Journal: Journal of Pharmacy Research
Title: Oral dissolving films of Celecoxib inclusion complexes using Musa paradisiaca as super disintegrant in treatment of Psoriatic arthritis
Category: Pharmaceutics
Section: Research Article
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Abstract
Celecoxib is a poorly water soluble drug which is a selective COX-2 inhibitor used in treating Psoriatic arthritis. It shows poor dissolution and flow properties. So physical mixures of the drug using solubilizers like β CD were prepared in order to enhance its solubility and dissolution rate. Super disintegrant plays a vital role in increasing drug release. Musa paradisiaca, a natural excepient is used in this study as a super disintegrant. The aim of present study was to formulate oral dissolving films of Celecoxib using solubilizer and evaluate them for in vitro disintegration and dissolution rates. It was found that β CD had shown good impact on increasing solubility and dissolution rate. Drug excepient compatibility was studied by FTIR studies.
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About the authors and Affiliations
Author(s) Name: Padmini Iriventi*, N. Vishal Gupta
Affiliation(s) Name: Department of Pharmaceutics, JSS College of Pharmacy, Jagadguru Sri Shivarathreeshwara University, Sri Shivarathrishwara Nagara, Mysuru-570015, India.
*Corresponding author
Padmini Iriventi
Department of Pharmaceutics,
JSS College of Pharmacy,
Shivarathrishwara Nagara,
Bannimantap,Mysuru 570015, IndiaReceived on:18-03-2017; Revised on: 22-04-2017; Accepted on: 24-05-2017
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Author: Padmini Iriventi*, N. Vishal Gupta
Title: Oral dissolving films of Celecoxib inclusion complexes using Musa paradisiaca as super disintegrant in treatment of Psoriatic arthritis Journal: Journal of Pharmacy Research Vol(issue): 11 (May) Year: 2017 Page No: (517-521) -
Experimental Methods Keywords
Methodology: Oral dissolving films ,solubility, dissolution rate studies Research Materials: Musa paradisiaca, Celecoxib
Keywords
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