Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001369
Title: Niosomes: A Review
Category: Pharmaceutics
Section: Review Article
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  • Abstract

    Niosomes or non-ionic surfactant vesicles are microscopic lamellar structures formed on admixture of non-ionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. They are vesicular systems similar to liposomes that can be used as carriers of amphiphilic and lipophilic drugs. The method of preparation of niosome is based on liposome technology. The basic process of preparation is the same i.e. hydration by aqueous phase of the lipid phase which may be either a pure surfactant or a mixture of surfactant with cholesterol. After preparing niosomal dispersion, unentrapped drug is separated by dialysis centrifugation or gel filtration. A method of in-vitro release rate study includes the use of dialysis tubing. Niosomes are promising vehicle for drug delivery and being non-ionic, it is less toxic and improves the therapeutic index of drug by restricting its action to target cells. Niosomes are unilamellar or multilamellar vesicles formed from synthetic non-ionic surfactants. They are very similar to the liposomes. Niosomal drug delivery is potentially applicable to many pharmacological agents for their action against various diseases. Niosomes have shown promise in the release studies and serve as a better option for drug delivery system.

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  • About the authors and Affiliations

    Author(s) Name:

    Jaydeep D Yadav*,Priyanka R. Kulkarni, Kumar A Vaidya,Gurubas T Shelke

    Affiliation(s) Name:

    *Department of Pharmaceutical Sciences, N.D.M.V.P. Samaj’s, College of Pharmacy,Gangapur Road, Nasik- 422 002, Maharashtra, India.

    *Corresponding author.
    Jaydeep D Yadav
    *Department of Pharmaceutical Sciences,
    N.D.M.V.P. Samaj’s, College of Pharmacy,
    Gangapur Road, Nasik- 422 002,
    Maharashtra, India.

    Received on: 05-10-2010; Revised on: 14-12-2010; Accepted on:09-02-2011

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    Jaydeep D Yadav*,Priyanka R. Kulkarni, Kumar A Vaidya,Gurubas T Shelke

    Title:Niosomes: A Review
    Journal:Journal of Pharmacy Research
    Vol(issue):4 (March)
    Page No: (632-636)
  • Experimental Methods Keywords

    Methodology:surfactant, proniosomes
    Research Materials:Niosomes


Niosomes surfactant proniosomes

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