxaline type compounds. As a result, a large number of such quinoxalines using different synthetic methods for their preparation have been described in the chemistry literature. The present review provides an insight view to quinoxaline synthesis and its biological activities along with the compilation of recent patents on quinoxaline.

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	JPR Solutions

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