Journal: Journal of Pharmacy Research
Title: Synthesis and Anti-Inflammatory Activity of Some 5-Phenyl-1-(Acyl)-1, 2, 3, 4-Tetrazole.
Category: Pharmaceutical Chemistry
Section: Research Article
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Abstract
A series of novel 5-phenyl,1-acyl 1,2,3,4-tetrazoles (3–10) have been synthesized via condensation of 5-phenyl-1,2,3,4-tetrazoles (2) with various acylating reagents. 5-phenyl- 1,2,3,4-tetrazoles was synthesized by the cycloaddition of Benzonitrile(1) with sodium azide and ammonium chloride in presence of Dimethylformamide as solvent. All synthesized compounds which were characterized to be new substituted Tetrazoles. Their structures were determined by 1H NMR,FT-IR, mass spectra and elemental analyses. The compounds synthesized were screened for anti-inflammatory activity. Compounds 4, 7 and 9 possess potent anti-inflammatory activity.
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About the authors and Affiliations
Author(s) Name: Popat B. Mohite*1, Ramdas B.Pandhare1, Shantaram G.Khanage, 1 Vaidhun H. Bhaskar2.
Affiliation(s) Name: 1MES College of Pharmacy, Sonai,Ahmednagar,Maharashtra,India
2MP Patel College of Pharmacy,Kapadwanj, Gujrat,India.*Corresponding author.
Mr.Popat B.Mohite
MES College of Pharmacy, Sonai
Tel-Newasa, Dist-Ahmednagar
Maharashtra-414105 India
Received on: 20-09-2009; Revised on: 09-10-2009; Accepted on:12-12-2009-
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How to Cite my Article.
Author: Popat B. Mohite*1, Ramdas B.Pandhare1, Shantaram G.Khanage, 1 Vaidhun H. Bhaskar2.
Title: Synthesis and Anti-Inflammatory Activity of Some 5-Phenyl-1-(Acyl)-1, 2, 3, 4-Tetrazole. Journal: Journal of Pharmacy Research Vol(issue): 3 (January) Year: 2010 Page No: (43-46) -
Experimental Methods Keywords
Methodology: Synthesis and Anti-Inflammatory Activity Research Materials: 5-Phenyl-1-(Acyl)-1, 2, 3, 4-Tetrazole
Keywords
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