Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001419
Title: Biodegradable nanoparticle: emerging research area for novel drug delivery
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    The advances in nanotechnology, helps in preparing nanoparticles which contain biologically active proteins that have total benefits of nanoparticulate system with maintain the stability and activity of the biological preparations against low pH of gastric fluid and action of proteolytic enzymes. The nanoparticle preparation method discussed is ionic relation between a polycationic and a polyanionic polymer under magnetic stirring. The polymer used for preparation of  nanoparticles are biodegradable and hydrophilic. Nanoparticles due to their small size can penetrate through smaller capillaries and are easy taken up by cells that allow efficient drug accumulation at the target sites. Whatever, the objective of the present study was to achieve drug loading into the matrices of gelatin-based nanoparticles through incubation of the drug-gelatin solution preceding to preparation and cross-linking of the nanopaticles in situ. This review gives the various traditional and novel techniques of preparing various drug loaded PLGA devices, with emphasis on preparing micro-particles. It also include a characterization of the nanoparticle with the study of particle size, particle morphology, FTIR, and a particle structure. It may also include a advantages and disadvantages of the various Biodegradable  Nanoparticles. Encapsulation of many drugs in to the nanopaticles like PLGA and others may also studied in it. They provide a various ideas regarding selection of polymer for different type of diseases.

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    Author(s) Name:

    Gavande Sunil D*1., Salunke Hemant D.1, Ughade Prajakta  L.1, Baviskar Dheeraj  T.1,  Jain Dinesh K.2

    Affiliation(s) Name:

    1Department of Pharmaceutics, Institute of Pharmaceutical Education, Boradi, Shirpur,425 428 (M.S.),India
    2 College of Pharmacy, I.P.S. Academy, Rajendra Nagar, Indore,452 012,(M.P.), India

    *Corresponding author.
    Sunil Dinkar Gavande,
    At.post-Avana,Tq.Bhokardan,
    Dist-Jalna
    Pin-431114, (Maharashtra)

    Received on:20-09-2011; Revised  on: 15-10-2011; Accepted on:10-12-2011

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    Author:

    Gavande Sunil D*1., Salunke Hemant D.1, Ughade Prajakta  L.1, Baviskar Dheeraj  T.1,  Jain Dinesh K.2

    Title:Biodegradable nanoparticle: emerging research area for novel drug delivery
    Journal:Journal of Pharmacy Research
    Vol(issue):5 (January)
    Year:2012
    Page No: (169-173)
  • Experimental Methods Keywords

    Methodology:Biodegradable, Drug, PLGA Device, Micro-particle.
    Research Materials:Biopolymer

Keywords

Nanotechnology Biodegradable Drug PLGA Device Micro-particle.

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