Journal: Journal of Pharmacy Research
Title: Simultaneous Estimation of Atenolol and Losartan Potassium By High Performance Liquid Chromatography and UV Spectrophotometric Method
Category: Pharmaceutics
Section: Research Article
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Abstract
A simple, rapid, precise and accurate isocratic reversed-phase HPLC method was developed and validated for the simultaneous determination of Atenolol (AT) and Losartan (LO) in commercial tablets. Chromatographic separation was achieved with ODS C-18 column (5ìm, 250 mm × 4.60 mm) using mobile phase consisting of acetonitrile : water : methanol (60:30:10) at a flow rate of 1 ml/min and UV detection at 235 nm. The retention time of Atenolol and losartan were observed at 2.18 min and 5 min respectively. The LOD for AT and LO were found to be 0.032 ìg/ml and 0.002 ìg/ml, respectively. In UV spectrophotometric method the lmax for Atenolol and Losartan was 275 nm and 232 nm respectively. The linearity of the proposed in UV spectrophotometric method was investigated in the range of 5-50 ìg/ml (r2 = 0.9942) for AT and (r2 = 0.995) for LO.
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About the authors and Affiliations
Author(s) Name: Dwivedi N. and Patil U. K.*
Affiliation(s) Name: People’s Institute of Pharmacy and Research Centre,People’s University, Bhanpur, Bhopal (M.P.) 462037 India
*Corresponding author.
Patil U. K
People’s Institute of Pharmacy and Research Centre,People’s University, Bhanpur,
Bhopal (M.P.) 462037 IndiaReceived on:10-11-2011; Revised on: 15-12-2011; Accepted on:12-01-2012
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Author: Dwivedi N. and Patil U. K.*
Title: Simultaneous Estimation of Atenolol and Losartan Potassium By High Performance Liquid Chromatography and UV Spectrophotometric Method Journal: Journal of Pharmacy Research Vol(issue): 5 (January) Year: 2012 Page No: (681-685) -
Experimental Methods Keywords
Methodology: Reverse Phase HPLC; Simultaneous estimation Research Materials: Atenolol; Losartan
Keywords
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