Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001623
Title: Effect of a model lipophilic compound on the phase behaviour of hydrophilic self-micro-emulsifying lipid formulations
Category: Pharmacology
Section: Research Article
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    Background:There has been growing interest in the self-emulsifying lipid technology in recent years as an approach to improve the oral bioavailability of poorly water-soluble compounds. Nonetheless, for the design of successful lipid formulations with a potential to maximize the bioavailability of lipophilic drugs, key elements in the lipid composite in relation to the physicochemical state of drug after dispersion needs to be optimized. Methods:In this study, various lipid formulations were optimized for oil-in-water micro-emulsion drug delivery systems. The effect of Ibuprofen (a model lipophilic drug) on the emulsification behavior of these systems was also investigated by constructing ternary phase equilibrium diagrams using dynamic phase behavior study method. Results and Discussion: Optimum self-micro-emulsifying systems were obtained by using oil blends of {Miglyol 812/Imwitor 308} at ratio of 5:5 in the case of Cremophor RH40 and 4:6 for Tagat S2 or Tagat S Ternary phase equilibrium diagrams reveal extended regions of L2 phase when no drug was added to the lipid mixtures. However, in the case of lipid formulations containing Ibuprofen at 100mg/g, small limited areas of L2 phase was observed which suggests that the drug can interfere in the mechanistic processes of emulsification. Conclusion: in order to design successful self-micro-emulsifying lipid systems, pre-formulation studies which affect the performance of resultant dispersions of these systems with and without drug should be carried using suitable emulsification media.

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    Author(s) Name:

    NaserM.Y. Hasan*1, 2

    Affiliation(s) Name:

    1 School of Pharmacy, Taif University, SaudiArabia
    2 Department of Pharmacy and Pharmacology, TheUniversity of Bath, UK

    *Corresponding author.
    Dr. Naser M.Y. Hasan
    School of Pharmacy,
    Taif University,

    Received on:19-08-2016; Revised  on:  16-09-2016; Accepted on: 05-10-2016   

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    NaserM.Y. Hasan*1, 2

    Title:Effect of a model lipophilic compound on the phase behaviour of hydrophilic self-micro-emulsifying lipid formulations
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (October)
    Page No: (647-654)
  • Experimental Methods Keywords

    Methodology:SMEDDS; SEDDS; Phase behavior studies; Poorly water-soluble drugs;
    Research Materials:lipophilic compound


SMEDDS; SEDDS; Phase behavior studies; Poorly water-soluble drugs; Cremophor RH40

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