Journal: Journal of Pharmacy Research
Title: Resveratrol in combination with Green Tea reduces myocardial infarct area and improves histological changes in isoproterenol-induced cardiotoxic rats
Category: Pharmacology
Section: Research Article
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Abstract
Background: Cardiovascular problem is a growing menace which is affecting people globally. Isoproterenol creates oxidative stress that leads to myocardial infarction. The extent of infarcted area in heart reflects the severity of toxicity. Histopathological changes induced by Isoproterenol become another tool for evaluating the effectiveness of the test drugs. In this study we therefore have considered these parameters to evaluate the effectiveness of our test drugs resveratrol, green tea and their combination. Methods: Thirty animals (n=5) were taken and randomly divided into Control, Isoproterenol (ISO), Resveratrol (RES) + ISO, Green Tea Extract (GTE) + ISO, RES + GTE+ ISO and RES + GTE groups. Rats were treated with the test drugs for thirty days and with ISO on 29th and 30th day. Animals were sacrificed on 31st day and histopathological studies and infarct size calculations were performed. Results and Discussions: Myofibril disintegration, vacuolation and pyknotic nucleus were observed in ISO treated rats which were considerably reversed by resveratrol, green tea extract and by their combination. The size of infarcted area in the heart of ISO treated rats was also significantly reduced when the rats were treated with these test drugs. Conclusion: Resveratrol and green tea extract both showed cardio protection in terms of restoration of histological changes and reduction of infarcted area but their combination was found to be better than them.
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About the authors and Affiliations
Author(s) Name: Ravi Kumar Gupta and Syed Ehtaishamul Haque*
Affiliation(s) Name: Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062,India
*Corresponding author.
Dr.Syed Ehtaishamul Haque
Department of Pharmacology
Faculty of Pharmacy, Jamia Hamdard,
New Delhi-110062, India
Received on:23-07-2016; Revised on: 14-08-2016; Accepted on: 07-09-2016-
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Author: Ravi Kumar Gupta and Syed Ehtaishamul Haque*
Title: Resveratrol in combination with Green Tea reduces myocardial infarct area and improves histological changes in isoproterenol-induced cardiotoxic rats Journal: Journal of Pharmacy Research Vol(issue): 10 (October) Year: 2016 Page No: (618-622) -
Experimental Methods Keywords
Methodology: Myocardial infarction, histopathology, infarct size Research Materials: Isoproterenol, green tea
Keywords
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