Journal: Journal of Pharmacy Research
Title: Simultaneous estimation of Sitagliptin and Metformin hydrochloride in bulk and dosage form by UV spectrophotometry
Category: Pharmaceutical Analysis
Section: Research Article
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Abstract
A simple, precise, rapid and economic method was developed for the simultaneous determination of Sitagliptin and Metformin HCl in bulk and dosage form. UV spectrophotometric method involves first order derivative spectroscopy using 238.5 nm & 216.0 nm as zero crossing points for Sitagliptin and Metformin HCl respectively. For spectrophotometric method, 0.1 N NaOH was used as a solvent. Linearity was observed in concentration range of 10-100 µg/ml of Sitagliptin and 2-20 µg/ml Metformin HCl. Results of analysis were validated statistically and by recovery studies.
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About the authors and Affiliations
Author(s) Name: Swati Kupkar, Shailaja Jadhav*, Vaibhavi Kunjir, Praveen Chaudhari
Affiliation(s) Name: Department of Pharmaceutical Chemistry,Modern College of Pharmacy, Nigdi,Pune - 411 044. Maharastra, India.
*Corresponding author.
Shailaja B. Jadhav
H.O.D.
Department of Pharmaceutical Chemistry
Modern College of Pharmacy, Nigdi,
Pune - 411 044. Maharastra, India
Received on:20-09-2011; Revised on: 15-10-2011; Accepted on:10-12-2011-
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Author: Swati Kupkar, Shailaja Jadhav*, Vaibhavi Kunjir, Praveen Chaudhari
Title: Simultaneous estimation of Sitagliptin and Metformin hydrochloride in bulk and dosage form by UV spectrophotometry Journal: Journal of Pharmacy Research Vol(issue): 5 (January) Year: 2012 Page No: (580-582) -
Experimental Methods Keywords
Methodology: First order derivative, UV spctrophotometry, Validation Research Materials: Sitagliptin, Metformin HCl
Keywords
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