Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001584
Title: Formulation of olmesartan medoxomil nanoparticulate drug delivery for enhancement of oral bioavailability by Ionic-Gelation Techniques
Category: Pharmaceutics
Section: Research Article
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  • Abstract

    The drug olmesartan medoxamil bioavailability is only 26% due to its poor aqueous solubility. The purpose of this study is to improve aqueous solubility by nanotechnology of Ionicgelation technique using chitosan as polymer and tripoly phosphate as cross linking agent. The nanoparticles of olmeasartan medoxamil is formulated to increase oral bioavailability by preparing particles of nano size range with good zeta potential and SEM analysis of prepared particle is done to confirm the surface morphology of nanoparticles with free of clusters. The different formulation of olmesartan medoxomil nanoparticles were compressed into tablets and it complies with IP standard for tablet. In-vitro release study of all the formulation were done to confirms its enhancement of in-vitro bioavailability, when compare to marketed formulation-M of 93 ± 2.95% drug release at 60 minutes, formulation OLM-9 of nanoparticle has shown 99% at 20 minutes with particle size of 633 nm, which indicates 3 fold increase in the in-vitro dissolution rate of olmesartan medoxomil. The prepared particles were free from clusters and with good zeta potential.

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  • About the authors and Affiliations

    Author(s) Name:

    Subramanian Somaskandan*1, Ravichandran Swaminathan2, Kavi Arasu Muthukuamraswamy1 , Mohammad Abdul Shareef1,

    Affiliation(s) Name:

       1 Department of  pharmaceutics, PSG College of  Pharmacy, Coimbatore - 641004 , Tamilnadu, India.
        2. Department of  pharmaceutical analysis, PSG College of  Pharmacy, Coimbatore - 641004 , Tamilnadu, India.
       

    *Corresponding author.
        Subramanian.S
        Associate Professor,
        Department of pharmaceutics,
        PSG College of Pharmacy,
        Coimbatore - 641004, Tamilnadu, India.
       

    Received on:21-06-2014; Revised  on: 19-07-2014; Accepted on:04-08-2014

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    Author:

    Subramanian Somaskandan*1, Ravichandran Swaminathan2, Kavi Arasu Muthukuamraswamy1 , Mohammad Abdul Shareef1,

    Title:Formulation of olmesartan medoxomil nanoparticulate drug delivery for enhancement of oral bioavailability by Ionic-Gelation Techniques
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (August)
    Year:2014
    Page No: (1067-1070)

  • Experimental Methods Keywords

    Methodology:Formulation,Evaluations, ionic gelation, SEM, bioavailability.
    Research Materials:Olmesartan medoxomil

Keywords

Olmesartan medoxomil ionic gelation SEM bioavailability.

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