Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001671
Title: Role of Cactus grandiflorus in reversal of histological disruption and extent of infarction on isoproterenol-induced myocardial damage in wistar rats
Category: Pharmacology
Section: Research Article
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    Background: Isoproterenol (ISO) is a known drug that is used experimentally to induce myocardial infarction (MI) in rats. Beside various disturbances, histopathological disturbances are a prominent marker of myocardial toxicity. Several molecules are continuously being explored for their efficacy in reversing these changes. Cactus grandiflorus is frequently used in homeopath as a cardioprotective drug but its scientific validation is still not established. This study is therefore a move in this direction. Methods:Wistar rats were randomly divided into (1) Normal (normal saline) (2) Toxic (ISO, 85 mg/kg, s.c). (3) C. grandiflorus (0.5 ml/kg, p.o.) and ISO (85 mg/kg, s.c). (4) C. grandiflorus (1.0 ml/kg, p.o.) and ISO (85 mg/kg, s.c). (5) Vitamin-E (100 mg/kg, p.o.) and (6) C. grandiflorus per se (1.0 ml/kg, p.o.). Study was done for a period of 15 days.  C. grandiflorus was administered twice daily and ISO on 14th and 15th day. After 15 days treatment rats were sacrificed and hearts were isolated. Infarct size measurement and histopathological evaluation of the heart tissues were then performed. Results and discussion: Pre-treatment with C. grandiflorus (0.5 ml/kg and 1.0 ml/kg) showed reversal of cellular damage and myocardial infarction on dose-dependent manner. This could be due to antioxidant effect of C. grandiflorus that normalized the oxidative stress created by isoproterenol.

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    Author(s) Name:

    Sayima Nabi, Vasim Khan, Sumit Sharma, Rustam Ekbbal, Mohd. Asif Ansari and Syed Ehtaishamul Haque*

    Affiliation(s) Name:

    Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi–110062, India

    *Corresponding author.
    Dr. Syed Ehtaishamul Haque,
    Department of Pharmacol ogy,
    Faculty of Pharmacy, Jamia Hamdard
    New Delhi – 110062, India

    Received on:24-12-2016; Revised on: 12-01-2017; Accepted on: 17-02-2017

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    Author:

    Sayima Nabi, Vasim Khan, Sumit Sharma, Rustam Ekbbal, Mohd. Asif Ansari and Syed Ehtaishamul Haque*

    Title:Role of Cactus grandiflorus in reversal of histological disruption and extent of infarction on isoproterenol-induced myocardial damage in wistar rats
    Journal:Journal of Pharmacy Research
    Vol(issue):11 (February)
    Year:2017
    Page No: (142-145)
  • Experimental Methods Keywords

    Methodology:histopathological evaluation, Antioxidant activity
    Research Materials:Cactus grandiflorus

Keywords

Antioxidant Cactus grandiflorus Isoproterenol Vitamin-E Homeopathic Medicine

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