Journal: Journal of Pharmacy Research
Title: Solid lipid Nano particles-A versatile carrier system
Category: Pharmaceutics
Section: Review Article
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Abstract
Solid lipid nanoparticles (SLN) have been sought as alternative carriers for therapeutic agents it is administered by parenteral, oral, nasal and pulmonary routes. The research works in this area suggest that optimized conditions is required to incorporate hydrophobic or hydrophilic drugs and seem to fulfil the requirements for an optimum particulate carrier system. Solid lipid nanoparticles (SLNs) have been proposed as suitable colloidal carriers for delivery of drugs with limited solubility. Several obstacles frequently encountered with many compounds, with poor specificity and stability are at least partially overcome by delivering them using SLN.In this review it is intended to discuss the recent advances, various method of preparartion,methods of evaluation, various routes of administration, stability and pharmaceutical applications of SLN were discussed.
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About the authors and Affiliations
Author(s) Name: Anusha Rupenagunta 1, I.Somasundaram 2, V.Ravichandiran3, J.Kausalya4, B.Senthilnathan 5*
Affiliation(s) Name: 1 Department of Pharmaceutics, School of Pharmaceutical sciences, Vels University, Pallavaram, Chennai 600 117, Tamil Nadu, India
2,4 Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical sciences,
Vels University, Pallavaram, Chennai 600 117, Tamil Nadu, India
3 Director, School of Pharmaceutical sciences, Vels University, Pallavaram, Chennai 600 117, Tamil Nadu, India
5* Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical sciences, Vels University, Pallavaram, Chennai 600 117, Tamil Nadu, IndiaCorresponding author:
B.Senthilnathan
Assistant Professor,
Department of Pharmaceutics,
School of Pharmaceutical sciences,
Vels University, Pallavaram,
Chennai 600 117, Tamil Nadu, India
Received on: 12-04-2011; Revised on: 18-05-2011; Accepted on:21-06-2011-
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Author: Anusha Rupenagunta 1, I.Somasundaram 2, V.Ravichandiran3, J.Kausalya4, B.Senthilnathan 5*
Title: Solid lipid Nano particles-A versatile carrier system Journal: Journal of Pharmacy Research Vol(issue): 4 (July) Year: 2011 Page No: (2069-2075) -
Experimental Methods Keywords
Methodology: Solubility; Zeta potential; Hydrophobic; Colloidal carrier. Research Materials: Solid lipid nanoparticles
Keywords
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