Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001458
Title: Formulation and evaluation of Isoniazid loaded -∑-polycaprolactone nanoparticles
Category: Pharmaceutics
Section: Research Article
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    The present study was aimed at developing a sustained release formulation of Isoniazid (INH) nanoparticles using the biodegradable polymers, poly-∑-caprolactone (PCL) as carrier. The PCL nanoparticles (NP) of hydrophilic dug isoniazid (INH), a first line antitubercular drug are developed and the entrapment efficiency of drug in the NPs has been improved. The PCL NPs were prepared by an oil-in-water emulsion solvent evaporation with ultrasonication technique. 32 factorial designs employed to optimized formula. Two independent variables like ultrasonication time and PCL Concentration were selected for factorial design for its significant effect on particle size, entrapment efficiency of NPs. The prepared PCL NPs were characterized by SEM analysis, entrapment efficiency, zeta potential, FTIR, DSC, in-vitro diffusion studies. These results indicate that INH loaded PCL nanoparticles could be effective in sustaining its release for a prolonged period. The PCL NPs could be alternate method for delivery for INH with prolonged drug release profiles and better therapeutic effect can be achieved for the treatment of tuberculosis. However, further studies are needed to confirm its performance in vivo.

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    Author(s) Name:

    Atanu Kumar Behera*1, Dr. B.B.Barik2, S.Pandya3, Snehal Joshi4

    Affiliation(s) Name:

    Department of pharmaceutical sciences, Utkal University Bhubaneswar1,
    College of Pharmacy, Jazan University, Kingdom of Saudi Arabia2,
     Pioneer Pharmacy Degree college-vadodara3
    Department of Pharmacology, Dadhichi College of pharmacy-Cuttack4.

    *Corresponding author.
    Atanu Kumar Behera
    Department of pharmaceutical sciences, Utkal University Bhubaneswar,
    Orisa, India
    Received on:10-11-2011; Revised  on: 15-12-2011; Accepted on:12-01-2012

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    Author:

    Atanu Kumar Behera*1, Dr. B.B.Barik2, S.Pandya3, Snehal Joshi4

    Title:Formulation and evaluation of Isoniazid loaded -∑-polycaprolactone nanoparticles
    Journal:Journal of Pharmacy Research
    Vol(issue):5 (February)
    Year:2012
    Page No: (798-802)
  • Experimental Methods Keywords

    Methodology:Formulation , evaluation
    Research Materials:Polycaprolactone

Keywords

Polycaprolactone Nanoparticles hydrophilic drugs isoniazid

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