Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001626
Title: Synthesis, characterization and antioxidant evaluation of 2-(2-substituted) naphthalene-1,4-dione derivatives
Category: Pharmaceutical Chemistry
Section: Research Article
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  • Abstract

    Background: 1,4- naphthoquinone (Lawsone) are widely distributed in nature and have been used since ancient times in traditional medicine. Lawsone has been used as a dye, and both its natural form and synthetic derivatives exhibit antifungal, antibacterial, antitumor, antimalarial, molluscicidal and antioxidant activity. Methods: 1,4- naphthoquinone (Lawsone) was isolated from the leaves of lawsonia inermis by using pH gradient method. A convenient synthesis of 2-substituted amino naphthalene-1,4-dione (3a-e) has been achieved by reaction of  isolated 1,4- naphthoquinone with substituted aniline in the presence of ethanol and evaluated for in- vitro antioxidant activity using DPPH model. The structure of the final analogues has been confirmed on the basis of elemental analysis, FTIR, 1H NMR and mass spectra. All the values of elemental analysis, FTIR, 1H NMR and mass spectra were found to be prominent. Results and discussion: The results indicate that synthesized compound 3d having IC50 75.39 ± 4.12 mg/ml showed potent antioxidant activity comparable to standard ascorbic acid (IC50 45.54 ± 3.06 mg/ml). Conclusion: This study suggests that leaves of Lawsonia inermis have bioactive compounds for a new antioxidant drug development.

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    Author(s) Name:

    Bhumika Yogi*1 and Ashutosh Mishra2

    Affiliation(s) Name:

    *1Department of Pharmaceutical Chemistry, Hygia Institute of Pharmaceutical Education and Research, Lucknow-206020,Uttar Pradesh, India.
    2Department of Pharmaceutical Chemistry, Acharya Narendra Deo College of Pharmacy, Babhnan, Gonda – 271313, Uttar Pradesh,India.

    *Corresponding author.
    Bhumika Yogi
    Department of Pharmaceutical Chemistry, Hygia Institute of Pharmaceutical
    Education and Research,
    Lucknow-206020,
    Uttar Pradesh,India.

    Received on:28-08-2016; Revised on: 18-09-2016; Accepted on: 13-10-2016

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    Author:

    Bhumika Yogi*1 and Ashutosh Mishra2
    Title:Synthesis, characterization and antioxidant evaluation of 2-(2-substituted) naphthalene-1,4-dione derivatives
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (October)
    Year:2016
    Page No: (655-659)

  • Experimental Methods Keywords

    Methodology:Synthesis, characterization, In-vitro antioxidant activity
    Research Materials:Lawsonia inermis

Keywords

Lawsonia inermis Naphthoquinone In-vitro antioxidant activity leaves extract DPPH

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