Journal: Journal of Pharmacy Research

Article Id: JPRS-PA-00001443
Title: Simultaneous estimation of Sitagliptin and Metformin hydrochloride in bulk and dosage form by UV spectrophotometry
Category: Pharmaceutical Analysis
Section: Research Article
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  • Abstract

    A simple, precise, rapid and economic method was developed for the simultaneous determination of Sitagliptin and Metformin HCl  in bulk and dosage form. UV spectrophotometric method involves first order derivative spectroscopy using 238.5 nm & 216.0 nm as zero crossing points for Sitagliptin and Metformin HCl respectively. For spectrophotometric method, 0.1 N NaOH was used as a solvent. Linearity was observed in concentration range of  10-100 µg/ml of Sitagliptin and 2-20 µg/ml Metformin HCl. Results of analysis were validated statistically and by recovery studies.

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    Author(s) Name:

    Swati Kupkar, Shailaja Jadhav*, Vaibhavi Kunjir, Praveen Chaudhari

    Affiliation(s) Name:

    Department of Pharmaceutical Chemistry,Modern College of Pharmacy, Nigdi,Pune - 411 044. Maharastra, India.

    *Corresponding author.
    Shailaja B. Jadhav
    H.O.D.
    Department of Pharmaceutical Chemistry
    Modern College of Pharmacy, Nigdi,
    Pune - 411 044. Maharastra, India

    Received on:20-09-2011; Revised  on: 15-10-2011; Accepted on:10-12-2011

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    Author:

    Swati Kupkar, Shailaja Jadhav*, Vaibhavi Kunjir, Praveen Chaudhari

    Title:Simultaneous estimation of Sitagliptin and Metformin hydrochloride in bulk and dosage form by UV spectrophotometry
    Journal:Journal of Pharmacy Research
    Vol(issue):5 (January)
    Year:2012
    Page No: (580-582)
  • Experimental Methods Keywords

    Methodology:First order derivative, UV spctrophotometry, Validation
    Research Materials:Sitagliptin, Metformin HCl

Keywords

Sitagliptin Metformin HCl First order derivative UV spctrophotometry Validation

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