Journal: JPR:BioMedRx:An International Journal
Title: Melatonin protects against lead-induced oxidative stress in stomach, duodenum and spleen of male Wistar rats
Category: Pharmacology
Section: Research Article
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Abstract
Environmental or occupational or even accidental exposure to certain heavy metals can cause generation of reactive oxygen species (ROS) which are major causes of various diseases. Our present investigation demonstrates that the oral supplementation of aqueous solution ofmelatonin has the potential to protect against the oxidative stress in stomach, duodenum and spleen induced by sub-chronic exposure of theexperimental rats to the heavy metal , lead (Pb). Rats were intraperitoneally injected with lead acetate (15mg/kg body weight). Another group was pre-treated with melatonin (10 mg / kg, fed orally).The positive control group was fed melatonin (10 mg / kg), and the control animals received vehicle treatment i.p. for 7 consecutive days. The alterations in the activity of the different biomarkers of oxidative stress and the activities of the antioxidant enzymes were studied. Histo-morphological changes in the gastric, duodenal and splenic tissues were studied through H-E staining. Lead caused alterations in all the parameters studied. All these changes were mitigated in all the three tissues when the
rats were pre-treated with melatonin. The results indicate that melatonin protects against lead-induced damages in stomach, duodenum and spleen in experimental rats by antioxidant mechanism. Melatonin may have future therapeutic relevance in the prevention of lead-induced gastro-toxicity as well as in splenic toxicity and duodenal toxicity in humans exposed occupationally or environmentally to this toxic heavy metal and may be used for development of new drug with almost no or minimum side-effect. -
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About the authors and Affiliations
Author(s) Name: Sanatan Mishra1,2 , Debosree Ghosh1, Mousumi Dutta1,2, Aindrila Chattopadhyay2, Debasish Bandyopadhyay1*#
Affiliation(s) Name: 1 Department of Physiology, University of Calcutta, University College of Science and Technology,92, APC Road, Kolkata 700 009 India.
#Principal Investigator, Centre with Potential for Excellence in a Particular Area (CPEPA),University of Calcutta, University College of Science and Technology, 92 APC Road, Kolkata 700 009 India.
2Department of Physiology, Vidyasagar College, 39, Shankar Ghosh Lane, Kolkata 700009, India.*Corresponding author.
Dr. Debasish Bandyopadhyay
Oxidative Stress and Free Radical Biology Laboratory,
Department of Physiology
University of Calcutta
University College of Science and Technology
92, APC Road, Kolkata 700 009 IndiaReceived on:17-08-2013; Revised on:16-09-2013; Accepted on:21-10-2013
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Author: Sanatan Mishra1,2 , Debosree Ghosh1, Mousumi Dutta1,2, Aindrila Chattopadhyay2, Debasish Bandyopadhyay1*#
Title: Melatonin protects against lead-induced oxidative stress in stomach, duodenum and spleen of male Wistar rats Journal: JPR:BioMedRx:An International Journal Vol(issue): 1 (November ) Year: 2013 Page No: (997-1004) -
Experimental Methods Keywords
Methodology: oxidative stress Research Materials: Melatonin
Keywords
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